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  • 2101.
    Widström, Ann-Marie
    et al.
    Division of Reproductive and Perinatal Health Care, Department of Woman's and Children's Health, Karolinska Institutet, Retzius väg 13 A, 171 77 Stockholm, Sweden.
    Lilja, Gunilla
    Division Nursing, Department of Neurobiology, Care Science and Society, Karolinska Institutet, S-17177 Stockholm, Sweden.
    Aaltomaa-Michalias, P.
    Södersjukhuset, Stockholm, Sweden.
    Dahllöf, A.
    Södersjukhuset, Stockholm, Sweden.
    Lintula, M.
    Karolinska University Hospital, Stockholm, Sweden.
    Nissen, Eva
    University of Skövde, School of Life Sciences.
    Newborn behaviour to locate the breast when skin-to-skin: a possible method for enabling early self-regulation2011In: Acta Paediatrica, ISSN 0803-5253, E-ISSN 1651-2227, Vol. 100, no 1, p. 79-85Article in journal (Refereed)
    Abstract [en]

    Aim: The aim of this study was to provide a more detailed analysis of the infant’s behavioural sequence that begins immediately after birth and terminates with grasping the nipple, suckling and then falling asleep. Method:Twenty-eight full-term infants were videotaped immediately after birth. A video protocol was developed to examine infant behaviours identified from five random videotapes. Results:When birth crying had stopped, the babies showed a short period of relaxation and then successively became alert. They went through an ‘awakening phase’, an ‘active phase’ with movements of limbs, rooting activity and looking at the mother’s face, a ‘crawling phase’ with soliciting sounds, a ‘familiarization phase’ with licking of the areola, and a ‘suckling phase’ and last a ‘sleeping phase’. Five factors related to the time spent to locate the breast: more number of looks at the breast 10–20 min after birth (p < 0.0001); and exposure to meperidine (p = 0.0006) related to increased time. Early start of crawling (p = 0,0040); increased number of ‘soliciting sounds’ (p = 0.0022); and performing hand–breast–mouth movements (p = 0.0105) related to shorter time. Conclusion:  Inborn breastfeeding reflexes were depressed at birth, possibly because of a depressed sensory system. It is hypothesized that when the infant is given the option to peacefully go through the nine behavioural phases birth cry, relaxation, awakening, activity, crawling, resting, familiarization, suckling and sleeping when skin-to-skin with its mother this results in early optimalself-regulation.

  • 2102.
    Wigholm, Anne-Marie
    et al.
    University of Skövde, School of Health and Education.
    Österlund, Felicia
    University of Skövde, School of Health and Education.
    Kvinnors upplevelser av övervikt och fetmas påverkan på deras vardag: - en analys av bloggar skrivna av kvinnor.2015Independent thesis Basic level (university diploma), 10 credits / 15 HE creditsStudent thesis
    Abstract [en]

    Title:                                   Women's experiences of overweight and obesity's affects on                                  their the daily life - an analysis of blogs written by women.

    Authors:                            Wigholm, Ann-Marie; Österlund, Felicia

    Department:                      Nursing school of health and education, University of Skövde

    Course:                              Degree of Bachelor of Science in Nursing, Thesis in Nursing Care, 15 hp

    Supervisor:                        Lund, Annelise, Tilly

    Examiner:                          Brovall, Maria

    Pages:                                 23

    Date:                                  150422

    Keywords:                         Healt, obesity, overweight, suffering, unhealth

     

     

    Background: Overweight and obesity have increased and become a public health problem in the society. The problem can lead to suffering by the individual, both physically and mentally. In order to maintain good health and avoid overweight and obesity a healthy lifestyle has great importance. The nurse has an important role to support and motivate the patient to achieve physical and mental well-being. Aim: To illustrate women's experience of overweight and obesity's affects on their daily lives. Method: A qualitative method according to Lundman and Hällgren- Graneheim of blog texts written by women has been used. Results: In the result three categories could be identified, who described how women were affected in their daily lives. Which were "Encumbrance on the own body in the everyday life", "Impressions from the environment" and "The ever-changing self-esteem." The theme that appeared was "Physical and psychological impact in the everyday life", beacause all of the women showed different degrees of mental illness. Discussion: Women with overweight and obesity felt differently treated in the environment, their daily life was affected in such a way that their physical and mental well-being deteriorated . Conclusion: The women had a reduced physical and mental well-being, therefore, resources should be put in to increased knowledge of nurses regarding communication and mental illness.

  • 2103.
    Wiklund, Liselotte
    University of Skövde, School of Bioscience.
    Premenstrual Dysphoric Disorder: A Review of Neural and Cognitive Changes in Women with PMDD2017Independent thesis Basic level (degree of Bachelor), 15 credits / 22,5 HE creditsStudent thesis
    Abstract [en]

    Around 3-8% of all women in reproductive age suffer from premenstrual dysphoric disorder (PMDD) which disenables them to live an ordinary life during the luteal phase (premenstrual phase) of the menstrual cycle. Throughout the premenstrual phase these women experience emotional, cognitive and physiological changes. Hitherto, the etiology of this disorder is unknown. Some consider the source of this state as non-biological, claiming that PMDD is a social construction imbedded in gender roles, that suggests that women should not show aggressive behavior or depressive mood unless it is during the premenstrual stage. Contradictory, research made in cognitive neuroscience claim that the origin is biological. It is assumed that the increased symptoms in women with PMDD is a result from dysfunctional sensitivity for the progesterone metabolite allopregnanolone that has a receptor in the GABAA system, hence, producing an anxious effect from high levels of allopregnanolone instead of the expected sedative, soothing effects. Research suggest that structural and functional changes occur in brain areas such as the hippocampus, parahippocampus, amygdala, cerebellum as well as in brainderived neurotrophic factor which is important for brain plasticity, growth and survival of neurons. Cognitive behaviors such as anticipation for negative stimuli, working memory and lack of cognitive control also seem to be affected by PMDD. Nonetheless, the evidence is inconsistent, the area of research face multiple issues in regards to study designs, hence making generalization at this point difficult. In sum, this essay reviews recent studies conducted in neuroscience of cognitive changes in women with PMDD, with focus on functional, structural and behavioral changes between the phases of the cycle.

  • 2104.
    Wilhelmsson, Emilie
    et al.
    University of Skövde, School of Life Sciences.
    Wååg, Maria
    University of Skövde, School of Life Sciences.
    Sjuksköterskors bedömning och hantering av undernutrition hos äldre patienter som vårdas på sjukhus: Enkätstudie2008Independent thesis Basic level (degree of Bachelor), 10 credits / 15 HE creditsStudent thesis
    Abstract [en]

    In spite of the fact the situation has been well known for several years, more than 25 percent of elderly patients suffer from malnutrition during hospital care. The aim of this study was to describe the nurse's assessment of nutrition status among elderly patients treated in hospital. The chosen method was a qualitative questionnaire and by using a qualitative content analysis, the answers were processed. The results were presented in seven themes; The clinical eye, Resources, Raised assessment, Registration of food intake, Mental health, Assistant nurse´s role and Lack of time. Our conclusion is that nurses have enough knowledge and aid to appraise an adequate nutrition status on their patients, but is prevented by constant lack of time resulting in nutrition questions being lower prioritized. Instead, the assistant nurse takes more responsibility for the nutrition assessment.

  • 2105.
    Wilhsson, Marie
    Högskolan i Halmstad.
    Ungdomars strävan mot att lyckas och nå framgång i livet: skolan som hälsofrämjande arena2017Doctoral thesis, comprehensive summary (Other academic)
    Abstract [sv]

    Syfte: Avhandlingens övergripande syfte var att öka kunskapen om perspektiv på ungdomars hälsa som utgångspunkt för att utveckla hälsofrämjande insatser i skolan. Metod: Studie I hade en kvantitativ beskrivande tvärsnittsdesign. Datamaterialet inhämtades från 948 ungdomar (11-15 år) som analyserades med multivariat logistik regressionsanalys. Studie II hade en kvalitativ utforskande design. Datamaterialet inhämtades från 117 ungdomar (14-17 år) och analyserades med grundad teori. Studie III hade en kvalitativ beskrivande design. Datamatmaterialet inhämtades från 42 ungdomar (14-15 år) och analyserades med kvalitativ innehållsanalys. Studie IV hade en kvalitativ beskrivande design. Datamaterialet inhämtades från 27 intressenter och analyserades med kvalitativ innehållsanalys. Resultat: Ungdomarna strävar mot att lyckas och att bli framgångsrika i nuet och i framtiden. En strävan som för ungdomarna upplevs som en kamp om sin tid, en kamp som de hanterar genom att använda sig av olika strategier för att balansera skolarbete och fritid. Flickors strävan handlar om att nå framgång i skolan för att bli självständig i framtiden. För pojkarna innebär framgång att bli framgångsrika inom någon av sina fritidsaktiviteter så som sport, som visar deras fysiska styrka. Framgång i nuet är av betydelse för pojkarna till skillnad från flickorna som ser på sin framgång i ett längre perspektiv. Det hälsofrämjande arbetet bör inrikta sig på att stödja ungdomars känsla av sammanhang och stärka optimism redan tidigt i tonåren samt synliggöra organisatoriska och kontextuella strukturer och normer som påverkar flickors och pojkars hälsa och livsstil. Konklusion:Sammanfattningsvis visar avhandlingen att perspektiv på ungdomars hälsa bör förstås på olika nivåer i samhället och också inkluderar perspektiv på kön. Vidare bör faktorer som är av betydelse för ungdomars livsstil diskuteras utifrån ett salutogent perspektiv och det hälsofrämjande arbetet i skolan bör utveckla insatser med kontextuella och könsspecifika utgångspunkter för att främja flickors och pojkars hälsa och livsstil.

  • 2106.
    Wilhsson, Marie
    et al.
    School of Social and Health Sciences, Halmstad University, Sweden.
    Svedberg, Petra
    School of Social and Health Sciences, Halmstad University, Sweden.
    Carlsson, Ing-Marie
    School of Social and Health Sciences, Halmstad University, Sweden.
    Högdin, Sara
    School of Social and Health Sciences, Halmstad University, Sweden.
    Nygren, Jens M.
    School of Social and Health Sciences, Halmstad University, Sweden.
    Handling Demands of Success Among Girls and Boys in Primarly School: A Conceptual Model2017In: Journal of School Nursing, ISSN 1059-8405, E-ISSN 1546-8364, Vol. 33, no 4, p. 316-325Article in journal (Refereed)
    Abstract [en]

    Stress among adolescents in Western societies is becoming an issue of increasing concern, and the global trend of adolescents’ health shows a gradual deterioration that is independent of national differences and increases with age. The aim of this study was to explore the main concern of adolescents and about how they cope with demands in everyday life. Participants were 14–16 years old, and data were collected from three sources. A constructivist grounded theory was used as a method for generating a model of the adolescents’ description of how they cope with demands in their everyday lives. The main concern described by participants in this study was to strive to be successful and to succeed in the present and throughout their lives. We conclude that differences between girls and boys, in terms of coping with demands in their everyday lives, are important to consider in the development of health promotion initiatives targeted at adolescents. 

