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  • 201.
    Jonsson, Malin K. B.
    et al.
    Genome Institute of Singapore, Genome, Singapore.
    van Veen, Toon A. B.
    Department of Medical Physiology, Division of Heart & Lungs, UMC Utrecht, Utrecht, Netherlands.
    Synnergren, Jane
    Högskolan i Skövde, Institutionen för naturvetenskap. Högskolan i Skövde, Institutionen för biovetenskap.
    Becker, Bruno
    Department of Psychiatry and Neurochemistry, Sahlgrenska University Hospital, Mölndal, Sweden.
    Towards Creating the Perfect In Vitro Cell Model2016Ingår i: Stem Cells International, ISSN 1687-9678, Vol. 2016, artikel-id 3459730Artikel i tidskrift (Refereegranskat)
  • 202.
    Jonsson, Tomas
    Högskolan i Skövde, Institutionen för biovetenskap. Högskolan i Skövde, Forskningscentrum för Systembiologi. Department of Ecology, Swedish University of Agricultural Sciences, Uppsala, Sweden.
    Conditions for Eltonian Pyramids in Lotka-Volterra Food Chains2017Ingår i: Scientific Reports, ISSN 2045-2322, E-ISSN 2045-2322, Vol. 7, artikel-id 10912Artikel i tidskrift (Refereegranskat)
    Abstract [en]

    In ecological communities consumers (excluding parasites and parasitoids) are in general larger and less numerous than their resource. This results in a well-known observation known as 'Eltonian pyramids' or the ` pyramid of numbers', and metabolic arguments suggest that this pattern is independent of the number of trophic levels in a system. At the same time, Lotka-Volterra (LV) consumer-resource models are a frequently used tool to study many questions in community ecology, but their capacity to produce Eltonian pyramids has not been formally analysed. Here, I address this knowledge gap by investigating if and when LV food chain models give rise to Eltonian pyramids. I show that Eltonian pyramids are difficult to reproduce without density-dependent mortality in the consumers, unless biologically plausible relationships between mortality rate and interaction strength are taken into account.

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  • 203.
    Jonsson, Tomas
    Högskolan i Skövde, Institutionen för biovetenskap. Högskolan i Skövde, Forskningscentrum för Systembiologi. Department of Ecology, Swedish University of Agricultural Sciences, Uppsala, Sweden.
    Metabolic theory predicts animal self-thinning2017Ingår i: Journal of Animal Ecology, ISSN 0021-8790, E-ISSN 1365-2656, Vol. 86, nr 3, s. 645-653Artikel i tidskrift (Refereegranskat)
    Abstract [en]
    1. The metabolic theory of ecology (MTE) predicts observed patterns in ecology based on metabolic rates of individuals. The theory is influential but also criticized for a lack of firm empirical evidence confirming MTE's quantitative predictions of processes, e.g. outcome of competition, at population or community level.
    2. Self-thinning is a well-known population level phenomenon among plants, but a much less studied phenomenon in animal populations and no consensus exists on what a universal thinning slope for animal populations might be, or if it exists.
    3. The goal of this study was to use animal self-thinning as a tool to test population-level predictions from MTE, by analysing (i) if self-thinning can be induced in populations of house crickets (Acheta domesticus) and (ii) if the resulting thinning trajectories can be predicted from metabolic theory, using estimates of the species-specific metabolic rate of A. domesticus.
    4. I performed a laboratory study where the growth of A. domesticus was followed, from hatching until emergence as adults, in 71 cohorts of five different starting densities.
    5. Ninety-six per cent of all cohorts in the three highest starting densities showed evidence of self-thinning, with estimated thinning slopes in general being remarkably close to that expected under metabolic constraints: A cross-sectional analysis of all data showing evidence of self-thinning produced an ordinary least square (OLS) slope of −1·11, exactly that predicted from specific metabolic allometry of A. domesticus. This result is furthermore supported by longitudinal analyses, allowing for independent responses within cohorts, producing a mean OLS slope across cohorts of −1·13 and a fixed effect linear mixed effects models slope of −1·09. Sensitivity analysis showed that these results are robust to how the criterion for on-going self-thinning was defined. Finally, also as predicted by metabolic theory, temperature had a negative effect on the thinning intercept, producing an estimate of the activation energy identical to that suggested by MTE.
    6. This study demonstrates a direct link between the metabolic rate of individuals and a population-level ecological process and as such provides strong support for research that aims to integrate body mass, via its effect on metabolism, consumption and competition, into models of populations and communities.
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  • 204.
    Jonsson, Tomas
    et al.
    Högskolan i Skövde, Institutionen för biovetenskap. Högskolan i Skövde, Forskningscentrum för Systembiologi. Department of Ecology, Swedish University of Agricultural Sciences, Uppsala, Sweden.
    Berg, Sofia
    Högskolan i Skövde, Institutionen för biovetenskap. Högskolan i Skövde, Forskningscentrum för Systembiologi. Department of Physics, Chemistry and Biology, Division of Theoretical Biology, Linköping University, Linköping, Sweden.
    Emmerson, Mark
    School of Biological Sciences, Queen's University Belfast, Belfast, UK.
    Pimenov, Alexander
    Environmental Research Institute, University College Cork, Lee Road, Cork, Ireland / Weierstrass Institute, Berlin, Germany.
    The context dependency of species keystone status during food web disassembly2015Ingår i: Food Webs, ISSN 2352-2496, Vol. 5, s. 1-10Artikel i tidskrift (Refereegranskat)
  • 205.
    Jonsson, Tomas
    et al.
    Högskolan i Skövde, Institutionen för biovetenskap. Högskolan i Skövde, Forskningscentrum för Systembiologi. Dept of Ecology, Swedish Univ. of Agricultural Sciences, Uppsala, Sweden.
    Berg, Sofia
    Högskolan i Skövde, Institutionen för biovetenskap. Högskolan i Skövde, Forskningscentrum för Systembiologi. Dept of Physics, Chemistry and Biology, Div. of Theoretical Biology, Linköping Univ., Linköping, Sweden.
    Pimenov, Alexander
    Environmental Res. Inst., Univ. College Cork, Cork, Ireland / Weierstrass Inst., Berlin, Germany.
    Palmer, Catherine
    Environmental Res. Inst., Univ. College Cork, Cork, Ireland.
    Emmerson, Mark
    School of Biological Sciences, Queen's Univ. Belfast, Belfast, United Kingdom.
    The reliability of R50 as a measure of vulnerability of food webs to sequential species deletions2015Ingår i: Oikos, ISSN 0030-1299, E-ISSN 1600-0706, Vol. 124, nr 4, s. 446-457Artikel i tidskrift (Refereegranskat)
  • 206.
    Jonsson, Tomas
    et al.
    Högskolan i Skövde, Institutionen för biovetenskap. Högskolan i Skövde, Forskningsmiljön Systembiologi. Department of ecology, Swedish university of agricultural sciences, Sweden / Department of physics, chemistry and biology, Division of theoretical biology, Linköping university, Sweden.
    Berg, Sofia
    Högskolan i Skövde, Institutionen för biovetenskap. Högskolan i Skövde, Forskningsmiljön Systembiologi. Department of physics, chemistry and biology, Division of theoretical biology, Linköping university, Sweden.
    Säterberg, Torbjörn
    Department of physics, chemistry and biology, Division of theoretical biology, Linköping university, Sweden.
    Hauzy, Céline
    Department of physics, chemistry and biology, Division of theoretical biology, Linköping university, Sweden / UPMC, Ecologie et evolution, France INRA, USC 2031 Ecologie des populations et communautés, France.
    Ebenman, Bo
    Department of physics, chemistry and biology, Division of theoretical biology, Linköping university, Sweden.
    Rare but Important: Perturbations to Uncommon Species Can Have a Large Impact on the Structure of Ecological Communities2017Ingår i: Adaptive Food Webs: Stability and Transitions of Real and Model Ecosystems / [ed] John C. Moore, Peter C. de Ruiter, Kevin S. McCann, Volkmar Wolters, Cambridge University Press, 2017, s. 324-341Kapitel i bok, del av antologi (Refereegranskat)
  • 207.
    Jonsson, Tomas
    et al.
    Högskolan i Skövde, Institutionen för biovetenskap. Högskolan i Skövde, Forskningscentrum för Systembiologi. Department of Ecology, Swedish University of Agricultural Sciences, Uppsala, Sweden.
    Kaartinen, Riikka
    Department of Ecology, Swedish University of Agricultural Sciences, Uppsala, Sweden.
    Jonsson, Mattias
    Department of Ecology, Swedish University of Agricultural Sciences, Uppsala, Sweden.
    Bommarco, Riccardo
    Department of Ecology, Swedish University of Agricultural Sciences, Uppsala, Sweden.
    Predictive power of food web models based on body size decreases with trophic complexity2018Ingår i: Ecology Letters, ISSN 1461-023X, E-ISSN 1461-0248, Vol. 21, nr 5, s. 702-712Artikel i tidskrift (Refereegranskat)
    Abstract [en]

