Högskolan i Skövde

Introduction: Obesity and mental health disorders, such as depression and anxiety, are significant global health concerns (1). Dietary interventions may improve physical and mental health, likely via gut microbiome changes. This study assesses the feasibility of the MIND diet and its effects on weight loss, mental well-being, and gut microbiome composition in adults with obesity.

Method: This 12-week pilot randomized controlled trial includes two arms: an intervention group following the MIND diet and a control group assigned recommendations for a balanced diet. The study will recruit 126 adults with obesity in Sweden. Data collection includes body measurements, mental health questionnaires, and stool sample analyses using 16S rRNA gene sequencing. Primary endpoints are retention and adherence rates, while secondary outcomes include changes in mental well-being, gut microbiome diversity, and body composition.

Results: The primary expected findings include retention and adherence rates, which will determine the feasibility of a larger study. The study will also explore potential associations between dietary intake, weight loss, changes in mental health status, and shifts in gut microbiome composition. 

Conclusion: The MIND-GUT study seeks to explore the interconnections between diet, obesity, mental health, and the gut microbiome. 

References:

1. Segal Y, Gunturu S. Psychological Issues Associated With Obesity. In: StatPearls. Treasure Island (FL): StatPearls Publishing; 2025.

2. Liu X, Morris MC, Dhana K, et al. Mediterranean-DASH Intervention for Neurodegenerative Delay (MIND) study: Rationale, design and baseline characteristics of a randomized control trial of the MIND diet on cognitive decline. Contemp Clin Trials. 2021 Mar;102:106270.

Background: Obesity and mental health disorders often co-occur, contributingto individual suffering and healthcare costs. Diet plays a key role in both weight management and mental wellbeing and may influence these through its impact on the gut microbiota. However, the mechanisms linking diet, obesity, and mental health remain insufficiently understood.

Aim: We propose to conduct the MIND-GUT study in Sweden to evaluate feasibility as primary outcome (retention, adherence, and acceptability) of a 12-week dietary intervention based on the MIND diet and, as secondary outcomes, the influence of the latter on weight loss and mental wellbeing in adults with overweight and obesity [body mass index (BMI) ≥30 kg/m²]. The study will also explore changes in gut microbiota composition and diversity.

Methods: In this randomized trial, 126 adults with obesity will be assigned to either an intervention group following a MIND diet or a control group receiving general dietary advice. Energy intake targets will be <2,300 kcal/dayfor men and <1,900 kcal/day for women. The primary outcomes are retention, adherence, and intervention acceptability (the latter assessed through qualitative interviews). Secondary outcomes include changes in body weight, BMI, waistand hip circumferences, fat mass, and mental health including perceived stress,depression, and anxiety symptoms. Gut microbiota diversity and composition will be analyzed from stool samples collected at baseline and 12-week follow-up.

Discussion: This study will offer valuable insights into the relationship between diet, mental health, obesity, and the gut microbiota. Results will inform the design of future large-scale trials assessing the MIND diet’s potential as a strategy for improving physical and mental health.

Background and Objectives: To examine whether changes in the Mediterranean Diet (MD) or any of its MD food groups modulate the genetic susceptibility to obesity in European youth, both in cross-sectional and longitudinal analyses. Methods: For cross-sectional analysis, 1982 participants at baseline, 1649 in follow-up 1 (FU1) and 1907 in follow-up 2 (FU2), aged 2–16 years of the IDEFICS/I.Family studies were considered. For the longitudinal design, 1254 participants were included. Adherence to MD was assessed using the Mediterranean Diet Score (MDS), and genetic susceptibility to high BMI was assessed with a polygenic risk score (BMI-PRS). Multiple linear regression models were fitted to estimate gene × MD effects on markers of obesity. Results: In cross-sectional analyses, at baseline, higher MDS was associated with higher BMI in children with high genetic susceptibility (β = 0.12; 95% CI = [0.01, 0.24]). However, 6 years later, at FU2, higher MDS was associated with lower BMI (β = −0.19; 95% CI = [−0.38, −0.01]) in children with high genetic susceptibility, showing an attenuating MDS effect. Also in FU2, vegetables and legumes (V&L) showed inverse associations with BMI (β = −0.01; CI = [−0.02, −0.00]) and WC (β = −0.02; CI = [−0.03, −0.00]) regardless of the obesity genetic risk, although the effect sizes were small. In the longitudinal analyses, no MDS-obesity associations or gene × diet interaction effects were observed. Conclusions: In cross-sectional analysis (baseline and FU2), the MD modulated the association between obesity susceptibility and adiposity indicators in European youth, having an exacerbating effect in children measured during infancy years and an attenuating effect in early adolescent years.