  • 2107.
    Wilhsson, Marie
    et al.
    Halmstad University, School of Social and Health Sciences (HOS), Centre of Research on Welfare, Health and Sport (CVHI).
    Svedberg, Petra
    Halmstad University, School of Social and Health Sciences (HOS), Centre of Research on Welfare, Health and Sport (CVHI).
    Högdin, Sara
    Halmstad University, School of Social and Health Sciences (HOS), Centre of Research on Welfare, Health and Sport (CVHI).
    Nygren, Jens
    Halmstad University, School of Social and Health Sciences (HOS), Centre of Research on Welfare, Health and Sport (CVHI).
    Halmstad project: a participatory intervention to promote children’s mental health2013In: 21st International Conference on Health Promoting Hospitals and Health Services: Abstract book / [ed] Jürgen M. Pelikan, Christina Dietscher, WHO-CC , 2013, p. 123-123Conference paper (Refereed)
  • 2108.
    Wilhsson, Marie
    et al.
    Högskolan i Halmstad.
    Svedberg, Petra
    Högskolan i Halmstad.
    Högdin, Sara
    Högskolan i Halmstad.
    Nygren, Jens
    Högskolan i Halmstad.
    Halmstadprojektet – en deltagarstyrd intervention för att främja barns psykiska hälsa2013Conference paper (Refereed)
  • 2109.
    Wilhsson, Marie
    et al.
    Halmstad University, Sweden.
    Svedberg, Petra
    Halmstad University, Sweden.
    Högdin, Sara
    Halmstad University, Sweden.
    Nygren, Jens
    Halmstad University, Sweden.
    Handling demands on success among girls and boys in primarly school – a conceptual model2016Conference paper (Refereed)
    Abstract [en]

    Background: Stress among adolescents in Western societies is becoming an issue of increasing concern and the global trend of adolescents’ health shows a gradual deterioration that is independent of national differences and increases with age. Research shows that many adolescents report high levels of stress, associated with a change in expectations about performance and an increased focus on school results. Purpose/methods: The aim of this study was to explore the main concern of adolescents to get a deeper knowledge on how they cope with demands in everyday life. Grounded theory was used as a method to generate a model. Results: The core category “striving to be successful and to succeed” explains participants’ main concern in their everyday lives as a continuous process aiming for success in the present and to succeed throughout their lives. The category is what the participants describe as a race against time and can be divided into the two conceptual categories “struggling with time” and “separating life into different worlds”, pronouncing how they struggle and cope with their main concern in order to obtain wellbeing. Our results show a difference between how girls and boys cope with their demands. Conclusions: We show that girls and boys used different strategies to cope with stress in their everyday life. The results are based on adolescent’s experiences and are therefore an important contribution for initiating interventions aimed at promoting adolescents mental health from a gender perspective.

  • 2110.
    Wilhsson, Marie
    et al.
    School of Social and Health Sciences, Halmstad University, Sweden.
    Svedberg, Petra
    School of Social and Health Sciences, Halmstad University, Sweden.
    Högdin, Sara
    School of Social and Health Sciences, Halmstad University, Sweden.
    Nygren, Jens M.
    School of Social and Health Sciences, Halmstad University, Sweden.
    Girls and boys strategies to handle and cope with school-related stress2016In: European Journal of Public Health, ISSN 1101-1262, E-ISSN 1464-360X, Vol. 26, no Suppl. 1, p. 221-221Article in journal (Refereed)
    Abstract [en]

    Background A trend of increased stress and deteriorating mental health of adolescents is a global challenge (Currier et al, 2012). Research shows that many adolescents report high levels of stress associated with an increased focus on school performance (Moknes et al, 2014). These demands generally have a stronger impact on girl’s health (Låftman &amp; Modig, 2013) due to context and social construction of norms, values and beliefs about femininity and masculinity (Connell, 2002; Butler, 1999). The aim was to get a deeper understanding of girls and boys perceptions of how they handle demands and school-related stress. Methods This study has an explorative design and was analyzed by qualitative content analysis described by Graneheim and Lundman (2004). The participants were 42 adolescents 15 years old, interviewed in five focus groups, dived by gender from five randomly selected schools. Two additional gender mixed focus groups with 14 adolescents 15 years old, were recruited from two of the randomly selected schools. Results The results show that girls and boys handle school-related stress by using similar strategies, but in different ways. Girls express that they have to prioritize to deselect activities they use to do to handle demands from school, and boys prioritize their own activities to obtain strength to cope with demands. Girls often think about their future while boys more often live in present time, and don’t worry so much about the future. Girls receive social support and recovery from friends and family, while boys do various activities with their friends and family to get energy. Conclusions This study shows that girls and boys used different strategies to handle demand and school-related stress. The results are based on adolescent’s experiences and could therefore be an important foundation for interventions that promote adolescents capabilities to cope with increasing demands and to handle school-related stress. Key messages: This study shows that girls and boys perceived and used different strategies to handle demand and school-related stress The result is an important foundation for interventions that promote adolescents capabilities to cope with increasing demands and to handle school-related stress © The Author 2016.

  • 2111.
    Wilhsson, Marie
    et al.
    School of Social and Health Sciences, Halmstad University, Sweden.
    Svedberg, Petra
    School of Social and Health Sciences, Halmstad University, Sweden.
    Högdin, Sara
    School of Social and Health Sciences, Halmstad University, Sweden.
    Nygren, Jens M.
    School of Social and Health Sciences, Halmstad University, Sweden.
    Strategies of Adolescent Girls and Boys for Coping With School-Related Stress2017In: Journal of School Nursing, ISSN 1059-8405, Vol. 33, no 5, p. 374-382Article in journal (Refereed)
    Abstract [en]

    Stress among adolescents in Western societies is becoming an issue of increasing concern of adolescent’s health. The aim of this study was to gain greater knowledge about how girls and boys perceive and cope with school-related stress. Participants were 14- to 15-year-old adolescents from a medium-sized municipality in southern Sweden. The data were collected from focus group interviews. The data were subjected to qualitative content analysis. The findings show that adolescents ‘‘prioritizing the future or the present by making choices, finding their own private sphere to relax, and recovering with family and friends.’’ There were gender differences in how these strategies were used. The findings could be used for initiating and planning health promotion interventions in school with focus on supporting girls’ and boys’ equal terms to cope with school-related stress in present and for the future and to give equal condition for future studies and opportunities in life. 

  • 2112.
    Wilhsson, Marie
    et al.
    School of health and welfare, Halmstad University, Sweden.
    Svedberg, Petra
    School of health and welfare, Halmstad University, Sweden.
    Nygren, Jens M.
    School of health and welfare, Halmstad University, Sweden.
    A stakeholder perspective on adolescents’ needs for support to cope with school-related stressManuscript (preprint) (Other academic)
    Abstract [en]

    Background; Adolescents’ experiences of stress have increased in recent decades and is associated with an increase of psychosomatic symptoms and poorer academic achievement. Identification of ways to support adolescents’ handling of school related stress is a major challenge to promote their health and academic achievement. The purpose of this study was to describe the stakeholder’s perspectives on services that are needed for supporting adolescents in secondary school when coping with school-related stress. Methods; Representatives from the school health service and school management organization (n=23) from five secondary schools and parents (n=4) were recruited by snowball sampling. Interviews were analyzed by qualitative content analysis with an inductive approach.   Results; The study highlight different aspects of stakeholders’ perceptions of what is needed to support adolescents who experience school-related stress. Described are actions such as highlighting and changing organizational and contextual structures and developing the dialogue between the school and the home. Other described actions are to support adolescents’ abilities to plan and visualizing how time is used and to strengthen their adolescents’ belief in their own abilities. Conclusions; Our findings could be used in schools for developing interventions from a salutogenic approach to promote adolescents’ health in the present and for the future.

  • 2113.
    Wilsson, Margareta
    et al.
    University of Skövde, School of Life Sciences. Primary Health, Mariestad, Sweden.
    Adolfsson, Annsofie
    University of Skövde, School of Life Sciences. Department of Obstetrics and Gynecology, Skaraborg Hospital, Skövde, Sweden.
    Mother’s need of support and their expectations of the BVC nurse at the first home visit: an interview study2011In: Open Journal of Nursing, ISSN 2162-5336, E-ISSN 2162-5344, Vol. 1, no 3, p. 1-8Article in journal (Refereed)
    Abstract [en]

    One of the main priorities of the child healthcare services in Sweden is a home visit by the Child Health Care (BVC) nurse to newborn babies and their parents. It is essential that the BVC nurses have a comprehensive knowledge of the parent’s need of support and their expectations as new parents in order to be able to fulfill their needs. The aim of this study was to describe what type of support the mothers of infant children are in need of and what their expectations are of the BVC nurse when it is time for the home visit from the nurse. In this qualitative study twelve women were interviewed within one to two weeks after delivering a baby. The transcripts were analyzed using qualitative content analysis. The study shows that mothers who have previously given birth to children feel more secure in their parental role compared to what they experienced as first time mothers. The findings include that first time mother’s experienced uncertainty in their new role as a mother and caring for a baby. Parents seek support from the BVC nurse and they expect her behavior and attitude towards them to be friendly and professional. The fact that she is privy to personal knowledge of the family gives the parents a feeling of security when they contact the child healthcare center for various reasons. The mother’s need for support to develop as a parent and to feel secure in the parental role was a reoccurring theme in the interviews and became the theme of the study.

  • 2114.
    Wingbro-Carlsson, Gunilla
    et al.
    University of Skövde, School of Health and Education.
    Matsson, Lena
    University of Skövde, School of Health and Education.
    Skolsköterskors hälsofrämjande arbete för barn med ADHD2016Independent thesis Advanced level (degree of Master (One Year)), 10 credits / 15 HE creditsStudent thesis
    Abstract [en]

    Attention Deficit / Hyperactivity Disorder (ADHD) is an attention deficit hyperactivity disorder that affects approximately 3-5 percent of school-age children. The school has an important influence on children's lives and there is a correlation between students' mental health and school performance. School nurses have an important role as health promoters, especially when children with ADHD are at increased risk of ill health and risky behavior.