    Food web models parameterised using body size show promise to predict trophic interaction strengths (IS) and abundance dynamics. However, this remains to be rigorously tested in food webs beyond simple trophic modules, where indirect and intraguild interactions could be important and driven by traits other than body size. We systematically varied predator body size, guild composition and richness in microcosm insect webs and compared experimental outcomes with predictions of IS from models with allometrically scaled parameters. Body size was a strong predictor of IS in simple modules (r(2)=0.92), but with increasing complexity the predictive power decreased, with model IS being consistently overestimated. We quantify the strength of observed trophic interaction modifications, partition this into density-mediated vs. behaviour-mediated indirect effects and show that model shortcomings in predicting IS is related to the size of behaviour-mediated effects. Our findings encourage development of dynamical food web models explicitly including and exploring indirect mechanisms.

  • 208.
    Jonsson, Tomas
    et al.
    Högskolan i Skövde, Institutionen för biovetenskap. Högskolan i Skövde, Forskningscentrum för Systembiologi. Department of Ecology, Swedish University of Agricultural Sciences, Uppsala, Sweden.
    Setzer, Malin
    Högskolan i Skövde, Institutionen för biovetenskap. Högskolan i Skövde, Forskningscentrum för Systembiologi.
    A freshwater predator hit twice by effects of warming across trophic levels2015Ingår i: Nature Communications, ISSN 2041-1723, E-ISSN 2041-1723, Vol. 6, artikel-id 5992Artikel i tidskrift (Refereegranskat)
  • 209.
    Junnarkar, Manisha
    et al.
    Microbial Diversity Research Centre, Dr D Y Patil Biotechnology and Bioinformatics Institute, Dr D Y Patil Vidyapeeth, Tathawade, Maharashtra, India.
    Pawar, Sarika
    Microbial Diversity Research Centre, Dr D Y Patil Biotechnology and Bioinformatics Institute, Dr D Y Patil Vidyapeeth, Tathawade, Maharashtra, India.
    Gaikwad, Swapnil
    Microbial Diversity Research Centre, Dr D Y Patil Biotechnology and Bioinformatics Institute, Dr D Y Patil Vidyapeeth, Tathawade, Maharashtra, India.
    Mandal, Abul
    Högskolan i Skövde, Institutionen för biovetenskap. Högskolan i Skövde, Forskningsmiljön Systembiologi.
    Jass, Jana
    The Life Science Centre, School of Science and Technology, Örebro University, Örebro, Sweden.
    Nawani, Neelu
    Microbial Diversity Research Centre, Dr D Y Patil Biotechnology and Bioinformatics Institute, Dr D Y Patil Vidyapeeth, Tathawade, Maharashtra, India.
    Probiotic potential of lactic acid bacteria from fresh vegetables: Application in food preservation2019Ingår i: Indian Journal of Experimental Biology, ISSN 0019-5189, E-ISSN 0975-1009, Vol. 57, s. 825-838Artikel i tidskrift (Refereegranskat)
    Abstract [en]

    Fresh vegetables are potential source of lactic acid bacteria (LAB). In the present study, LAB were isolated from the fresh vegetables from Pune region. Total 266 LAB were isolated from the edible parts of fresh vegetables viz. cauliflower, gherkins, cluster beans, fenugreek, cow pea, bitter gourd, french beans, tomato, ridged gourd, cucumber and bottle gourd. On phenotypic and molecular characterization predominant genera obtained were Lactobacillus, Enterococcus and Weissella. Twenty one isolates exhibited tolerance to bile salt, acidic pH and pancreatin. Cellular extracts of several isolates with ability to survive in artificial intestinal condition additionally showed antioxidant potential and cell free supernatants xhibited antibacterial potential against selected plant and human pathogens. Bacteriocin and bacteriocin like substances (BLS) substances secreted by these isolates can be used for food preservation.

