Introduction
Toxoplasma gondii, a parasite that, through millennia of evolution, has the ability to infect most mammals, including humans. It is often transmitted through feces from felines, but the parasite is also found in the tissue of infected production animals. Therefore, it is considered a food-borne infection and affects many millions of people every year. The WHO estimates that nearly six billion people in the world have been exposed to the infection.
Aim of the study
The aim of the study is to highlight current research on latent toxoplasmosis with the intention of increasing knowledge about the disease in healthcare and in society as it is a growing global health problem according to WHO and One Health initiative.
Method
Structured literature review according to State-of-the-Art methodology.
Results
Both animal and human studies show that there is a strong link between latent toxoplasmosis and neurological and psychiatric symptoms, but more longitudinal studies on latent toxoplasmosis are needed to describe the long-term impairment of health and symptoms the disease may cause.
The parasite can cause a short and often asymptomatic acute stage but may also cause a lifelong latent phase. Infection with Toxoplasma gondii can cause cysts in tissues, internal organs and in the nervous system. It also has the ability to cause spontaneous abortions and congenital lesions in fetuses and young individuals in both animals and humans.
In the nervous system, it can cause tissue cysts in the brain and cell-mediated immune response may cause inflammation in the brain which, together with cysts in the brain, can cause severe neurological symptoms and psychiatric diseases as well as behavioral changes in the person affected.
Conclusion
Toxoplasma gondii has the ability to manipulate the brain, modulate the pathway of neurotransmitters and alter the levels of neurotransmitters in the brain and create inflammation in the brain of the sufferer. These changes can lead to serious behavioural changes such as increased risk-taking, increased impulsivity, increased aggressiveness, increased risk of suicide, but can also contribute to the development of schizophrenia and other psychotic disorders as well as increased depression, anxiety and obsessive-compulsive disorder. Toxoplasmosis may well be a possible risk factor for mental illness, perhaps even a possible explanation for an increasing propensity for violence in society.