     

    Aim: The aim of this study was to describe the school nurses´ experiences of working with measures for children with ADHD.

     

    Method: The study was conducted using a qualitative method. The study is based on telephone interviews with eight school nurses, which have been analyzed using qualitative content analysis.

     

    Results: Five categories emerged from the analysis, which describes the school nurses´ experiences of working with various measures for children with ADHD; Working together through dialogue, to adapt the school environment, provide guidance and advice to parents and children, to observe and implement controls and to work specifically with health promotion.

     

    Conclusion: School nurses have experience of different types of measures for children with ADHD. They stressed in particular the importance of paying attention to children with ADHD and regular health discussions.

  • 2115.
    Winter, Kristoffer
    et al.
    University of Skövde, School of Health and Education.
    Millton, Ludvig
    University of Skövde, School of Health and Education.
    Att leva med hjärtsvikt: En litteraturöversikt2019Independent thesis Basic level (degree of Bachelor), 10 credits / 15 HE creditsStudent thesis
    Abstract [en]

    Background: Heart failure is a common illness, especially among elderly people. The illness is classified using the New York Heart Association Functional Classification (NYHA) and is treated using a variety of different treatment regimes. Person centered care is important to facilitate high standard care and promote the intrinsic value of the individual. Nurses and relatives play an important role in caring for people with heart failure. Aim: To describe how people over 18 years of age experience living with heart failure. Method: A review of the literature based on 15 scientific articles. Results: People experience fatigue and breathlessness as the most prominent symptoms. Breathlessness is in many cases initially difficult to attribute to heart failure and is a source of anxiety. Fatigue is experienced as a physical tiredness that leads to feelings of hopelessness. People feel misunderstood by people around them on how much fatigue affects their daily lives. Heart failure leads to physical limitations and affects daily activities negatively. This leads to feelings of limitations, poor self-image, reduced quality of live and loneliness. Conclusion: Heart failure affects people on many different levels. People experience breathlessness and fatigue to be the more difficult symptoms of heart failure and it being limiting on daily activities.

  • 2116.
    Wirheim, Elin
    et al.
    University of Skövde, School of Life Sciences.
    Menze, Therese
    University of Skövde, School of Life Sciences.
    PATIENTERS UPPLEVELSER AV ATT VÅRDAS FÖR BIPOLÄR SJUKDOM: En studie gjord på självbiografiska böcker2013Independent thesis Basic level (degree of Bachelor), 10 credits / 15 HE creditsStudent thesis
    Abstract [en]

    The background to this study was that bipolar disorder is one of the twenty most common reasons of disability in the world. There are few studies made on the subject of patients with bipolar disorder owns experience of the given healthcare. Caregivers will meet these patients in all kind of healthcare. The purpose of this study is to describe how patients with bipolar disorder experience their need of support and care. A qualitative literature method was used, where seven autobiographies where analyzed. The result summarized in five main themes: life rhythm and balance, barriers to seek care when the need exist, the need of support, need to comfortable points and different ways to be treated with dignity and listened to. The discussion demonstrated the significant of the result, patients with bipolar disorder finds it difficult to take in information when they have both a manic and a depressive episode. It is important that nurses have patience and understanding for the patient's life and his or her illness. The nurses have to understand the meaning of giving individual information and support to the patient.

  • 2117.
    Wixtröm, Marie-Christin
    et al.
    University of Skövde, School of Life Sciences.
    Svensson, Magnus
    University of Skövde, School of Life Sciences.
    "Anhörigas behov när en närstående vårdas på hospice": en litteraturstudie2009Independent thesis Basic level (degree of Bachelor), 10 credits / 15 HE creditsStudent thesis
    Abstract [en]

    Hospice started in the late 1960s. This cares aim is to create a good quality at the end-oflife. One of the pillars of this care is to allow the relatives to take part in the care around the patient. This study aim is to highlight the relative's needs in care for at hospice. The study is a literature review, based on scientific articles. The analysis resulted in four themes, which are information and communication, relative's involvement in care, the relative's experiences and nurse's support to the relatives. It came up that information and communication are of great importance. Both patients and their relatives wanted a little less information and many briefings. The involvement in care can give the relatives a chance to begin to grief. Relatives can need the support from the nurse in their situation. It is generally accepted that patients are well taken care of at the hospice, but what about the experience for the relative's involved in the care of their loved ones? Is it only positive to be close to the patient all the time, or are there also negative sides?

  • 2118.
    Wojnar, Danuta M.
    et al.
    Seattle Univ, Coll Nursing, Seattle, WA 98122 USA.
    Swanson, Kristen M.
    Univ N Carolina, Sch Nursing, Chapel Hill, NC USA.
    Adolfsson, Ann-Sofie
    University of Skövde, School of Life Sciences.
    Confronting the inevitable: A conceptual model of miscarriage for use in clinical practice and research2011In: Death Studies, ISSN 0748-1187, E-ISSN 1091-7683, Vol. 35, no 6, p. 536-558Article in journal (Refereed)
    Abstract [en]

    In spite of scientific evidence that miscarriage has negative psychological consequences for many individuals and couples, silence and dismissal continue to surround this invisible loss in North American culture and beyond. The grief and sorrow of miscarriage has important implications for clinical practice. It indicates a need for therapeutic interventions delivered in a caring, compassionate, and culturally sensitive manner. This research, based on data from 3 phenomenological investigations conducted with 42 women from diverse geographical locations, sexual orientations, and cultural backgrounds offers a theoretical framework for addressing miscarriage in clinical practice and research.

  • 2119.
    Wolters, M.
    et al.
    Leibniz Inst Prevent Res & Epidemiol BIPS, D-28359 Bremen, Germany.
    Schlenz, H.
    Leibniz Inst Prevent Res & Epidemiol BIPS, D-28359 Bremen, Germany.
    Foraita, R.
    Leibniz Inst Prevent Res & Epidemiol BIPS, D-28359 Bremen, Germany.
    Galli, C.
    Univ Milan, Dept Pharmacol & Biomol Sci, DiSFeB, Milan, Italy.
    Rise, P.
    Univ Milan, Dept Pharmacol & Biomol Sci, DiSFeB, Milan, Italy.
    Moreno, L. A.
    Univ Zaragoza, Growth Exercise Nutr & Dev GENUD Res Grp, Zaragoza, Spain.
    Molnar, D.
    Univ Pecs, Natl Inst Hlth Promot, Pecs, Hungary.
    Russo, P.
    CNR, Inst Food Sci, Epidemiol & Populat Genet, Avellino, Italy.
    Veidebaum, T.
    Natl Inst Hlth Dev, Dept Chron Dis, Tallinn, Estonia.
    Tornaritis, M.
    Res & Educ Inst Child Hlth, Strovolos, Cyprus.
    Vyncke, K.
    Univ Ghent, Dept Publ Hlth, Fac Med & Hlth Sci, B-9000 Ghent, Belgium.
    Eiben, Gabriele
    Queen Silvia Childrens Hosp, Dept Publ Hlth & Community Med, Gothenburg, Sweden.
    Iacoviello, L.
    IRCCS Ist Neurol Mediterraneo Neuromed, Dept Epidemiol & Prevent, Lab Mol & Nutr Epidemiol, Pozzilli, Italy.;Casa Cura Montevergine, Lab Cardiovasc & Neurovasc Epidemiol, Mercogliano, Italy.
    Ahrens, W.
    Leibniz Inst Prevent Res & Epidemiol BIPS, D-28359 Bremen, Germany.;Univ Bremen, Fac Math & Comp Sci, Inst Stat, D-28359 Bremen, Germany.
    Reference values of whole-blood fatty acids by age and sex from European children aged 3-8 years2014In: International Journal of Obesity, ISSN 0307-0565, E-ISSN 1476-5497, Vol. 38, p. S86-S98Article in journal (Refereed)
    Abstract [en]

    OBJECTIVES: To establish reference values for fatty acids (FA) especially for n-3 and n-6 long-chain polyunsaturated FAs (LC PUFA) in whole-blood samples from apparently healthy 3-8-year-old European children. The whole-blood FA composition was analysed and the age-and sex-specific distribution of FA was determined. DESIGN AND SUBJECTS: Blood samples for FA analysis were taken from 2661 children of the IDEFICS (identification and prevention of dietary-and lifestyle-induced health effects in children and infants) study cohort. Children with obesity (n = 454) and other diseases that are known to alter the FA composition (n = 450) were excluded leaving 1653 participants in the reference population. MEASUREMENTS: The FA composition of whole blood was analysed from blood drops by a rapid, validated gas chromatographic method. RESULTS: Pearson correlation coefficients showed an age-dependent increase of C18:2n-6 and a decrease of C18:1n-9 in a subsample of normal weight boys and girls. Other significant correlations with age were weak and only seen either in boys or in girls, whereas most of the FA did not show any age dependence. For age-dependent n-3 and n-6 PUFA as well as for other FA that are correlated with age (16:0, C18:0 and C18:1n-9) percentiles analysed with the general additive model for location scale and shape are presented. A higher median in boys than in girls was observed for C20:3n-6, C20:4n-6 and C22:4n-6. CONCLUSIONS: Given the reported associations between FA status and health-related outcome, the provision of FA reference ranges may be useful for the interpretation of the FA status of children in epidemiological and clinical studies.