  • 210.
    Junnarkara, Manisha V.
    et al.
    Dr. D. Y. Patil Biotechnology and Bioinformatics Institute, Dr. D. Y. Patil Vidyapeeth, Pune, India.
    Thakarea, Prasad M.
    Dr. D. Y. Patil Biotechnology and Bioinformatics Institute, Dr. D. Y. Patil Vidyapeeth, Pune, India.
    Yewalea, Priti P.
    Dr. D. Y. Patil Biotechnology and Bioinformatics Institute, Dr. D. Y. Patil Vidyapeeth, Pune, India.
    Rahman, Aminur
    Högskolan i Skövde, Institutionen för biovetenskap. Högskolan i Skövde, Forskningscentrum för Systembiologi.
    Jass, Jana
    Örebro University, Sweden.
    Mandal, Abul
    Högskolan i Skövde, Institutionen för biovetenskap. Högskolan i Skövde, Forskningscentrum för Systembiologi.
    Nawani, Neelu N.
    Dr. D. Y. Patil Biotechnology and Bioinformatics Institute, Dr. D. Y. Patil Vidyapeeth, Pune, India.
    Evaluation of Probiotic Potential of Lactic Acid Bacteria Isolated from Different Sources in Western India2018Ingår i: Food biotechnology, ISSN 0890-5436, E-ISSN 1532-4249, Vol. 32, nr 2, s. 112-129Artikel i tidskrift (Refereegranskat)
    Abstract [en]

    Lactic acid bacteria isolated from unconventional sources are often attractive targets in the quest for obtaining better probiotics. In the present study, 16 members of the genus Lactobacillus, isolated from 3 different sources in western India, viz., plants, fermented foods and beverages, and human feces, were evaluated for their probiotic and bioactive properties. The isolates were closely related to Lactobacillus fermentum, Lactobacillus pentosus, and mainly Lactobacillus plantarum. The isolates were tolerant to bile salt, acidic pH and pancreatin, although pancreatin tolerance was generally low. Cellular extracts of several isolates displayed antioxidant activity, while cell-free supernatants displayed antibacterial activity against human pathogens. Antioxidant activity of Lactobacilli of human origin was higher than those from vegetables or fermented foods and beverages. L. plantarum AG40V prevented spoilage of fresh-cut fruits, vegetables and sprouted mung-beans. Lactobacilli from all sources displayed equal probiotic potential and those of human origin displayed superior antioxidant activity over others.

  • 211.
    Jurcevic, Sanja
    Högskolan i Skövde, Institutionen för biovetenskap. Högskolan i Skövde, Forskningscentrum för Systembiologi. Örebro universitet, Institutionen för hälsovetenskap och medicin.
    MicroRNA expression profiling in endometrial adenocarcinoma2015Doktorsavhandling, sammanläggning (Övrigt vetenskapligt)
  • 212.
    Jurcevic, Sanja
    et al.
    Högskolan i Skövde, Institutionen för biovetenskap. Högskolan i Skövde, Forskningscentrum för Systembiologi.
    Klinga-Levan, Karin
    Högskolan i Skövde, Institutionen för biovetenskap. Högskolan i Skövde, Forskningscentrum för Systembiologi.
    Olsson, Björn
    Högskolan i Skövde, Institutionen för biovetenskap. Högskolan i Skövde, Forskningscentrum för Systembiologi.
    Ejeskär, Katarina
    Högskolan i Skövde, Institutionen för biovetenskap. Högskolan i Skövde, Forskningscentrum för Systembiologi.
    Verification of microRNA expression in human endometrial adenocarcinoma2016Ingår i: BMC Cancer, ISSN 1471-2407, E-ISSN 1471-2407, Vol. 16, nr 1, artikel-id 261Artikel i tidskrift (Refereegranskat)
  • 213.
    Jurcevic, Sanja
    et al.
    Högskolan i Skövde, Institutionen för biovetenskap. Högskolan i Skövde, Forskningscentrum för Systembiologi.
    Olsson, Björn
    Högskolan i Skövde, Forskningscentrum för Systembiologi. Högskolan i Skövde, Institutionen för biovetenskap.
    Klinga-Levan, Karin
    Högskolan i Skövde, Forskningscentrum för Systembiologi. Högskolan i Skövde, Institutionen för biovetenskap.
    MicroRNA expression in human endometrial adenocarcinoma2014Ingår i: Cancer Cell International, ISSN 1475-2867, E-ISSN 1475-2867, Vol. 14, nr 1, artikel-id 88Artikel i tidskrift (Refereegranskat)
    Abstract [en]

    BACKGROUND: MicroRNAs are small non-coding RNAs that play crucial roles in the pathogenesis of different cancer types. The aim of this study was to identify miRNAs that are differentially expressed in endometrial adenocarcinoma compared to healthy endometrium. These miRNAs can potentially be used to develop a panel for classification and prognosis in order to better predict the progression of the disease and facilitate the choice of treatment strategy.

    METHODS: Formalin fixed paraffin embedded endometrial tissue samples were collected from the Örebro university hospital. QPCR was used to quantify the expression levels of 742 miRNAs in 30 malignant and 20 normal endometrium samples. After normalization of the qPCR data, miRNAs differing significantly in expression between normal and cancer samples were identified, and hierarchical clustering analysis was used to identify groups of miRNAs with coordinated expression profiles.

    RESULTS: In comparisons between endometrial adenocarcinoma and normal endometrium samples 138 miRNAs were found to be significantly differentially expressed (p < 0.001) among which 112 miRNAs have not been previous reported for endometrial adenocarcinoma.

    CONCLUSION: Our study shows that several miRNAs are differentially expressed in endometrial adenocarcinoma. These identified miRNA hold great potential as target for classification and prognosis of this disease. Further analysis of the differentially expressed miRNA and their target genes will help to derive new biomarkers that can be used for classification and prognosis of endometrial adenocarcinoma.

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  • 214.
    Järlström, Toni
    Högskolan i Skövde, Institutionen för biovetenskap.
    Neural effects of compassion training2018Självständigt arbete på grundnivå (kandidatexamen), 15 poäng / 22,5 hpStudentuppsats (Examensarbete)
    Abstract [en]

    Compassion is potentially an effective emotion-regulation strategy to face the suffering of self and others. The aim of this paper is to provide an evolutionary understanding of compassion and compassion training (CT) by examining the psychological, neural and behavioral effects of loving-kindness meditation and compassion meditation. The author presents various definitions of compassion and examines the physiological and neural processes behind it. Compassion seems to have evolutionary roots but can be limited due to inherited blocks and fears. Compassion is however trainable and can potentially bypass certain evolutionary-based biases. CT results in various significant psychological effects, most notably positive affect, increased (self) compassion, and mindfulness. Evidence is however inconsistent, especially in relation to active controls. Neural effects are significant yet inconsistent across different experimental conditions. CT without a concurrent task activates (1) the right somatosensory cortices (2) the parieto-occipital sulcus, and (3) the right anterior insula. In relation to the socio-affective video task, CT activates medial orbitofrontal cortex, ventral striatum/nucleus accumbens, putamen, and anterior parts of anterior cingulate cortex; regions related to positive affect, motivational reward and affiliation. These findings converge with the reviewed psychological literature. CT also results in increased altruistic and compassionate behavior towards others, even when it’s costly to the self and under no-reciprocity conditions. Behavioral effects are mostly demonstrated in game-settings against active controls but also in one real-life situation. Together, the results suggest that CT is beneficial to individuals as well as inter-group relationships. 

