Cardiovascular diseases (CVD) are a broad range of serious conditions and are the result of multiple contributing factors. Modifiable causes such as lifestyle, nutrition, obesity and non-modifiable causes such as genetic factors, age and gender to name a few. The coronary artery disease atherosclerosis starts with an inflammatory forming lesion/plaque and eventually ends up with myocardial ischemia. Studies and research have suggested a range of biomarkers linked to CVD. Low-density lipids, high-density lipids, serum cholesterol, triglycerides and cytokines and chemokines such as: interleukins IL-6, -8 & IL-1β. Furthermore the oxidized lipids (LOX) enzymes 5-,12-,15-HETE have observed influence on the risk of CVD. This report aims to investigate the possible inflammatory molecules linked to contributing and predictive factors in ischemic CVD by different statistical methods using a prospective dataset X study. The results indicate level differences in terms of gender: Females have higher levels of IL-8 and 5-HETE, and they correlate positively. Plaque afflicted subjects have elevated IL-6 and IL-8 levels. Males are overrepresented in stated plaque and risk of future CVD. From these results, it can be concluded that inflammatory molecules have link to plaque and the prevalence of CVD in patients. Furthermore, CVD can still be considered a male condition.