  • 2120.
    Wolters, Maike
    et al.
    Leibniz Inst Prevent Res & Epidemiol BIPS, Bremen, Germany.
    Boernhorst, Claudia
    Leibniz Inst Prevent Res & Epidemiol BIPS, Bremen, Germany.
    Schwarz, Heike
    Leibniz Inst Prevent Res & Epidemiol BIPS, Bremen, Germany.
    Rise, Patrizia
    Univ Milan, Dept Pharmacol & Biomol Sci, DiSFeB, Milan, Italy.
    Galli, Claudio
    Univ Milan, Dept Pharmacol & Biomol Sci, DiSFeB, Milan, Italy.
    Moreno, Luis A.
    Univ Zaragoza, Growth Exercise Nutr & Dev GENUD Res Grp, Zaragoza, Spain.
    Pala, Valeria
    Fdn IRCCS Ist Nazl Tumori, Dept Prevent & Predict Med, Epidemiol & Prevent Unit, Milan, Italy.
    Russo, Paola
    CNR, Inst Food Sci, Epidemiol & Populat Genet, Avellino, Italy.
    Veidebaum, Toomas
    Natl Inst Hlth Dev, Tallinn, Estonia.
    Tornaritis, Michael
    Res & Educ Inst Child Hlth, Strovolos, Cyprus.
    Fraterman, Arno
    Med Versorgungszentrum Dr Eberhard & Partner Dort, Lab Med, Dortmund, Germany.
    De Henauw, Stefaan
    Univ Ghent, Fac Med & Hlth Sci, Dept Publ Hlth, Ghent, Belgium.
    Eiben, Gabriele
    Univ Gothenburg, Sahlgrenska Acad, Inst Med, Sect Epidemiol & Social Med, Gothenburg, Sweden.
    Lissner, Lauren
    Univ Gothenburg, Sahlgrenska Acad, Inst Med, Sect Epidemiol & Social Med, Gothenburg, Sweden.
    Molnar, Denes
    Univ Pecs, Natl Inst Hlth Promot, Pecs, Hungary.
    Ahrens, Wolfgang
    Leibniz Inst Prevent Res & Epidemiol BIPS, Bremen, Germany.;Univ Bremen, Inst Stat, Fac Math & Comp Sci, Bremen, Germany.
    Association of desaturase activity and C-reactive protein in European children2017In: Pediatric Research, ISSN 0031-3998, E-ISSN 1530-0447, Vol. 81, no 1, p. 27-32Article in journal (Refereed)
    Abstract [en]

    BACKGROUND: Desaturase enzymes influence the fatty acid (FA) composition of body tissues and their activity affects the conversion rate of saturated to monounsaturated FA and of polyunsaturated FA (PUFA) to long-chain PUFA. Desaturase activity has further been shown to be associated with inflammation. We investigate the association between delta-9 (D9D), delta-6 (D6D) and delta-5 desaturase (D5D) activity and high sensitive C-reactive protein (CRP) in young children. METHODS: In the IDEFICS (Identification and prevention of dietary- and lifestyle-induced health effects in children and infants) cohort study children were examined at baseline (TO) and after 2 y (T1). D9D, D6D, and D5D activities were estimated from TO product-precursor FA ratios. CRP was measured at TO and T1. In a subsample of 1,943 children with available information on FA, CRP, and covariates, the cross-sectional and longitudinal associations of desaturase activity and CRP were analyzed. RESULTS: Cross-sectionally, a D9D increase of 0.01 units was associated with a 11% higher risk of having a serum CRP Percentile 75 (P75) (OR, 99% CI: 1.11 (1.01; 1.22)) whereas D6D and D5D were not associated with CRP. No significant associations were observed between baseline desaturase activity and CRP 2 y later. CONCLUSION: Cross-sectionally, our results indicate a positive association of D9D and CRP independent of weight status. High D9D activity may increase the risk of subclinical inflammation which is associated with metabolic disorders. As D9D expression increases with higher intake of saturated FA and carbohydrates, dietary changes may influence D9D activity and thus CRP. However, it remains to be investigated whether there is a causal relationship between D9D activity and CRP.

  • 2121.
    Wongsala, Manothai
    et al.
    Mälardalen University.
    Anbäcken, Els-Marie
    Mälardalen University.
    Rosendahl, Sirpa
    University of Skövde, School of Health and Education. University of Skövde, Health and Education.
    Lomwong Saansook: Improving Health, Participation and Security Among Thai Older Adults Using PDSA Wheel2019Conference paper (Refereed)
  • 2122.
    Wongsala, Manothai
    et al.
    Mälardalen University, Sweden.
    Anbäcken, Els-Marie
    Mälardalen University, Sweden.
    Rosendahl, Sirpa
    University of Skövde, School of Health and Education. University of Skövde, Health and Education.
    Perspectives of Health, Participation and Security among Older Adults in Northeastern Thailand2018Conference paper (Other academic)
  • 2123.
    Wu, Jie
    et al.
    IMS Health Shanghai.
    Dalal, Koustuv
    University of Skövde, School of Life Sciences.
    Tuberculosis in Asia and the Pacific: The role of socioeconomic status and health system development2012In: International Journal of Preventive Medicine, ISSN 2008-7802, E-ISSN 2008-8213, Vol. 3, no 1, p. 8-16Article in journal (Refereed)
    Abstract [en]

    Objective: To identify the relationship between socioeconomic status, health system development and the incidence, prevalence and mortality of tuberculosis in Asia and the Pacific. Methods: Incidence, prevalence and mortality rates of tuberculosis and 20 variables of  socioeconomic, health system and biological behavioral issues were included in the study involving all 46 countries of  the Asian Development Bank region (2007 data). Both univariate and multivariate linear regressions were used. Results: The worst three tuberculosis affected countries were Cambodia, India and Indonesia, while the least affected was Australia. Tuberculosis incidence, prevalence and mortality rate were higher in countries with lower human development index, corruption perception index, gross domestic product (GDP) per capita and countries with more people under minimum food supplements. Among the health system variables, total health expenditure per capita, governmental health expenditure per capita, hospital beds, and access to improved water and sanitation were strongly associated with tuberculosis. Conclusions: Socioeconomic determinants and health system development have significant effect on the control of tuberculosis in Asia and the Pacific region. The study has some policy implications by means of  lowering the corruption and improving the sanitation.

  • 2124.
    Yang, Lie
    et al.
    Sichuan Univ, W China Hosp, Inst Digest Surg, Chengdu 610064, Sichuan Prov, Peoples R China / Sichuan Univ, W China Hosp, State Key Lab Biotherapy, Chengdu 610064, Sichuan Prov, Peoples R China / Linkoping Univ, Dept Oncol & Clin & Expt Med, SE-58185 Linkoping, Sweden .
    Zhang, Hong
    University of Skövde, The Systems Biology Research Centre. University of Skövde, School of Life Sciences.
    Zhou, Zong-Guang
    Sichuan Univ, W China Hosp, Inst Digest Surg, Chengdu 610064, Sichuan Prov, Peoples R China / Sichuan Univ, W China Hosp, State Key Lab Biotherapy, Chengdu 610064, Sichuan Prov, Peoples R China .
    Yan, Hui
    Sichuan Univ, W China Hosp, Inst Digest Surg, Chengdu 610064, Sichuan Prov, Peoples R China / Sichuan Univ, W China Hosp, State Key Lab Biotherapy, Chengdu 610064, Sichuan Prov, Peoples R China .
    Adell, Gunnar
    Karolinska Univ Hosp, Dept Oncol, Stockholm, Sweden.
    Sun, Xiao-Feng
    Sichuan Univ, W China Hosp, Inst Digest Surg, Chengdu 610064, Sichuan Prov, Peoples R China / Sichuan Univ, W China Hosp, State Key Lab Biotherapy, Chengdu 610064, Sichuan Prov, Peoples R China / Linkoping Univ, Dept Oncol & Clin & Expt Med, SE-58185 Linkoping, Sweden .
    Biological Function and Prognostic Significance of Peroxisome Proliferator-Activated Receptor delta in Rectal Cancer2011In: Clinical Cancer Research, ISSN 1078-0432, E-ISSN 1557-3265, Vol. 17, no 11, p. 3760-3770Article in journal (Refereed)
    Abstract [en]

    Purpose: To investigate the expression significance of PPAR beta/delta in relation to radiotherapy (RT), clinicopathologic, and prognostic variables of rectal cancer patients. Experimental Design: We included 141 primary rectal cancer patients who participated in a Swedish clinical trial of preoperative RT. Tissue microarray samples from the excised rectal cancers and the adjacent or distant normal mucosa and lymph node metastases were stained with PPAR delta antibody. Survival probability was computed by the Kaplan-Meier method and Cox regression model. The proliferation of colon cancer cell lines KM12C, KM12SM, and KM12L4a was assayed after PPAR delta knockdown. Results: PPAR delta was increased from adjacent or distant normal mucosa to primary cancers, whereas it decreased from primary cancers to lymph node metastases. After RT, PPAR delta was increased in normal mucosa, whereas it decreased in primary cancers and lymph node metastases. In primary cancers, the high expression of PPAR delta was related to higher frequency of stage I cases, lower lymph node metastasis rate, and low expression of Ki-67 in the unirradiated cases, and related to favorable survival in the cases either with or without RT. The proliferation of the KM12C, KM12SM, or KM12L4a cells was significantly accelerated after PPAR delta knockdown. Conclusions: RT decreases the PPAR delta expression in primary rectal cancers and lymph node metastases. PPAR delta is related to the early development of rectal cancer and inhibits the proliferation of colorectal cancer cells. Increase of PPAR delta predicts favorable survival in the rectal cancer patients either with or without preoperative RT. Clin Cancer Res; 17(11); 3760-70. (C)2011 AACR.

  • 2125.
    Ydreborg, Berit
    et al.
    Department of Community Medicine and Public Health, Örebro County Council, Örebro, Sweden / National Centre for Work and Rehabilitation, Department of Health and Society, Linköping University, Linköping, Sweden.
    Ekberg, Kerstin
    National Centre for Work and Rehabilitation, Department of Health and Society, Linköping University, Linköping, Sweden.
    Nilsson, Kerstin
    University of Skövde, School of Life Sciences.
    Swedish social insurance officers' experiences of difficulties in assessing applications for disability pensions: an interview study2007In: BMC Public Health, ISSN 1471-2458, E-ISSN 1471-2458, Vol. 7, p. 128-Article in journal (Refereed)
    Abstract [en]

    Background

    In this study the focus is on social insurance officers judging applications for disability pensions. The number of applications for disability pension increased during the late 1990s, which has resulted in an increasing number of disability pensions in Sweden. A more restrictive attitude towards the clients has however evolved, as societal costs have increased and governmental guidelines now focus on reducing costs. As a consequence, the quantitative and qualitative demands on social insurance officers when handling applications for disability pensions may have increased. The aim of this study was therefore to describe the social insurance officers' experiences of assessing applications for disability pensions after the government's introduction of stricter regulations.

    Methods

    Qualitative methodology was employed and a total of ten social insurance officers representing different experiences and ages were chosen. Open-ended interviews were performed with the ten social insurance officers. Data was analysed with inductive content analysis.

    Results

    Three themes could be identified as problematic in the social insurance officers' descriptions of dealing with the applications in order to reach a decision on whether the issue qualified applicants for a disability pension or not: 1. Clients are heterogeneous. 2. Ineffective and time consuming waiting for medical certificates impede the decision process. 3. Perspectives on the issue of work capacity differed among different stakeholders. The backgrounds of the clients differ considerably, leading to variation in the quality and content of applications. Social insurance officers had to make rapid decisions within a limited time frame, based on limited information, mainly on the basis of medical certificates that were often insufficient to judge work capacity. The role as coordinating actor with other stakeholders in the welfare system was perceived as frustrating, since different stakeholders have different goals and demands. The social insurance officers experience lack of control over the decision process, as regulations and other stakeholders restrict their work.