As home working becomes more common, employers may struggle to provide health promotion interventions that can successfully bridge the gap between employees' intentions to engage in healthier behaviors and actual action. Based on past evidence that action planning can successfully encourage the adoption of healthier behaviors, this mixed-methods study of a web-based self-help intervention incorporated a randomized planning trial that included quantitative measures of engagement and follow-up qualitative interviews with a subsample of participants. Participants either (a) selected a movement plan for incorporating a series of 2-min exercise videos into their work week to break up sedentary time and a balanced meal plan with recipe cards for a week's lunches and dinners or (b) received access to these resources without a plan. Selecting a movement plan was more effective at increasing engagement with the web resources compared to the no-plan condition. In the follow-up interviews, participants indicated that the plan helped to remind participants to engage with the resources and made it simpler for them to follow the guidance for exercises and meals. Ease of use and being able to fit exercises and meals around work tasks were key factors that facilitated uptake of the resources, while lack of time and worries about how colleagues would perceive them taking breaks to use the resources were barriers to uptake. Participants' self-efficacy was associated with general resource use but not plan adherence. Overall, including plans with online self-help resources could enhance their uptake. 

Aflatoxins are toxic secondary metabolites produced mainly by Aspergillus flavus and A. parasiticus, which are fungal contaminants found in several foodstuffs, including spices. In this study 40 cinnamon samples were collected in November and December 2020 in the Iranian province of Yazd and analysed for the presence of aflatoxin B₁ (AFB₁) by high performance liquid chromatography. Seven out of 40 (17.5%) samples were contaminated with AFB₁ at levels ranging from 0.59 to 5.8 μg/kg. In addition, 2.5% of cinnamon samples contained AFB₁ concentrations above the maximum level of 5 μg/kg, as established by the Iranian national standard. Due to the harmful effects of aflatoxins, even at low amounts, these can cause serious chronic health problems. Therefore, continuous control to avoid AFB₁ contamination in foodstuffs is required.

In 2008, the Choices International Foundation developed its logo criteria, identifying best-in-class food products. More advanced, global and graded nutrient profiling systems (NPSs) are needed to substantiate different national nutrition policies. The objective of this work was to extend Choices NPS to identify five levels of the healthiness of food products, so that the Choices NPS can also be used to support other nutrition policies, next to front-of-pack labelling. Based on the same principles as the previous logo criteria, four sets of threshold criteria were determined using a com-bination of compliance levels, calculated from a large international food group-specific database, the Choices logo criteria, and WHO-NPSs developed to restrict marketing to children. Validation consisted of a comparison with indicator foods from food-based dietary guidelines from various countries. Some thresholds were adjusted after the validation, e.g., because intermediate thresholds were too lenient. This resulted in a new international NPS that can be applied to different contexts and to support a variety of health policies, to prevent both undernutrition and obesity. It can effi-ciently evaluate mixed food products and represents a flexible tool, applicable in various settings and populations. © 2021 by the authors. Licensee MDPI, Basel, Switzerland.

Dietary pattern analysis represents a useful improvement in the investigation of diet and health relationships. Particularly, the Mediterranean diet pattern has been associated with reduced mortality risk in several studies involving both younger and elderly population groups. In this research, relationships between dietary macronutrient composition, as well as the Mediterranean diet, and total mortality were assessed in 1,037 seventy-year-old subjects (540 females) information. Diet macronutrient composition was not associated with mortality, while a refined version of the modified Mediterranean diet index showed a significant inverse association (HR = 0.93, 95% CI: 0.89; 0.98). As expected, inactive subjects, smokers and those with a higher waist circumference had a higher mortality, while a reduced risk characterized married and more educated people. Sensitivity analyses (which confirmed our results) consisted of: exclusion of one food group at a time in the Mediterranean diet index, exclusion of early deaths, censoring at fixed follow-up time, adjusting for activities of daily living and main cardiovascular risk factors including weight/waist circumference changes at follow up. In conclusion, we can reasonably state that a higher adherence to a Mediterranean diet pattern, especially by consuming wholegrain cereals, foods rich in polyunsaturated fatty acids, and a limited amount of alcohol, predicts increased longevity in the elderly.