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  • 215.
    Kabir, Ahmad H.
    et al.
    Plant and Crop Physiology Laboratory, Department of Botany, University of Rajshahi, Rajshahi, Bangladesh.
    Hossain, Mohammad M.
    Plant and Crop Physiology Laboratory, Department of Botany, University of Rajshahi, Rajshahi, Bangladesh.
    Khatun, Most A.
    Plant and Crop Physiology Laboratory, Department of Botany, University of Rajshahi, Rajshahi, Bangladesh.
    Mandal, Abul
    Högskolan i Skövde, Institutionen för biovetenskap. Högskolan i Skövde, Forskningscentrum för Systembiologi.
    Haider, Syed A.
    Plant and Crop Physiology Laboratory, Department of Botany, University of Rajshahi, Rajshahi, Bangladesh.
    Role of Silicon Counteracting Cadmium Toxicity in Alfalfa (Medicago sativa L.)2016Ingår i: Frontiers in Plant Science, ISSN 1664-462X, E-ISSN 1664-462X, Vol. 7, artikel-id 1117Artikel i tidskrift (Refereegranskat)
    Abstract [en]

    Cadmium (Cd) is one of the most phytotoxic elements causing an agricultural problem and human health hazards. This work investigates whether and how silicon (Si) ameliorates Cd toxicity in Alfalfa. The addition of Si in Cd-stressed plants caused significant improvement in morpho-physiological features as well as total protein and membrane stability, indicating that Si does have critical roles in Cd detoxification in Alfalfa. Furthermore, Si supplementation in Cd stressed plants showed a significant decrease in Cd and Fe concentrations in both roots and shoots compared with Cd-stressed plants, revealing that Si-mediated tolerance to Cd stress is associated with Cd inhibition in Alfalfa. Results also showed no significant changes in the  expression of two metal chelators [MsPCS1 (phytochelatin synthase) and MsMT2  (metallothionein)] and PC (phytochelatin) accumulation, indicating that there may be no metal sequestration or change in metal sequestration following Si application under Cd stress in  Alfalfa. We further performed a targeted study on the effect of Si on Fe uptake mechanisms. We observed the consistent reduction in Fe reductase activity, expression of Fe-related genes [MsIRT1 (Fe transporter), MsNramp1 (metal transporter) and OsFRO1 (ferric chelate reductase] and Fe chelators (citrate and malate) by Si application to Cd stress in roots of Alfalfa. These results support that limiting Fe uptake through the down-regulation of Fe acquisition mechanisms confers Si-mediated alleviation of Cd toxicity in Alfalfa. Finally, an increase of catalase (CAT), ascorbate peroxidase (APX) and superoxide dismutase (SOD) activities along with elevated methionine and proline subjected to Si application might play roles, at least in part, to reduce H2O2 and to provide antioxidant defense against Cd stress in Alfalfa. The study shows evidence of the effect of Si on alleviating Cd toxicity in Alfalfa and can be further extended for phytoremediation of Cd toxicity in plants.

  • 216.
    Kader, Shoxan
    Högskolan i Skövde, Institutionen för biovetenskap.
    Modulation of nlrp3 inflammasome by sp110: Regulation and inhibition of NLRP3 inflammasome in Sp110 deficient THP-1 cells2016Självständigt arbete på avancerad nivå (magisterexamen), 20 poäng / 30 hpStudentuppsats (Examensarbete)
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    Shoxan Kader
  • 217.
    Kaffash Hoshiar, Aida
    Högskolan i Skövde, Institutionen för biovetenskap.
    Developing a zebrafish model system for thrombocyte research2017Självständigt arbete på avancerad nivå (masterexamen), 40 poäng / 60 hpStudentuppsats (Examensarbete)
    Publikationen är tillgänglig i fulltext från 2021-01-01 00:00
  • 218.
    Kajonius, Petri J.
    Högskolan i Skövde, Institutionen för biovetenskap. Högskolan i Skövde, Forskningscentrum för Systembiologi. Department of Psychology, University of Gothenburg, Sweden / Department of Behavioral Sciences, University West, Trollhättan, Sweden.
    The Future of Personalized Care: Scientific, Measurement, and Practical Advancements in Personality and Brain Disorders2019Ingår i: Personality and Brain Disorders: Associations and Interventions / [ed] Danilo Garcia, Trevor Archer, Richard M. Kostrzewa, Springer, 2019, 1, s. 269-281Kapitel i bok, del av antologi (Refereegranskat)
    Abstract [en]

    Background: Person-centered care sciences are experiencing rapid progress. Personalization in care services is becoming the norm, and implementation from scientific knowledge is increasingly acknowledged and mandated. Advances in personality and brain disorder research are crucial in assisting the future development of personalized care.  

    Aim: We will attempt to present glimpses into the future of personalized care with support from frontline science, measurement, and practice, updating with input from personality genetics and measurement theory.

    Outline: We present three broad developments: 1) Scientific advancements in understanding how personality and genetics are central in predicting mental health and disorders, with the potential to increase predictive diagnosis and treatment validity 2) Measurement advancements with help of trait dimensions and latent structures, with the potential to increase reliability in assessing personalized care needs and functioning 3) Practical advancements in implementing a personalized approach in care services, with the potential to increase effectiveness and satisfaction with patients. We review this glimpse into the future by referencing key findings in personality and assessment meta-analyses, Genome Wide Association Studies (GWAS), and trait measurements in psychiatric disorders.

    Conclusion: Personalizing care services will benefit practitioners and patients. We suggest and recommend that personalized care diagnosis and treatment is the way forward, and that the future will be potentially revolutionized by incorporating the presented advancements in personality research and brain sciences.