    Conclusion

    A picture emerges of difficulties due to disharmonized systems, stakeholder-bound goals causing some clients to fall between two stools, or leading to unnecessary waiting times, which may limit the clients' ability to take an active part in a constructive process. Increased communication with physicians about how to elaborate the medical certificates might improve the quality of certificates and thereby reduce the clients waiting time.

  • 2126.
    Yewale, Priti Prabhakar
    et al.
    Microbial Diversity Research Centre, Dr. D. Y. Patil Biotechnology and Bioinformatics Institute, Dr. D. Y. Patil Vidyapeeth, Pune, India.
    Lokhande, Kiran Bharat
    Bioinformatics Research Laboratory, Dr. D. Y. Patil Biotechnology and Bioinformatics Institute, Dr. D. Y. Patil Vidyapeeth, Pune, India.
    Sridhar, Aishwarya
    Microbial Diversity Research Centre, Dr. D. Y. Patil Biotechnology and Bioinformatics Institute, Dr. D. Y. Patil Vidyapeeth, Pune, India.
    Vaishnav, Monika
    Microbial Diversity Research Centre, Dr. D. Y. Patil Biotechnology and Bioinformatics Institute, Dr. D. Y. Patil Vidyapeeth, Pune, India.
    Khan, Faisal Ahmad
    The Life Science Centre-Biology, School of Science and Technology, Örebro University, Sweden.
    Mandal, Abul
    University of Skövde, School of Bioscience. University of Skövde, The Systems Biology Research Centre.
    Swamy, Kakumani Venkateswara
    Bioinformatics Research Laboratory, Dr. D. Y. Patil Biotechnology and Bioinformatics Institute, Dr. D. Y. Patil Vidyapeeth, Pune, India.
    Jass, Jana
    The Life Science Centre-Biology, School of Science and Technology, Örebro University, Sweden.
    Nawani, Neelu
    Microbial Diversity Research Centre, Dr. D. Y. Patil Biotechnology and Bioinformatics Institute, Dr. D. Y. Patil Vidyapeeth, Pune, India.
    Molecular profiling of multidrug-resistant river water isolates: insights into resistance mechanism and potential inhibitors2019In: Environmental science and pollution research international, ISSN 0944-1344, E-ISSN 1614-7499Article in journal (Refereed)
    Abstract [en]

    Polluted waters are an important reservoir for antibiotic resistance genes and multidrug-resistant bacteria. This report describes the microbial community, antibiotic resistance genes, and the genetic profile of extended spectrum β-lactamase strains isolated from rivers at, Pune, India. ESBL-producing bacteria isolated from diverse river water catchments running through Pune City were characterized for their antibiotic resistance. The microbial community and types of genes which confer antibiotic resistance were identified followed by the isolation of antibiotic-resistant bacteria on selective media and their genome analysis. Four representative isolates were sequenced using next generation sequencing for genomic analysis. They were identified as Pseudomonas aeruginosa, Escherichia coli, and two isolates were Enterobacter cloacae. The genes associated with the multidrug efflux pumps, such as tolC, macA, macB, adeL, and rosB, were detected in the isolates. As MacAB-TolC is an ABC type efflux pump responsible for conferring resistance in bacteria to several antibiotics, potential efflux pump inhibitors were identified by molecular docking. The homology model of their MacB protein with that from Escherichia coli K12 demonstrated structural changes in different motifs of MacB. Molecular docking of reported efflux pump inhibitors revealed the highest binding affinity of compound MC207-110 against MacB. It also details the potential efflux pump inhibitors that can serve as possible drug targets in drug development and discovery. 

  • 2127.
    Yngman-Uhlin, Pia
    et al.
    Linköping University, Department of Medical and Health Sciences, Faculty of Health Sciences, Linköping, Sweden / Department of Nephrology, University Hospital, Linköping, Sweden.
    Johansson, Anna
    Linköping University, Department of Medical and Health Sciences, Faculty of Health Sciences, Linköping, Sweden / Department of Cardiology, Skövde Hospital, Skövde, Sweden.
    Fernström, Anders
    Department of Nephrology, University Hospital, Linköping, Sweden.
    Börjeson, Sussanne
    Linköping University, Department of Medical and Health Sciences, Faculty of Health Sciences, Linköping, Sweden.
    Edéll-Gustafsson, Ulla
    Linköping University, Department of Medical and Health Sciences, Faculty of Health Sciences, Linköping, Sweden.
    Fragmented sleep: an unrevealed problem in peritoneal dialysis patients2011In: Scandinavian Journal of Urology and Nephrology, ISSN 0036-5599, E-ISSN 1651-2065, Vol. 45, no 3, p. 206-215Article in journal (Refereed)
    Abstract [en]

    OBJECTIVE: The aim of this study was to describe the sleep-wake cycle, sleep quality, fatigue and Health Related Quality of Life (HRQoL) measured with questionnaires, actigraphy and a sleep diary during a one-week period in patients undergoing peritoneal dialysis (PD) treatment at home. A further aim was to explore differences compared with patients with coronary artery disease (CAD) and individuals from the general population.

    MATERIAL AND METHODS: In this study one-week actigraphy registration, four questionnaires (Uppsala Sleep Inventory, SF-36, FACIT-fatigue, International Restless Legs Study Groups' form) and a sleep diary were used.

    RESULTS: Data from 68 participants and 470 nights were collected. PD patients (n = 28) had more fragmented sleep (p < 0.001) and worse sleep efficiency (SE%) (p < 0.0001) than the CAD (n = 22) and the population (n = 18) groups. Pruritus (57%), restless legs (46%) and fatigue (89%) were prevalent in PD patients. Pruritus correlated with fragmented sleep (r = -0.45, p = 0.01) and SE (r = -0.49, p = 0.01). In HRQoL, the physical component score was decreased in the PD and CAD groups (p < 0.01) compared to the population group.

    CONCLUSIONS: To the authors' knowledge this study is the first to demonstrate that PD patients have deteriorated sleep, with serious fragmentation measured by a one-week actigraphy registration. Further, PD patients exhibit worse sleep quality than CAD patients and individuals in the population. Evaluation of sleep in clinical practice is highly recommended since PD patients are vulnerable individuals with extended self-care responsibilities and at risk for comorbidity secondary to insufficient sleep. Future research on whether PD patients' sleep problems and fatigue can be improved by an individual non-pharmacological intervention programme is required.

  • 2128.
    Yngve, Sara
    University of Skövde, School of Bioscience.
    Optimization of PCR Sensitivity for Detection of Bacterial Species in Blood of Patients with Suspected Sepsis2015Independent thesis Advanced level (degree of Master (One Year)), 20 credits / 30 HE creditsStudent thesis
    Abstract [en]

    Sepsis is commonly caused by bacteria, fungi or both present in the blood stream during inflammation. In response, inflammatory cascades are released in multiple organ systems which if prolonged causes sepsis and can eventually lead to organ failure and death. The major diagnostic technique of sepsis is blood culturing. However, the technique is time consuming and lacks sensitivity; especially in patients under antimicrobial therapy. Molecular techniques particularly PCR could possibly become implemented in sepsis diagnostics in the future. The aim of the thesis was to compare the effect on PCR sensitivity by different PCR kits, with optimized PCR conditions to find an ideal Real-time PCR applicable for direct detection of rRNA or rDNA in whole blood, using the 16S rDNA gene. The study also surveyed the overall background flora of bacterial species circulating in the blood. During the optimization Haemophillus influenzae and Streptococcus pneumoniae were added to whole blood, rRNA or rDNA was isolated and extracted and subsequently processed by Real-time PCR. Four commercially available PCR kits were compared. Attempts using rRNA did not significantly increase the PCR sensitivity. LightCycler FastStart DNA Master SYBR Green I kit (Roche Diagnostics) used for rDNA, generated low cp-values, the cleanest sequences and the finest separation between amplification curves. Twenty whole blood and pre-cultured patient samples were processed by the optimized PCR. The effect on PCR sensitivity by pre-culturing patient blood samples was studied and no statistical difference was noted. Increased PCR sensitivity is essential for implementation of PCR techniques in sepsis diagnostics.

  • 2129.
    Zaqout, M.
    et al.
    Univ Ghent, Dept Publ Hlth, Fac Med & Hlth Sci, Ghent, Belgium.
    Michels, N.
    Univ Ghent, Dept Publ Hlth, Fac Med & Hlth Sci, Ghent, Belgium.
    Bammann, K.
    Univ Bremen, Inst Publ Hlth & Nursing Res, Fac Human & Hlth Sci, Bremen, Germany.;Leibniz Inst Prevent Res & Epidemiol BIPS, Bremen, Germany.
    Ahrens, W.
    Leibniz Inst Prevent Res & Epidemiol BIPS, Bremen, Germany.
    Sprengeler, O.
    Leibniz Inst Prevent Res & Epidemiol BIPS, Bremen, Germany.
    Molnar, D.
    Univ Pecs, Fac Med, Dept Pediat, Pecs, Hungary.
    Hadjigeorgiou, C.
    Res & Educ Inst Child Hlth, Strovolos, Cyprus.
    Eiben, Gabriele
    Univ Gothenburg, Sahlgrenska Acad, Dept Publ Hlth & Community Med, Publ Hlth Epidemiol Unit EPI, Gothenburg, Sweden.
    Konstabel, K.
    Natl Inst Hlth Dev, Dept Chron Dis, Ctr Behav & Hlth Sci, Tallinn, Estonia.
    Russo, P.
    CNR, Inst Food Sci, Unit Epidemiol & Populat Genet, Avellino, Italy.
    Jimenez-Pavon, D.
    Univ Zaragoza, GENUD Growth Exercise Nutr & Dev Res Grp, Zaragoza, Spain.
    Moreno, L. A.
    Univ Zaragoza, GENUD Growth Exercise Nutr & Dev Res Grp, Zaragoza, Spain.
    De Henauw, S.
    Univ Ghent, Dept Publ Hlth, Fac Med & Hlth Sci, Ghent, Belgium.
    Influence of physical fitness on cardio-metabolic risk factors in European children. The IDEFICS study2016In: International Journal of Obesity, ISSN 0307-0565, E-ISSN 1476-5497, Vol. 40, no 7, p. 1119-1125Article in journal (Refereed)
    Abstract [en]

    OBJECTIVE: The aim of the study was to assess the associations of individual and combined physical fitness components with single and clustering of cardio-metabolic risk factors in children. SUBJECTS/METHODS: This 2-year longitudinal study included a total of 1635 European children aged 6-11 years. The test battery included cardio-respiratory fitness (20-m shuttle run test), upper-limb strength (handgrip test), lower-limb strength (standing long jump test), balance (flamingo test), flexibility (back-saver sit-and-reach) and speed (40-m sprint test). Metabolic risk was assessed through z-score standardization using four components: waist circumference, blood pressure (systolic and diastolic), blood lipids (triglycerides and high-density lipoprotein) and insulin resistance (homeostasis model assessment). Mixed model regression analyses were adjusted for sex, age, parental education, sugar and fat intake, and body mass index. RESULTS: Physical fitness was inversely associated with clustered metabolic risk (P<0.001). All coefficients showed a higher clustered metabolic risk with lower physical fitness, except for upper-limb strength (beta = 0.057; P = 0.002) where the opposite association was found. Cardio-respiratory fitness (beta = -0.124; P<0.001) and lower-limb strength (beta = -0.076; P = 0.002) were the most important longitudinal determinants. The effects of cardio-respiratory fitness were even independent of the amount of vigorous-to-moderate activity (beta = -0.059; P = 0.029). Among all the metabolic risk components, blood pressure seemed not well predicted by physical fitness, while waist circumference, blood lipids and insulin resistance all seemed significantly predicted by physical fitness. CONCLUSION: Poor physical fitness in children is associated with the development of cardio-metabolic risk factors. Based on our results, this risk might be modified by improving mainly cardio-respiratory fitness and lower-limb muscular strength.

