Carnivore diet is a high-protein ketogenic diet in which only animal-derived food is consumed. Unhealthy dietary patterns and obesity are linked with systemic chronic inflammation, which can increase disease burden and decrease longevity. Despite the limited research, the carnivore diet has the potential to decrease systemic chronic inflammation through a reduction in weight, ketone body signaling, alterations in gut microbiota, and avoidance of ultra-processed food. The current study aimed to evaluate the changes in anthropometric measurements and various clinical and serum marker measurements, with a focus on inflammation. The study consisted of four healthy young adults, all of whom consumed a high-carbohydrate diet, and underwent a three-week dietary intervention of ad libitum unprocessed beef, unprocessed chicken, and egg consumption. After the dietary intervention, participants experienced significant weight loss (-4 kg; p=0.032). The relative expression of tumor necrosis factor (TNF) was significantly lower (p=0.006) after the diet, with non-significant changes (p>0.05) in all other inflammatory markers, including high-sensitivity C-reactive protein (hs-CRP), homocysteine, interleukin 6 (IL6), interleukin 10 (IL10), C-X-C motif chemokine ligand 1 (CXCL1), and white blood cell count (WBCC). Systolic (p=0.039) and diastolic (p=0.005) blood pressure were significantly reduced. Branched-chain amino acids were all elevated, with isoleucine (p=0.031) being significant. Sarcosine was also significantly elevated (p=0.013). The study provides preliminary findings that inflammatory markers remain relatively unchanged or lower in healthy participants after the carnivore diet, but might be more significant with a higher sample size and in individuals with obesity and inflammatory diseases.