  • 219.
    Kajonius, Petri J.
    Högskolan i Skövde, Institutionen för biovetenskap. Högskolan i Skövde, Forskningscentrum för Systembiologi. University West, Sweden / University of Gothenburg, Sweden.
    The Short Personality Inventory for DSM-5 and its Conjoined structure with the Common Five-Factor Model2017Ingår i: International Journal of Testing, ISSN 1530-5058, E-ISSN 1532-7574, Vol. 17, nr 4, s. 372-384Artikel i tidskrift (Refereegranskat)
  • 220.
    Kajonius, Petri J.
    et al.
    Högskolan i Skövde, Institutionen för biovetenskap. Högskolan i Skövde, Forskningscentrum för Systembiologi. Department of Psychology, University of Gothenburg / Department of Social and Behavioral Studies, University West, Trollhättan, Sweden.
    Björkman, Therese
    Department of Social and Behavioral Studies, University West, Trollhättan, Sweden.
    Dark malevolent traits and everyday perceived stress2018Ingår i: Current Psychology, ISSN 1046-1310, E-ISSN 1936-4733Artikel i tidskrift (Refereegranskat)
    Abstract [en]

    Stress is a factor that greatly impacts our lives. Previous research has examined individual differences in relation to stress. However, research regarding malevolent personality traits in relation to how stress is perceived is limited. The purpose of thepresent study was to investigate relationships between dark malevolent personality traits; psychopathy (EPA), Machiavellianism(MACH-IV), vulnerable narcissism (HSNS), grandiose narcissism (NPI-13), and perceived stress (PSS-10) in a communitysample (N = 346). The results showed a strong positive relationship between vulnerable narcissism and perceived stress, whilegrandiose narcissism and psychopathy showed a small negative relationship with perceived stress. The discussion centers on thatnarcissism should be treated as two separate traits, and that psychopathy and Machiavellianism overlap in relation to theexperience of stress in everyday life.

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  • 221.
    Kajonius, Petri J.
    et al.
    Högskolan i Skövde, Institutionen för biovetenskap. Högskolan i Skövde, Forskningsmiljön Systembiologi. Department of Social and Behavioral Studies, University West, Sweden / Department of Psychology, University of Gothenburg, Sweden.
    Björkman, Therese
    Department of Social and Behavioral Studies, University West, Sweden.
    Individuals with dark traits have the ability but not the disposition to empathize2020Ingår i: Personality and Individual Differences, ISSN 0191-8869, E-ISSN 1873-3549, Vol. 155, artikel-id 109716Artikel i tidskrift (Refereegranskat)
    Abstract [en]

    Empathy is fundamental to social cognition and societal values. Empathy is theorized as having both the ability as well as the disposition to imagine the content of other peoples minds. We tested whether the notorious low empathy in dark personalities (Machiavellianism, psychopathy, and narcissism; the Dark Triad) is best characterized by a lack of capacity (ability) or lack of disposition (trait). Data was collected for 278 international participants through an anonymous online survey shared on the online platform LinkedIn, consisting of trait-based Dark Triad personality (SD3) and empathy (IRI), and cognitive ability (ICAR16) and ability-based empathy (MET). Dark personality traits had no relationship with ability-based empathy, but strongly so with trait-based empathy (beta = -0.47). Instead, cognitive ability explained ability-based empathy (beta = 0.31). The finding is that dark personalities in a community sample is normally cognizant to empathize but has a low disposition to do so. This finding may help shed further light on how personality is interlinked with ability.

  • 222.
    Kajonius, Petri J.
    et al.
    Högskolan i Skövde, Institutionen för biovetenskap. Högskolan i Skövde, Forskningscentrum för Systembiologi. Department of Social and Behavioral Studies, University West, Sweden / Department of Psychology, University of Gothenburg, Sweden.
    Dåderman, Anna M.
    Department of Social and Behavioral Studies, University West, Sweden.
    Conceptualizations of Personality Disorders with the Five Factor Model-count and Empathy Traits2017Ingår i: International Journal of Testing, ISSN 1530-5058, E-ISSN 1532-7574, Vol. 17, nr 2, s. 141-157Artikel i tidskrift (Refereegranskat)
    Abstract [en]

    Previous research has long advocated that emotional and behavioral disorders are related to general personality traits, such as the Five Factor Model (FFM). The addition of section III in the latest Diagnostic and Statistical Manual of Mental Disorders (DSM) recommends that extremity in personality traits together with maladaptive interpersonal functioning, such as lack of empathy, are used for identifying psychopathology and particularly personality disorders (PD). The objective of the present study was to measure dispositions for DSM categories based on normal personality continuums, and to conceptualize these with empathy traits. We used a validated FFM-count method based on the five personality factors (neuroticism, extraversion, openness, agreeableness, and conscientiousness), and related these to 4 empathy traits (emphatic concern, perspective-taking, fantasy, and personal distress). The results showed that FFM-based PD scores overall could be conceptualized using only two of the empathy traits, low emphatic concern and high personal distress. Further, specific dispositions for personality disorders were characterized with distinct empathy traits (e.g., histrionic with high fantasy, and paranoid with low perspective-taking). These findings may have both theoretical and practical implications in capturing potential for personality disorders with ease and efficiency.

  • 223.
    Kajonius, Petri J.
    et al.
    Högskolan i Skövde, Institutionen för hälsa och lärande. Department of Psychology, University of Gothenburg, Sweden.
    Persson, Björn
    Högskolan i Skövde, Institutionen för biovetenskap.
    The Dark Matter behind Values: The Dark Triad between the Big Five and Schwartz’ Value Types2014Konferensbidrag (Refereegranskat)
    Abstract [en]

    The Dark Triad offers measurement and predictive validity of egotistic and anti-social dispositions, including the factors Narcissism, Psychopathy, and Machiavellianism. Based on the well established link between personality traits and values, this study proposes that the Dark Triad can be used to understand individuals’ propensity towards including or excluding other people in their social relationships. A group of 80 human resource management students whose future comptence among other things will be to cooperate with others were measured on the Dark Triad, Schwartz’ ten Value Orientations, and two versions of the Big Five personality traits (FIPI, BFI44). The results showed consistent negative correlations between the Dark Triad and the value dimensions of concern for generalized others, as well as positive correlations between the Dark Triad and the value dimensions of concern for self. The study also concluded that the Dark Triad works as a moderator of the relationship between personality traits (Big Five) and values (Schwartz’), and substantially adds additional explained variance especially on values of exclusion. The etiology of social in-group and out-group processes in everyday life is suggested to be individuals’ dispositions for dark values, a path towards deviant and negative behaviors. 