  • 2130.
    Zaqout, Mahmoud
    et al.
    Department of Public Health, Faculty of Medicine and Health Sciences, Ghent University, De Pintelaan 185, 4K3, Ghent, Belgium.
    Michels, Nathalie
    Department of Public Health, Faculty of Medicine and Health Sciences, Ghent University, De Pintelaan 185, 4K3, Ghent, Belgium.
    Ahrens, Wolfgang
    Leibniz Institute for Prevention Research and Epidemiology BIPS, Bremen, Germany.
    Börnhorst, Claudia
    Leibniz Institute for Prevention Research and Epidemiology BIPS, Bremen, Germany.
    Molnár, Dénes
    Department of Pediatrics, Medical Faculty, University of Pécs, Pécs, Hungary.
    Moreno, Luis A.
    GENUD (Growth, Exercise, Nutrition and Development) Research Group, University of Zaragoza, Zaragoza, Spain.
    Eiben, Gabriele
    Department of Public Health and Community Medicine, Sahlgrenska Academy, University of Gothenburg, Gothenburg, Sweden.
    Siani, Alfonso
    Epidemiology and Population Genetics, Institute of Food Sciences, National Research Council, Avellino, Italy.
    Papoutsou, Stalo
    Research and Education Institute of Child Health, Strovolos, Cyprus.
    Veidebaum, Toomas
    Department of Chronic Diseases, National Institute for Health Development, Tallinn, Estonia.
    De Henauw, Stefaan
    Department of Public Health, Faculty of Medicine and Health Sciences, Ghent University, De Pintelaan 185, 4K3, Ghent, Belgium.
    Associations between exclusive breastfeeding and physical fitness during childhood2018In: European Journal of Nutrition, ISSN 1436-6207, E-ISSN 1436-6215, Vol. 57, no 2, p. 545-555Article in journal (Refereed)
    Abstract [en]

    PURPOSE: Exposure to breastfeeding improves the survival, health, and development of children; therefore, breast milk is recommended as the exclusive nutrient source for feeding term infants during the first 6 months. This cross-sectional study aimed to determine the possible association between exposure to exclusive breastfeeding and physical fitness performance in children and, if so, whether this association is influenced by the breastfeeding duration.

    METHODS: A total of 2853 (52.3 % girls) European children from the IDEFICS study aged 6-11 years with complete data on physical fitness (cardiorespiratory fitness, muscular strength, flexibility, balance, speed) and exclusive breastfeeding duration (never, 1-3, 4-6, 7-12 months) were included in the present study. Multivariate and mixed linear regression models were estimated and adjusted for sex, age, birth weight, diet, physical activity, body mass index, and parental factors (age, body mass index, educational attainment).

    RESULTS: We found a positive association between exclusive breastfeeding and lower-body explosive strength (β = 0.034) as well as flexibility (β = 0.028). We also found a positive association between breastfeeding and balance in boys (β = 0.039), while this association was negative in girls (β = -0.029). To improve lower-body explosive strength, 1-3 months of exclusive breastfeeding were enough; a longer duration did not lead to increasing benefit. In contrast, 4-6 months of breastfeeding were necessary to have any benefit on flexibility or balance, although this became nonsignificant after adjustment for body mass index and physical activity.

    CONCLUSIONS: Exclusive breastfeeding seems a natural way of slightly improving some physical fitness components (mainly lower-body muscle strength) and thus future health.

  • 2131.
    Zare, Zahra
    et al.
    Department of Statistics and Epidemiology, Faculty of Health, Tabriz University of Medical Sciences, Iran.
    Sadeghi-Bazargani, Homayoun
    Road Traffic Injury Research Center, Tabriz University of Medical Sciences, Iran.
    Ranjbar, Fatemeh
    Research Center of Psychiatry and Behavioral sciences, Tabriz University of Medical Sciences, Tabriz, Iran.
    Stark Ekman, Diana
    University of Skövde, School of Health and Education. University of Skövde, Health and Education.
    Farahbakhsh, Mostafa
    Health Services Management Research Center, Tabriz University of Medical Sciences, Tabriz, Iran.
    Maghsoudi, Hemmat
    Department of Surgery, Sina Burn Center, Tabriz University of Medical Sciences, Iran.
    Ekman, Robert
    Department of Architecture and Civil Engineering, Chalmers University of Technology, Gothenburg, Sweden.
    Nasiri, Farideh
    Sociologist at Tabriz University of Medical Sciences, Iran.
    Psychometric Properties of a New Instrument for Assessing Irrational Thoughts in Burn Victims (Scale of Irrational Thoughts After Burn Injuries)2017In: Journal of Burn Care & Research, ISSN 1559-047X, E-ISSN 1559-0488, Vol. 38, no 5, p. e834-e841Article in journal (Refereed)
    Abstract [en]

    The objective of this study was to develop and evaluate a scale for assessing irrational thoughts among burned patients. The present study was mixed (qualitative-methodologic) which was performed in several stages such as investigating similar or related scales, interviewing with patients and psychologists. Content validity was calculated by modified KAPPA basis on relevance and clarity. The reliability of the scale was measured using internal consistency and the test-retest method. To determine the construct validity, exploratory factor analysis approach using maximum likelihood extraction with varimax rotation was conducted. A total of 329 burned patients were recruited from Tehran, Tabriz, and Kermanshah provinces of Iran. Modified kappa scores were 0.80 and 0.91 for relevance and clarity of the items included in scale. The Cronbach alpha for overall scale, subscale 1, and subscale 2 were 0.89, 0.88, and 0.8, respectively. Test-retest reliability was also acceptable (intraclass correlation coefficient = 0.80). The best solution from the maximum likelihood analysis of the 39 items of the scale revealed two factors corresponding to the two subscales with 14 items that subscale 1 (self-acceptance) consisted of 10 statements accounting for 60% of the variance (eigenvalue = 5.04) and subscale 2 (distastefulness and pity) consisted of four statements accounting for 40% of the variance (eigenvalue = 1.53). The scale reflects acceptable levels of validity and reliability in assessing the irrational thoughts among Iranian patients. Moreover, the testing populations of both patients with burned faces and patients with other burned body parts indicates that the scale may also be applicable for patients' burn disfigurements on any part of their bodies.

  • 2132.
    Zare, Zahra
    et al.
    Tabriz University of Medical Sciences, Tabriz, Iran.
    Sadeghi-Bazargani, Homayoun
    Tabriz University of Medical Sciences, Tabriz, Iran.
    Stark Ekman, Diana
    University of Skövde, School of Health and Education. University of Skövde, Health and Education.
    Ranjbar, Fatemeh
    Tabriz University of Medical Sciences, Tabriz, Iran.
    Ekman, Robert
    Chalmers University of Technology, Göteborg, Sweden.
    Farahbakhsh, Mostafa
    Tabriz University of Medical Sciences, Tabriz, Iran.
    Maghsoudi, Hemmat
    Tabriz University of Medical Sciences, Tabriz, Iran.
    Cognitive Distortions as Trauma-Specific Irrational Beliefs Among Burn Patients2019In: Journal of Burn Care & Research, ISSN 1559-047X, E-ISSN 1559-0488, Vol. 40, no 3, p. 361-367Article in journal (Refereed)
    Abstract [en]

    Burn injuries are most certainly stressful events, particularly when permanent disfigurement is a result. This situation can lead to the onset of irrational beliefs which can in turn lead to long-term psychological problems such as depression, anxiety, shame, guilt, posttraumatic stress, etc. The objective of this study is to explore the irrational beliefs among burn patients and its correlates in an Iranian sample. This cross-sectional study included 329 patients who had experienced disfigurement, as result of burn injuries. In order to assess irrational beliefs, a Scale for Irrational Thoughts after Burning was used. To identify correlated variables with irrational beliefs, both bivariate and multivariate analysis methods were conducted. In multivariate linear regression, forward strategy was used for building the model. The results of bivariate analysis showed that the location of the burn on bodies (body parts generally exposed in social environment or parts culturally perceived as sensitive areas of body), marital status, urbanities, age group, geographical areas, etiology of burning, and intent of injury had significant relationships with irrational beliefs (P < .05). Using forward linear regression, gender, marital status, geographical areas, etiology of burning, body burn by location (body parts generally exposed in social environment or parts culturally perceived as sensitive areas of body), and intent of injury had significant correlation with irrational beliefs. The models predicted 15.5% (P < .001) of irrational beliefs. Considering to irrational beliefs and development of facilities for screening is necessary. Moreover, consultation with mental health experts after burn injuries is highly recommended. 

  • 2133.
    Zaytoun, Maria
    University of Skövde, School of Health and Education. mariazaytoun@hotmail.com.
    Sjuksköterskors erfarenheter av att vårda och bemöta äldre med demenssjukdom: En litteraturbaserad studie2018Independent thesis Basic level (degree of Bachelor), 10 credits / 15 HE creditsStudent thesis
    Abstract [en]

    Background: Dementia is a common disease and is among the leading causes of disability amongst elderly people. Dementia disease can lead to personality changes, memory disorders, confusion and communication difficulties, amongst other things. These symptoms demand nurses to adapt their way of nursing and treating to offer the best possible care. Aim: The aim with a literature-based study is to describe nurses’ experiences with nursing and treating elderly with dementia disease. Method: In the following study a total of 10 articles of qualitative nature have been reviewed and analyzed in a structured manner. Result: The following four themes have been identified regarding the studied articles; The caring creates a variety of emotions, the importance of having prerequisites, knowledge about the individual behind the disease and the importance of being able to communicate and interact. Conclusion and clinical implications: Good treatment is a prerequisite for good care. To treat elderly with dementia the right preconditions like, time, a person-centered approach, knowledge about the disease and communication skills are necessary. The result can contribute to an increased understanding of nurses by describing other nurses' actual experiences of how nursing and treatment of elderly with dementia disease can be seen in practice.   

