The investigation into the therapeutic potential of psychedelics has marked a paradigm shift in mental health research, with potential outcomes for disorders such as depression. Amidst the diverse varieties of psychedelic effects, one phenomenon that has captured the researcher’s attention is the term ego dissolution: a state characterized by the dissolution and reduction of one’s ego. Yet, within this phenomenon, a gap exists, one that links the dissolution of an individual’s ego to the potential treatment of depression. The study aims to understand the connection between ego dissolution and depression. Neural processes will be discussed to provide further insight into the relationship between brain activity and subjective experiences during ego dissolution. The present study reveals a negative correlation between ego dissolution and depression, indicating decreased depression levels. The collective findings highlight ego dissolution as a possible component in psychedelic therapy, associated with improved mental health outcomes.