  • 224.
    Kajonius, Petri J.
    et al.
    University of Gothenburg, Sweden.
    Persson, Björn N.
    Högskolan i Skövde, Institutionen för biovetenskap. Högskolan i Skövde, Forskningscentrum för Systembiologi.
    Jonason, Peter K.
    University of Western Sydney, Australia.
    Hedonism, Achievement, and Power: Universal Values that Characterize the Dark Triad2015Ingår i: Personality and Individual Differences, ISSN 0191-8869, E-ISSN 1873-3549, Vol. 77, s. 173-178Artikel i tidskrift (Refereegranskat)
    Abstract [en]

    Using a sample of Swedes and Americans (N = 385), we attempted to understand the Dark Triad traits (i.e., Machiavellianism, narcissism, and psychopathy) in terms of the universal social values. The Dark Triad traits correlated significantly with all 10 value types, forming a sinusoid pattern corresponding to the value model circumplex. In regression analyses, Machiavellianism and narcissism were positively associated with the values Achievement and Power, while psychopathy was positively associated with the values Hedonism, and Power. In addition, the Dark Triad traits explained significant variance over the Big Five traits in accounting for individual differences in social values. Differences between the Swedish and the US sample in the social value Achievement was mediated by the Dark Triad traits, as well as age. Given the unique complex of values accounted for by the Dark Triad traits compared to the Big Five traits, we argue that the former account for a system of self-enhancing “dark values”, often hidden but constantly contributing in evaluations of others.

  • 225.
    Kajonius, Petri J.
    et al.
    Högskolan i Skövde, Institutionen för hälsa och lärande. Högskolan i Skövde, Forskningscentrum för Systembiologi. Department of Psychology, University of Gothenburg, Gothenburg, Sweden / Network for Empowerment and Well-Being, University of Gothenburg, Gothenburg, Sweden.
    Persson, Björn N.
    Högskolan i Skövde, Institutionen för biovetenskap. Högskolan i Skövde, Forskningscentrum för Systembiologi. Network for Empowerment and Well-Being, University of Gothenburg, Gothenburg, Sweden.
    Rosenberg, Patricia
    Network for Empowerment and Well-Being, University of Gothenburg, Gothenburg, Sweden / Blekinge Center of Competence, Blekinge County Council, Karlskrona, Sweden.
    Garcia, Danilo
    Department of Psychology, University of Gothenburg, Gothenburg, Sweden / Network for Empowerment and Well-Being, University of Gothenburg, Gothenburg, Sweden / Blekinge Center of Competence, Blekinge County Council, Karlskrona, Sweden / Institute of Neuroscience and Physiology, Sahlgrenska Academy, Gothenburg, Sweden.
    The (mis)measurement of the Dark Triad Dirty Dozen: exploitation at the core of the scale2016Ingår i: PeerJ, ISSN 2167-8359, E-ISSN 2167-8359, Vol. 4, artikel-id e1748Artikel i tidskrift (Refereegranskat)
  • 226.
    Kajonius, Petri
    et al.
    Högskolan i Skövde, Institutionen för biovetenskap. Högskolan i Skövde, Forskningscentrum för Systembiologi. Department of Psychology, University of Gothenburg, Gothenburg, Sweden / Department of Psychology, University West, Trollhättan, Sweden.
    Johnson, John
    Department of Psychology, Pennsylvania State University, State College, USA.
    Assessing the Structure of the Five Factor Model of Personality (IPIP-NEO-120) in the Public Domain2019Ingår i: Europe's Journal of Psychology, ISSN 1841-0413, E-ISSN 1841-0413, Vol. 15, nr 2, s. 260-275Artikel i tidskrift (Refereegranskat)
    Abstract [en]

    Assessment of individual differences in personality traits is arguably one of the hallmarks of psychological research. Testing the structural validity of trait measurements is paramount in this endeavor. In the current study, we investigated 30 facet traits in one of the accessible and comprehensive public-domain Five Factor Model (FFM) personality inventories, IPIP-NEO-120 (Johnson, 2014), using one of the largest US samples to date (N = 320,128). We present structural loadings for all trait facets organized into respective FFM-trait domain (Neuroticism, Extraversion, Openness, Agreeableness, and Conscientiousness). Both hierarchical second-order and bi-factor models showed tolerable model fit indices, using confirmatory factor analysis in a structural equation modeling (SEM) framework. Some facet traits were substantially more representative than others for their respective trait domain, which facilitate further discussions on FFM-construct content. We conclude that IPIP-NEO is sufficiently structurally robust for future use, for the benefit of research and practice in personality assessment.

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  • 227.
    Kajonius, Petri
    et al.
    Högskolan i Skövde, Forskningscentrum för Systembiologi. Högskolan i Skövde, Institutionen för biovetenskap. University West, Sweden / University of Gothenburg, Sweden.
    Johnson, John
    Pennsylvania State University, United States.
    Sex differences in 30 facets of the five factor model of personality in the large public (N = 320,128)2018Ingår i: Personality and Individual Differences, ISSN 0191-8869, E-ISSN 1873-3549, Vol. 129, s. 126-130Artikel i tidskrift (Refereegranskat)
    Abstract [en]

    The present study reports on the scope and size of sex differences in 30 personality facet traits, using one of the largest US samples to date (N = 320,128). The study was one of the first to utilize the open access version of the Five-Factor Model of personality (IPIP-NEO-120) in the large public. Overall, across age-groups 19–69 years old, women scored notably higher than men in Agreeableness (d = 0.58) and Neuroticism (d = 0.40). Specifically, women scored d > 0.50 in facet traits Anxiety, Vulnerability, Openness to Emotions, Altruism, and Sympathy, while men only scored slightly higher (d > 0.20) than women in facet traits Excitement-seeking and Openness to Intellect. Sex gaps in the five trait domains were fairly constant across all age-groups, with the exception for age-group 19–29 years old. The discussion centers on how to interpret effects sizes in sex differences in personality traits, and tentative consequences. 

  • 228.
    Kajonius, Petri
    et al.
    Högskolan i Skövde, Institutionen för biovetenskap. Högskolan i Skövde, Forskningscentrum för Systembiologi. Department of Psychology, University of Gothenburg, Gothenburg, Sweden / Department of Behavioral Sciences, University West, Trollhättan, Sweden.
    Mac Giolla, Erik
    Department of Psychology, University of Gothenburg, Gothenburg, Sweden.
    Personality traits across countries: Support for similarities rather than differences2017Ingår i: PLoS ONE, ISSN 1932-6203, E-ISSN 1932-6203, Vol. 12, nr 6, s. 1-13, artikel-id e0179646Artikel i tidskrift (Refereegranskat)
    Abstract [en]

    In the current climate of migration and globalization, personality characteristics of individualsfrom different countries have received a growing interest. Previous research has establishedreliable differences in personality traits across countries. The present study extends thisresearch by examining 30 personality traits in 22 countries, based on an online survey inEnglish with large national samples (NTotal = 130,602). The instrument used was a comprehensive,open-source measure of the Five Factor Model (FFM) (IPIP-NEO-120). We postulatedthat differences in personality traits between countries would be small, labeling this aSimilarities Hypothesis. We found support for this in three stages. First, similarities acrosscountries were observed for model fits for each of the five personality trait structures. Second,within-country sex differences for the five personality traits showed similar patternsacross countries. Finally, the overall the contribution to personality traits from countries wasless than 2%. In other words, the relationship between a country and an individual's personalitytraits, however interesting, are small. We conclude that the most parsimonious explanationfor the current and past findings is a cross-country personality Similarities Hypothesis.

