Managing fever in febrile patients is vital for effective management, and this study sought to evaluate the emerging antipyretic options for the management of fever. A literature review was performed via electronic search in PubMed and Google Scholar, ultimately identifying 12 studies that met the inclusion criteria, comprising 7,865 patients from multiple regions. The studies included in this meta-analysis, each had the following characteristics: prospective cohort methodology, the effect size being odds ratios (OR), and a comparison of emerging antipyretic treatments and standard treatments. The pooled OR analysis with a random-effects model found that the new antipyretic manages fever better than traditional methods (pooled OR: 1.50; 95% CI: 1.30-1.75; p < 0.001). Subgroup analyses showed that there was a 1.8-times greater change in duration of fever (OR: 1.8; 95% CI: 1.42-2.15) and a 1.5-times greater change in patient comfort level (OR: 1.5; 95% CI: 1.30-1.70). These findings would suggest that new antipyretic therapies ought to be considered as part of a fever management protocol. Clinicians ought to consider these options for enhanced management of fever, particularly in critically ill patients. Future studies should provide data on longer-term safety and effectiveness, especially for vulnerable populations.