Högskolan i Skövde

his.sePublications
CiteExportLink to record
Permanent link

Direct link
Cite
Citation style
  • apa
  • apa-cv
  • ieee
  • modern-language-association-8th-edition
  • vancouver
  • Other style
More styles
Language
  • de-DE
  • en-GB
  • en-US
  • fi-FI
  • nn-NO
  • nn-NB
  • sv-SE
  • Other locale
More languages
Output format
  • html
  • text
  • asciidoc
  • rtf
Developing a multivariable prediction model of global health-related quality of life in patients treated for rectal cancer: a prospective study in five countries
Department of General and Orthopaedic Surgery, Alingsås Hospital, Sweden ; Department of Surgery, SSORG - Scandinavian Surgical Outcomes Research Group, Institute of Clinical Sciences, Sahlgrenska Academy, University of Gothenburg, Sweden.
Department of Surgery, SSORG - Scandinavian Surgical Outcomes Research Group, Institute of Clinical Sciences, Sahlgrenska Academy, University of Gothenburg, Sweden ; Department of Surgery, Region Västra Götaland, Sahlgrenska University Hospital/Östra, Gothenburg, Sweden.
University of Skövde, School of Health Sciences. University of Skövde, Digital Health Research (DHEAR). (Research on Citizen Centered Health, University of Skövde (Reacch US))ORCID iD: 0000-0002-0575-4309
Department of Surgery, SSORG - Scandinavian Surgical Outcomes Research Group, Institute of Clinical Sciences, Sahlgrenska Academy, University of Gothenburg, Sweden ; Department of Surgery, Region Västra Götaland, Sahlgrenska University Hospital/Östra, Gothenburg, Sweden.
2024 (English)In: International Journal of Colorectal Disease, ISSN 0179-1958, E-ISSN 1432-1262, Vol. 39, article id 35Article in journal (Refereed) Published
Abstract [en]

Purpose Rectal cancer and its treatment have a negative impact on health-related quality of life (HRQoL). If risk factors for sustained low HRQoL could be identified early, ideally before the start of treatment, individualised interventions could be identified and implemented to maintain or improve HRQoL. The study aimed to develop a multivariable prediction model for global HRQoL 12 months after rectal cancer treatment.

Methods Within COLOR II, a randomised, multicentre, international trial of laparoscopic and open surgery for rectal cancer, a sub-study on HRQoL included 385 patients in 12 hospitals and five countries. The HRQoL study was optional for hospitals in the COLOR II trial. EORTC QLQ-C30 and EORTC QLQ-CR38 were analysed preoperatively and at 1 and 12 months postoperatively. In exploratory analyses, correlations between age, sex, fatigue, pain, ASA classification, complications, and symptoms after surgery to HRQoL were studied. Bivariate initial analyses were followed by multivariate regression models.

Results Patient characteristics and clinical factors explained 4–10% of the variation in global HRQoL. The patient-reported outcomes from EORTC QLQ-C30 explained 55–65% of the variation in global HRQoL. The predominant predictors were fatigue and pain, which significantly impacted global HRQoL at all time points measured.

Conclusion We found that fatigue and pain were two significant factors associated with posttreatment global HRQoL in patients treated for rectal cancer T1-T3 Nx. Interventions to reduce fatigue and pain could enhance global HRQoL after rectal cancer treatment.

Place, publisher, year, edition, pages
Springer Nature, 2024. Vol. 39, article id 35
Keywords [en]
Colorectal cancer, Quality of life, Risk factors, EORTC QLQ, Fatigue, Pain
National Category
Surgery Urology and Nephrology Cancer and Oncology
Research subject
Research on Citizen Centered Health, University of Skövde (Reacch US)
Identifiers
URN: urn:nbn:se:his:diva-23646DOI: 10.1007/s00384-024-04605-yISI: 001175078400001PubMedID: 38441657Scopus ID: 2-s2.0-85186581865OAI: oai:DiVA.org:his-23646DiVA, id: diva2:1842445
Funder
Swedish Cancer Society, CAN 2010/593CAN 2013/497Swedish Cancer Society, CAN 2016/362Swedish Cancer Society, Pj19 0303Anna-Lisa and Bror Björnsson FoundationStiftelsen Assar Gabrielssons fond
Note

CC BY 4.0 DEED

Eva Haglind eva.haglind@vgregion.se

This trial is registered with ClinicalTrials.gov No. NCT00297791

Open access funding provided by University of Gothenburg. The study received financial support from the Swedish state under the agreement between the Swedish government and the county councils, the ALF-agreement (ALFGBG-138751; ALFGBG-4307771; ALFGBG-718221; ALFGBG-965245), the Swedish Cancer Society (CAN 2010/593CAN 2013/497; CAN 2016/362; Pj19 0303), the Alice Swenson Foundation, Anna-Lisa and Bror Björnsson Foundation, Axel Linders Foundation, Assar Gabrielsson Foundation, and the Gothenburg Medical Society.

Available from: 2024-03-05 Created: 2024-03-05 Last updated: 2024-04-15Bibliographically approved

Open Access in DiVA

fulltext(757 kB)37 downloads
File information
File name FULLTEXT01.pdfFile size 757 kBChecksum SHA-512
ac490903d19a7cfec309bb04936bcc9004da1cb93b8dddb8604bac16b582e420c1d2fada790ce2e8b0380eace3fe023ed928cc9d1b2c6e78028b86879560c815
Type fulltextMimetype application/pdf

Other links

Publisher's full textPubMedScopus

Authority records

Gellerstedt, Martin

Search in DiVA

By author/editor
Gellerstedt, Martin
By organisation
School of Health SciencesDigital Health Research (DHEAR)
In the same journal
International Journal of Colorectal Disease
SurgeryUrology and NephrologyCancer and Oncology

Search outside of DiVA

GoogleGoogle Scholar
Total: 37 downloads
The number of downloads is the sum of all downloads of full texts. It may include eg previous versions that are now no longer available

doi
pubmed
urn-nbn

Altmetric score

doi
pubmed
urn-nbn
Total: 79 hits
CiteExportLink to record
Permanent link

Direct link
Cite
Citation style
  • apa
  • apa-cv
  • ieee
  • modern-language-association-8th-edition
  • vancouver
  • Other style
More styles
Language
  • de-DE
  • en-GB
  • en-US
  • fi-FI
  • nn-NO
  • nn-NB
  • sv-SE
  • Other locale
More languages
Output format
  • html
  • text
  • asciidoc
  • rtf