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  • 229.
    Kalathilparambil Jayanthan, Jayalal
    Högskolan i Skövde, Institutionen för biovetenskap.
    Identification of core gut bacterial community of royal pair of a fungus-growing termite, Macrotermes natalensis2019Självständigt arbete på avancerad nivå (magisterexamen), 20 poäng / 30 hpStudentuppsats (Examensarbete)
    Abstract [en]

    Approximately 30 million years ago, ancestors of fungus-growing termites started an obligate mutualistic relationship with a Basidiomycete fungus Termitomyces. The success of this obligate relation is the division of labour and reliance on termite caste gut microbial symbionts. Termites workers maintain Termitomyces fungal garden with their workforce and dual gut passage while the soldier caste protects the colony from predators. The fungal garden concurrently provides enough food for the colony members. Royal pair (a king and a queen) is the centralised caste in the colony, and they control the colony population by their massive reproduction, but their gut community composition remains unexplored. This project aimed to characterise the gut microbes associated with royal pairs of a fungus‐growing termite species Macrotermes natalensis. Four colonies were explored using high throughput sequencing of 16S rRNA gene amplicon dataset. The high-throughput sequence result showed that royal gut microbiotas were comprised of a lower number of bacterial taxa than sterile caste (workers and soldiers). This less number of bacterial taxa suggested that the royal pair gut was completely decoupled from the sterile castes gut, which indicates that the royal pair were possibly provided with a unique diet. The study also showed diversity in bacterial genus-level OTUs of royal pairs in all four colonies which indicated that there is a diet variation between the king and queen. The media predicting strategy could facilitate future cultivation efforts for targeted royal pair gut bacterial strains.

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  • 230.
    Kallio, Sakari
    et al.
    Högskolan i Skövde, Institutionen för biovetenskap. Högskolan i Skövde, Forskningscentrum för Systembiologi.
    Koivisto, Mika
    University of Turku, Finland.
    Seeing Blue As Red: A Hypnotic Suggestion Can Alter Visual Awareness of Colors2016Ingår i: International journal of clinical and experimental hypnosis, ISSN 0020-7144, E-ISSN 1744-5183, Vol. 64, nr 3, s. 261-284Artikel i tidskrift (Refereegranskat)
    Abstract [en]

    Some highly hypnotizable individuals have reported changes in objects' color with suggestions given in normal waking state. However, it is not clear whether this occurs only in their imagination. The authors show that, although subjects could imagine colors, a posthypnotic suggestion was necessary for seeing altered colors, even for a hypnotic virtuoso. She reported posthypnotic color alterations also selectively in response to specific target shapes in briefly presented object arrays. Surprisingly, another highly hypnotizable person showed a very different pattern of results. The control participants could not simulate virtuosos' results by applying cognitive strategies. The results imply that hypnosis can alter the functioning of automatic visual processes but only in some of the most hypnotizable individuals.

  • 231.
    Kallio, Sakari
    et al.
    Högskolan i Skövde, Institutionen för biovetenskap. Högskolan i Skövde, Forskningscentrum för Systembiologi. Centre for Cognitive Neuroscience, University of Turku, Turku, Finland / Turku Institute for Advanced Studies and Department of Psychology, University of Turku, Turku, Finland.
    Koivisto, Mika
    Centre for Cognitive Neuroscience, University of Turku, Turku, Finland / Turku Institute for Advanced Studies and Department of Psychology, University of Turku, Turku, Finland.
    Kaakinen, Johanna K.
    Turku Institute for Advanced Studies and Department of Psychology, University of Turku, Turku, Finland.
    Synaesthesia-type associations and perceptual changes induced by hypnotic suggestion2017Ingår i: Scientific Reports, ISSN 2045-2322, E-ISSN 2045-2322, Vol. 7, artikel-id 17310Artikel i tidskrift (Refereegranskat)
    Abstract [en]

    Are synaesthetic experiences congenital and so hard-wired, or can a functional analogue be created? We induced an equivalent of form-colour synaesthesia using hypnotic suggestions in which symbols in an array (circles, crosses, squares) were suggested always to have a certain colour. In a Stroop type-naming task, three of the four highly hypnotizable participants showed a strong synaesthesia-type association between symbol and colour. This was verified both by their subjective reports and objective eye-movement behaviour. Two resembled a projector-and one an associator-type synaesthete. Participant interviews revealed that subjective experiences differed somewhat from typical (congenital) synaesthesia. Control participants who mimicked the task using cognitive strategies showed a very different response pattern. Overall, the results show that the targeted, preconsciously triggered associations and perceptual changes seen in association with congenital synaesthesia can rapidly be induced by hypnosis. They suggest that each participant's subjective experience of the task should be carefully evaluated, especially when studying hypnotic hallucinations. Studying such experiences can increase understanding of perception, automaticity, and awareness and open unique opportunities in cognitive neuroscience and consciousness research.

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  • 232.
    Kallioinen, Minna
    et al.
    Department of Perioperative Services, Intensive Care and Pain Medicine, Turku University Hospital, Finland.
    Scheinin, Annalotta
    Department of Perioperative Services, Intensive Care and Pain Medicine, Turku University Hospital, Finland / Turku PET Centre, University of Turku and Turku University Hospital, Finland.
    Maksimow, Mikael
    Medicity Research Laboratory, University of Turku, Finland.
    Långsjö, Jaakko
    Turku PET Centre, University of Turku and Turku University Hospital, Finland / Department of Intensive Care, Tampere University Hospital, Finland.
    Kaisti, Kaike
    Turku PET Centre, University of Turku and Turku University Hospital, Finland / Department of Anesthesiology and Intensive Care, Oulu University Hospital, Finland.
    Takala, Riikka
    Department of Perioperative Services, Intensive Care and Pain Medicine, Turku University Hospital, Finland.
    Vahlberg, Tero
    Department of Clinical Medicine, Biostatistics, University of Turku and Turku University Hospital, Finland.
    Valli, Katja
    Högskolan i Skövde, Institutionen för biovetenskap. Högskolan i Skövde, Forskningsmiljön Systembiologi. Department of Psychology and Speech-Language Pathology, and Turku Brain and Mind Centre, University of Turku, Finland.
    Salmi, Marko
    Medicity Research Laboratory, University of Turku, Finland / Institute of Biomedicine, University of Turku, Finland.
    Scheinin, Harry
    Department of Perioperative Services, Intensive Care and Pain Medicine, Turku University Hospital, Finland / Turku PET Centre, University of Turku and Turku University Hospital, Finland / Integrative Physiology and Pharmacology, Institute of Biomedicine, University of Turku, Finland.
    Maksimow, Anu
    Department of Perioperative Services, Intensive Care and Pain Medicine, Turku University Hospital, Finland.
    The influence of dexmedetomidine and propofol on circulating cytokine levels in healthy subjects2019Ingår i: BMC Anesthesiology, ISSN 1471-2253, E-ISSN 1471-2253, Vol. 19, nr 1, s. 1-8, artikel-id 222Artikel i tidskrift (Refereegranskat)
    Abstract [en]