  • 2134.
    Zeijlon, Jessika
    et al.
    University of Skövde, School of Life Sciences.
    Lidestam, Magdalena
    University of Skövde, School of Life Sciences.
    Vad förebygger depression bland äldre: en litteraturstudie2012Independent thesis Basic level (degree of Bachelor), 10 credits / 15 HE creditsStudent thesis
    Abstract [en]

    Late-life depression is a major public health problem which causes emotional suffering among individuals and their relatives, and also leads to increased health care costs. In Sweden the prevalence of late-life depression is approximately 12-15 % among those aged 65 and older. The aim of this literature review was to compile and examine previous research considering late-life depression-preventive factors. Literature searches were made in the databases LibHub, PubMed and Cinahl using the keywords: prevention, depression, depressive symptoms, elderly, old and old people. Twelve scientific articles were selected and analyzed. Five main themes were identified. Theme activity showed conflicting results, dietary supplements were effective in one of two studies and social support was an important factor in preventing depression and counteracts the negative effects of stressful life events and economic stress. Cognitive strategies such as “positive restructuring” and CBT treatment were found to have an effect on depression symptoms. An intervention program including training of nursery care staff had significant effect, especially in nursing homes with a high prevalence of depression. Conclusion: Further literature studies and further deepening of the different themes are needed to draw accurate conclusions. There is a need for more research in this area, larger studies and longer follow-up is needed.

  • 2135.
    Zhang, Hong
    et al.
    University of Skövde, School of Life Sciences.
    Sun, Xiao-Feng
    Department of Biomedicine and Surgery, Faculty of Health Sciences, Linköping University, Linköping, Sweden.
    Synnerstad, Ingrid
    Division of Dermatology, Department of Clinical and Experimental Medicine, Linköping University, Sweden.
    Rosdahl, Inger
    Division of Dermatology, Department of Clinical and Experimental Medicine, Linköping University, Sweden.
    Importance of FAS-1377, FAS-670 and FASL-844 Polymorphisms in Tumor Onset, Progression and Pigment Phenotypes of Swedish Patients With Melanoma: A Case-Control Analysis2007In: The Cancer Journal, ISSN 1528-9117, E-ISSN 1540-336X, Vol. 13, no 4, p. 233-237Article in journal (Refereed)
    Abstract [en]

    PURPOSE: Human skin melanoma at later stages usually has an extremely poor prognosis. It is of importance to search for biologic markers to identify and monitor individuals at risk for melanoma for early diagnosis and to avoid tumor progression. The FAS gene and its natural ligand (FASL) gene initiate the death signal cascade, playing a central role in the apoptotic signaling pathway and tumor growth and metastasis. PATIENTS AND METHODS: In this study, we analyzed polymorphisms in 229 patients with melanoma and 351 age- and gender-matched tumor-free individuals. Genomic DNAs were isolated from mononuclear cells in peripheral vein blood, and the polymorphisms were examined with polymerase chain reaction-restriction fragment length polymorphism techniques. Frequency in distribution of the polymorphisms was compared between the patients with melanoma and the healthy control subjects, and associations with patients' pigment phenotypes, age at diagnosis, and melanoma characteristics were analyzed. RESULTS AND CONCLUSIONS: The FAS-1377, FAS-670, and FASL-844 polymorphisms were not found to be markers of melanoma risk (P > 0.05). In patients with melanoma, frequencies of the FAS-1377, FAS-670, and FASL-844 polymorphisms were different between the patients aged <50 and > or =50 years (P < or = 0.025, P < or = 0.025, and P < or = 0.01). Moreover, the FAS-670 polymorphism correlated with tumor Breslow thickness (P < or = 0.01) and Clark level (P < or = 0.001) and was associated with tumors developing in sun-exposed locations (P < or = 0.001). FAS and FASL were not markers for melanoma risk but might be important in the development and progression of sun-induced melanoma independently of skin type.

  • 2136.
    Zhang, Hong
    et al.
    University of Skövde, School of Life Sciences. University of Skövde, The Systems Biology Research Centre.
    Wang, Da-Wei
    University of Skövde, School of Life Sciences. University of Skövde, The Systems Biology Research Centre. Department of Stomatology, The Third Hospital of Hebei Medical University, Hebei, China.
    Adell, Gunnar
    Department of Oncology, Karolinska University Hospital, Karolinska, Sweden.
    Sun, Xiao-Feng
    Division of Oncology, Department of Clinical and Experimental Medicine, Faculty of Heath Science, Linköping University, Sweden .
    WRAP53 is an independent prognostic factor in rectal cancer- a study of Swedish clinical trial of preoperative radiotherapy in rectal cancer patients2012In: BMC Cancer, ISSN 1471-2407, E-ISSN 1471-2407, Vol. 12, p. 294-Article in journal (Refereed)
    Abstract [en]

    Background: Expression of WRAP53 protein has oncogenic properties and it is up regulated in several types of tumors. Methods: We examined expression of WRAP53 protein in rectal cancers and analyzed its relationship to the response to preoperative radiotherapy and patient survival. The WRAP53 protein was examined by immunohistochemistry in normal mucosa, primary tumors and lymph node metastases from 143 rectal cancer patients participated in a Swedish clinical trial of preoperative radiotherapy. Results: Frequency of WRAP53 protein expression was increased in primary rectal cancer compared to the normal mucosa (p < 0.05). In non-radiotherapy group positive WRAP53 in primary tumors (p = 0.03, RR, 3.73, 95% CI, 1.13-11.89) or metastases (p = 0.01, RR, 4.11, 95% CI, 1.25-13.14), was associated with poor prognosis independently of stages and differentiations. In radiotherapy group, positive WRAP53 in the metastasis correlated with better survival (p = 0.04). An interaction analysis showed that the correlations of WRAP53 with the prognostic significance with and without radiotherapy in the metastasis differed (p = 0.01). In the radiotherapy group, expression of WRAP53 in metastases gave a better outcome (p = 0.02, RR, 0.32, 95% CI, 0.13-0.84), and an interaction analysis showed significance between the two groups (p = 0.01). Conclusion: WRAP53 may be a new biomarker used to predict prognosis and to select suitable patients for preoperative radiotherapy.

  • 2137.
    Ährlund-Richter, Andreas
    University of Skövde, School of Health and Education. Forskargrupp: Tina Dalianis, KI.
    Oral and genital human papillomavirus (HPV) prevalence in young women and men attending a youth clinic in Stockholm, Sweden: A follow up study after the introduction of HPV vaccination2017Independent thesis Basic level (degree of Bachelor), 20 credits / 30 HE creditsStudent thesis
    Abstract [en]

    Background and Aim: In 2010 HPV vaccination was subsidized in Sweden and in 2012 a national vaccination program against HPV16, 18, 6 and 11 was launched for girls ages 10-12 years. In parallel was a catch-up vaccination program for young women. To investigate base line HPV cervical and oral prevalence in non-vaccinated youth two studies were performed at a youth clinic in Stockholm 2008-2011. This project initiated 2013 aimed to follow HPV prevalence in youth since the previous studies, in the same population.  

    Materials and Methods: 117 women, of which 73% were HPV catch-up vaccinated donated 93 cervical samples and 117 oral samples, and 54 unvaccinated men donated 54 oral samples and 47 urinary samples. All samples were tested for 27 HPV types with a PCR based system and the data was compared to that obtained in 2008-2011. The categorical Fishers exact test was used for statistical analysis due to HPV-positive samples being n< 5 for certain types. 

    Results and Conclusion: HPV16 cervical prevalence was significantly lower in the HPV vaccinated women compared to unvaccinated women (7% and 27% respectively, p=0.033) in the 2013 group. For HPV18 and HPV6 there was a significantly lower prevalence in the 2013 vaccinated group compared to the 2008-2010 unvaccinated group (1.5% vs. 10% respectively, p=0.021 and 1.5% vs. 8% respectively, p=0.048). Overall oral HPV prevalence for both genders, was lower in the 2013 group compared to that of 2009-2011, (2.3% and 9.1% respectively, p=0.005). Male urinary prevalence was low (6%) and not efficient to follow changes in specific HPV types. The data indicate that HPV catch-up vaccination was gradually exhibiting an effect, with significant decrease of cervical HPV16 prevalence.

  • 2138.
    Åberg, Cecilia
    University of Skövde, School of Health and Education. University of Skövde, Health and Education.
    Att lära i den verksamhetsförlagda delen av utbildningen2015In: Reflektion i lärande och vård - en utmaning för sjuksköterskan / [ed] Mia Berglund, Margaretha Ekebergh, Lund: Studentlitteratur AB, 2015, 1, p. 145-162Chapter in book (Refereed)
  • 2139.
    Åberg, Malin
    et al.
    University of Skövde, School of Health and Education.
    Joelsson, Josefine
    University of Skövde, School of Health and Education.
    Kvinnliga patienters upplevelse under pågående behandling av bröstcancer.: En kvalitativ studie av bloggar2016Independent thesis Basic level (university diploma), 10 credits / 15 HE creditsStudent thesis
  • 2140.
    Ådemark, Ulrika
    et al.
    University of Skövde, School of Health and Education.
    Persson, Lisa
    University of Skövde, School of Health and Education.
    BVC-sjuksköterskors erfarenheter av att möta föräldrar när barnet har övervikt eller fetma2014Independent thesis Advanced level (degree of Master (One Year)), 10 credits / 15 HE creditsStudent thesis
    Abstract [en]

    Background: A Child health care nurse has a unique opportunity to identify children at risk of becoming overweight or obese. During consultation with parents, one of the most important tasks of nurses is to effectively communicate ways to benefit the child's health. Overweight and obesity are well known risk factors for chronic health conditions and decreased general health later in life, thus making the implementation of health promotion and preventative measures early in life vital.

    Aim: To evaluate the experiences of Child health care nurses after consultation with parents of overweight or obese children.

    Method: Interviews with nine Child health care nurses working with children's health were performed.An inductive approach was applied where data was analyzed with qualitative content analysis.

