Disorders of consciousness (DOC) present major challenges in rehabilitation and recovery. Music-based interventions have been proposed as a promising method to stimulate brain activity and promote awareness. This systematic review aimed to evaluate whether music-based interventions influence neural activity, autonomic regulation or behavioural indicators of consciousness in adult patients with DOC. Six studies were included, collected from the databases: Medline Ebsco, Web of Science and Scopus. The studies cover various types of music-based interventions such as live music therapy, passive listening, and therapist-selected or preferred music. The studies used outcome measures including electroencephalography, functional magnetic resonance imaging, heart rate variability and behavioural scales. The results from the studies suggest that music-based interventions may enhance brain activity, support autonomic balance and elicit signs of awareness. However, variability in sample sizes, methods, and outcome measures limits the generalizability of these results. Overall, the reviewed studies indicate that music could serve as a valuable complementary intervention in DOC rehabilitation. Future research should aim to standardize protocols and assess long-term clinical impact.