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Genome-wide association study of type 2 diabetes-related traits on Iraqis and native Swedes
University of Skövde, School of Bioscience.
2021 (English)Independent thesis Advanced level (degree of Master (Two Years)), 30 credits / 45 HE creditsStudent thesis
Abstract [en]

Type 2 diabetes (T2D) is a significant public health problem affecting more than 6.28% of the world population. T2D is the leading cause of kidney failure and high blood pressure. Malmo residence born in Iraqi are known to have high T2D prevalence, poor glycemic control, and more metabolic risk factor. However, they have better kidney function and lower blood pressure compared to native Swedes. This study aimed to understand the underlying genetic basis of this difference by performing GWAS of T2D related traits on people of Iraqi ancestry and swedes in Malmo. A total of 2075 residents of Malmo born in Iraq (N= 1,344) and Sweden (N= 731) were genotyped, imputed using HRC reference panel and tested for association with 11 T2D-related traits using a linear mixed model. Out of the eleven phenotypes tested for association in the Iraqi group, novel loci for fasting glucose (in CAMTA1, NDUFA10, TRIO, WWC1, TRAPPC9, SH3GL2 and ABCC11), Quicki (in METTL16), eGFR (in ERBB4 and CST9), and HbA1C (in CAMTA1, ME1, PAK1 and RORA) was identified at a genome-wide significant level; eGFR had the highest number of hits. It showed 107 significant SNPs within Chromosome 20 with an effect size greater than 0.06. A further 83 lead variants reached a borderline to the genome-wide significance, and out of these borderline to significant variants, 37 SNPs show a lowering effect on blood pressure. In the Swedes group, only Quicki showed a significant association at the loci CTNND2. This study, inaddition to identifying novel variant, it also demonstrated the underlying reason behind the improved kidney function and better blood pressure profile of the Middle Eastern population.

Place, publisher, year, edition, pages
2021. , p. 32
National Category
Bioinformatics and Computational Biology
Identifiers
URN: urn:nbn:se:his:diva-19595OAI: oai:DiVA.org:his-19595DiVA, id: diva2:1542188
External cooperation
Lund University
Subject / course
Systems Biology
Educational program
Infection Biology - Master’s Programme 120 ECTS
Supervisors
Examiners
Available from: 2021-04-07 Created: 2021-04-07 Last updated: 2025-09-29Bibliographically approved

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CiteExportLink to record
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Cite
Citation style
  • apa
  • apa-cv
  • ieee
  • modern-language-association-8th-edition
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More styles
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  • de-DE
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