    Result: Four main categories emerged from the analysis; Family situation affects the consultation, Giving necessary guidance, Pedagogic strategy and Problems in communication, and nine subcategories.

    Conclusion: This study reveals that Child health care nurses identify trust as a major factor in consultations with parents. Trust is important for the nurse to be able to support and guide parents concerning weight issues of their children. The nurse must keep the family situation and surrounding factors influencing the meeting in mind.

  • 2141. Ådin, Hanna
    et al.
    Ekstrand, Maria
    Hammarlund, Kina
    University of Skövde, School of Life Sciences.
    Oskönt, krångligt, plastigt2009In: Insikt, ISSN 1104-0912, no 4, p. 8-9Article in journal (Other (popular science, discussion, etc.))
  • 2142.
    Åman Svensson, Mattias
    University of Skövde, School of Health and Education. mattias.aman.svensson@gmail.com.
    Att behandla depression hos äldre: en global utmaning2018Independent thesis Basic level (degree of Bachelor), 10 credits / 15 HE creditsStudent thesis
    Abstract [en]

    Background: The older population makes up the largest group of people struck by mental depression. Meanwhile it is also the most rapidly increasing population group suffering from depression. There is a lack of research in this field and there are indications that older people do not respond to treatment in the same way as the younger population. The aim of this literature review is to examine methods of treatment for depression in the elderly population.Method: A systematic literature review with thematic content analysis of quantitative data.Results: Fifteen articles were included. The analysis resulted in four themes: Physical activity, Therapy, Social interaction, Medical treatment. Conclusion: There are indications of treatments with good effect, but it is difficult to identify possible clinical implications due to heterogeneity within the study population. More studies in the field focusing on subgroups are needed.

  • 2143.
    Öberg, Isabella
    University of Skövde, School of Health and Education.
    Copingstrategier för sjuksköterskor i mötet med döden inom vården: En kvalitativ litteraturstudie2018Independent thesis Basic level (degree of Bachelor), 10 credits / 15 HE creditsStudent thesis
  • 2144.
    Öhlin, Linnéa
    et al.
    University of Skövde, School of Health and Education.
    Kjellén, Malin
    University of Skövde, School of Health and Education.
    ”DET HÄR ÄR JAG FÖR ALLTID”: En kvalitativ studie baserad på bloggar skrivna av människor som lever med hiv2018Independent thesis Basic level (degree of Bachelor), 10 credits / 15 HE creditsStudent thesis
    Abstract [en]

    Background: The human immunodeficiency virus (HIV) is a cause of chronic disease discovered in America in the 1980s. People living with HIV have since the discovery of the disease been exposed to discrimination, stigmatization and exclusion. Today effective treatment enables people with HIV to live a life without reduced lifespan. Purpose: The aim of the study is to describe people's experience of living with HIV in Sweden. Method: Narrative method based on qualitative data in form of blogs written by people living with HIV. Google database from google LLC was searched for relevant material. Result: The notification of HIV causes feelings of shock, fear and anxiety of death. Concurrent with the shocking message, a considerable need to converse occurs. However, many people also experience a fear of rejection when they tell others that they are HIV positive. This fear also have a negative impact on their sex life, since many of the them prefer to refrain from sexual relations rather than telling about the virus. Despite these difficulties, people living with HIV create strategies that make life manageable, and express a gratitude for lessons learned since exposure. Conclusion: The toughest challenge for people living with HIV is to deal with the prejudices and stigmatization by people in their surrounding.

  • 2145.
    Öhlén, Joakim
    et al.
    Institute of Health Care Sciences, Sahlgrenska Academy at the University of Gothenburg, Sweden.
    Furåker, Carina
    Institute of Health Care Sciences, Sahlgrenska Academy at the University of Gothenburg, Sweden.
    Jakobsson, Eva
    Institute of Health Care Sciences, Sahlgrenska Academy at the University of Gothenburg, Sweden.
    Bergh, Ingrid
    University of Skövde, School of Life Sciences.
    Hermansson, Evelyn
    Institute of Health Care Sciences, Sahlgrenska Academy at the University of Gothenburg, Sweden.
    Impact of the Bologna process in Bachelor nursing programmes: The Swedish case2011In: Nurse Education Today, ISSN 0260-6917, E-ISSN 1532-2793, Vol. 31, no 2, p. 122-128Article in journal (Refereed)
    Abstract [en]

    The higher education reform in Europe known as the “Bologna Process” implies further harmonisation and integration of nursing programmes into the higher education system. This study explores this process in Sweden, where the development of nursing education into an undergraduate programme started in 1977. The aim of this study was to analyse characteristics of the major subject and its relationship to other subject areas, such as medical sciences and social sciences, in Bachelor level nursing programmes in Sweden following initial implementation of the Bologna process. A constructivist approach and descriptive content analysis were employed to analyse the 2008 nursing curricula and syllabi of 27 undergraduate programmes at 26 Swedish universities and university colleges. The results revealed variation in terms and concepts used for the major subject as well as its scientific foundation, demarcation between the major subject and other subjects included in the study programmes and its relationship to the profession. These variations are linked to the variety of research orientations under debate in the Scandinavian countries: Nursing Science and Caring Science; representing different knowledge domains, focus, challenges and visions for the discipline. Potential implications of basing curricula on a major subject other than Nursing Science in a Bachelor level nursing programme are highlighted.

  • 2146.
    Östergren-Lundén, Gunnel
    et al.
    Wallenberg Laboratory for Cardiovascular Research, The Sahlgrenska Academy at Göteborg University, Göteborg, Sweden.
    Olivas, Raquel G.
    Departamento de Biologı́a Celular, Universitat de Barcelona, Barcelona, Spain.
    Eftekhari, Pierre
    UPR9021 C.N.R.S., Immunologie et Chimie Thérapeutiques, I.B.M.C., Strasbourg, France.
    Krettek, Alexandra
    Wallenberg Laboratory for Cardiovascular Research, The Sahlgrenska Academy at Göteborg University, Göteborg, Sweden.
    Sanjuan, Xavier
    Departamento de Biologı́a Celular, Universitat de Barcelona, Barcelona, Spain.
    Fager, Gunnar
    Wallenberg Laboratory for Cardiovascular Research, The Sahlgrenska Academy at Göteborg University, Göteborg, Sweden.
    Vilaró, Senén
    Departamento de Biologı́a Celular, Universitat de Barcelona, Barcelona, Spain.
    Lustig, Florentyna
    Wallenberg Laboratory for Cardiovascular Research, The Sahlgrenska Academy at Göteborg University, Göteborg, Sweden.
    Hoebeke, Johan
    UPR9021 C.N.R.S., Immunologie et Chimie Thérapeutiques, I.B.M.C., Strasbourg, France.
    Characterisation and application of antibodies specific for the long platelet-derived growth factor A and B chains2004In: International Journal of Biochemistry and Cell Biology, ISSN 1357-2725, E-ISSN 1878-5875, Vol. 36, no 11, p. 2226-2241Article in journal (Refereed)
    Abstract [en]

    The platelet-derived growth factor (PDGF) family comprises important mitogens for mesenchymal cells. The active dimeric form of PDGF consists of four structurally related A, B, C, and D chains. All PDGF-variants bind to PDGF-receptors. The A and B chains occur with and without basic C-terminal amino acid extensions as long (A(L) and B(L)) and short (A(S) and B(S)) isoforms. PDGF-A and -B form homo- or heterodimers. The biological relevance of short and long isoforms is unknown, although it may relate to different affinities for glycosaminoglycans of the cell glycocalix and intercellular matrix. Commercially available anti-PDGF-A and anti-PDGF-B antibodies cannot discriminate between the short and the long isoforms. Thus, to investigate the function of the long and short isoforms, we raised antibodies specific for the long A and B chain isoforms. The antibodies were affinity-purified and their properties analysed by surface plasmon resonance. Inhibition studies with different PDGF homodimers and dot-blot studies proved their high specificity for the respective isoforms. Both antibodies recognised the target PDGF homodimers complexed to the glycocalix of human arterial smooth muscle cells and human monocyte-derived macrophages. By using these specific antibodies, we were able to confirm at the protein level the synthesis of PDGF-A and -B during differentiation of human monocyte-derived macrophages and to demonstrate the presence of the PDGF-A(L) and PDGF-B(L) isoforms in human arterial tissue.

  • 2147.
    Österlind, Jane
    et al.
    Ersta Sköndal University College and Ersta Hospital, Palliative Research Centre, Stockholm, Sweden / Ersta Sköndal University College, Department of Health Care Sciences, Stockholm, Sweden.
    Prahl, Charlotte
    Ersta Sköndal University College and Ersta Hospital, Palliative Research Centre, Stockholm, Sweden / Ersta Sköndal University College, Department of Health Care Sciences, Stockholm, Sweden.
    Westin, Lars
    University of Skövde, School of Health and Education. University of Skövde, Health and Education.
    Strang, Susann
    Sahlgrenska Academy, University of Gothenburg, Institute of Health and Care Sciences, Sweden / Angered Hospital, Sweden.
    Bergh, Ingrid
    University of Skövde, School of Health and Education. University of Skövde, Health and Education.
    Henoch, Ingela
    Ersta Sköndal University College and Ersta Hospital, Palliative Research Centre, Stockholm, Sweden / Angered Hospital, Sweden / University of Gothenburg Centre for Person-Centred Care (GPCC), Sahlgrenska Academy, University of Gothenburg, Sweden.
    Hammarlund, Kina
    University of Skövde, School of Health and Education. University of Skövde, Health and Education.
    Ek, Kristina
    University of Skövde, School of Health and Education. University of Skövde, Health and Education.
    Nursing students' perceptions of caring for dying people, after one year in nursing school2016In: Nurse Education Today, ISSN 0260-6917, E-ISSN 1532-2793, Vol. 41, p. 12-16Article in journal (Refereed)
    Abstract [en]

    Aim: To describe Swedish nursing students' perceptions of caring for dying people after the first year of a three year in a nursing programme at three university nursing schools in Sweden. Methods: Interviews (n = 17) were undertaken with nursing students at the end of their first year. A phenomenographic approach was used to design and structure the analysis of the nursing students' perceptions. Results: The analysis resulted in five categories: 1) from abstract to reality, 2) from scary to natural, 3) increased knowledge can give bad conscience, 4) time limits versus fear of end-of-life conversations, and 5) meeting with relatives. Conclusion: Nursing students need to be prepared both theoretically and within practice to encounter death and dying and to care for dying persons. By combining their theoretical knowledge of dying and death with their own encounters of death and dying people in practice, the students can be supported to develop an understanding of dying and death as a natural part of life rather than something frightening. 

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