    Background: Surgery and diseases modify inflammatory responses and the immune system. Anesthetic agents also have effects on the human immune system but the responses they induce may be altered or masked by the surgical procedures or underlying illnesses. The aim of this study was to assess how single-drug dexmedetomidine and propofol anesthesia without any surgical intervention alter acute immunological biomarkers in healthy subjects. Methods: Thirty-five healthy, young male subjects were anesthetized using increasing concentrations of dexmedetomidine (n = 18) or propofol (n = 17) until loss of responsiveness (LOR) was detected. The treatment allocation was randomized. Multi-parametric immunoassays for the detection of 48 cytokines, chemokines and growth factors were used. Concentrations were determined at baseline and at the highest drug concentration for each subject. Results: The changes in the concentration of eotaxin (decrease after dexmedetomidine) and platelet-derived growth factor (PDGF, increase after propofol) were statistically significantly different between the groups. Significant changes were detected within both groups; the concentrations of monocyte chemotactic protein 1, chemokine ligand 27 and macrophage migration inhibitory factor were lower in both groups after the drug administration. Dexmedetomidine decreased the concentration of eotaxin, interleukin-18, interleukin-2Ra, stem cell factor, stem cell growth factor and vascular endothelial growth factor, and propofol decreased significantly the levels of hepatocyte growth factor, IFN-.-induced protein 10 and monokine induced by IFN-gamma, and increased the levels of interleukin-17, interleukin-5, interleukin-7 and PDGF. Conclusions: Dexmedetomidine seemed to have an immunosuppressive effect on the immune system whereas propofol seemed to induce mixed pro- and anti-inflammatory effects on the immune system. The choice of anesthetic agent could be relevant when treating patients with compromised immunological defense mechanisms. Trial registration: Before subject enrollment, the study was registered in the European Clinical Trials database (EudraCT number 2013-001496-21, The Neural Mechanisms of Anesthesia and Human Consciousness) and in ClinicalTrials.gov (Principal Investigator: Harry Scheinin, number NCT01889004, The Neural Mechanisms of Anesthesia and Human Consciousness, Part 2, on the 23rd of June 2013).

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  • 233.
    Kallionpää, R. E.
    et al.
    Department of Psychology and Speech-Language Pathology, and Turku Brain and Mind Center, University of Turku, Turku, Finland / Department of Perioperative Services, Intensive Care and Pain Medicine, Turku University Hospital, Turku, Finland.
    Scheinin, A.
    Department of Perioperative Services, Intensive Care and Pain Medicine, Turku University Hospital, Turku, Finland / Turku PET Centre, University of Turku and Turku University Hospital,Turku, Finland.
    Kallionpää, R. A.
    Institute of Biomedicine, University of Turku, Turku, Finland.
    Sandman, N.
    Department of Psychology and Speech-Language Pathology, and Turku Brain and Mind Center, Universityof Turku, Turku, Finland.
    Kallioinen, M.
    Department of Perioperative Services, Intensive Care and Pain Medicine, Turku University Hospital, Turku, Finland.
    Laitio, R.
    Turku PET Centre, University of Turku and Turku University Hospital,Turku, Finland.
    Laitio, T.
    Turku PET Centre, University of Turku and Turku University Hospital,Turku, Finland.
    Kaskinoro, K.
    Turku PET Centre, University of Turku and Turku University Hospital,Turku, Finland.
    Kuusela, T.
    Department of Physics and Astronomy, University of Turku, Turku, Finland.
    Revonsuo, Antti
    Högskolan i Skövde, Institutionen för biovetenskap. Högskolan i Skövde, Forskningscentrum för Systembiologi. Department of Psychology and Speech-Language Pathology, and Turku Brain and Mind Center, University of Turku, Turku, Finland.
    Scheinin, H.
    Department of Perioperative Services, Intensive Care and Pain Medicine, Turku University Hospital, Turku, Finland / Turku PET Centre, University of Turku and Turku University Hospital,Turku, Finland / Integrative Physiology and Pharmacology,Institute of Biomedicine, University of Turku, Turku, Finland.
    Valli, Katja
    Högskolan i Skövde, Institutionen för biovetenskap. Högskolan i Skövde, Forskningscentrum för Systembiologi. Department of Psychology and Speech-Language Pathology, and Turku Brain and Mind Center, University of Turku, Turku, Finland / Department of Perioperative Services, Intensive Care and Pain Medicine, Turku University Hospital, Turku, Finland.
    Spoken words are processed during dexmedetomidine-induced unresponsiveness2018Ingår i: British Journal of Anaesthesia, ISSN 0007-0912, E-ISSN 1471-6771, Vol. 121, nr 1, s. 270-280Artikel i tidskrift (Refereegranskat)
    Abstract [en]

    Background: Studying the effects of anaesthetic drugs on the processing of semantic stimuli could yield insights into how brain functions change in the transition from wakefulness to unresponsiveness. Here, we explored the N400 event-related potential during dexmedetomidine- and propofol-induced unresponsiveness. Methods: Forty-seven healthy subjects were randomised to receive either dexmedetomidine (n = 23) or propofol (n = 24) in this open-label parallel-group study. Loss of responsiveness was achieved by stepwise increments of pseudo-steady-state plasma concentrations, and presumed loss of consciousness was induced using 1.5 times the concentration required for loss of responsiveness. Pre-recorded spoken sentences ending either with an expected (congruous) or an unexpected (incongruous) word were presented during unresponsiveness. The resulting electroencephalogram data were analysed for the presence of the N400 component, and for the N400 effect defined as the difference between the N400 components elicited by congruous and incongruous stimuli, in the time window 300-600 ms post-stimulus. Recognition of the presented stimuli was tested after recovery of responsiveness. Results: The N400 effect was not observed during dexmedetomidine- or propofol-induced unresponsiveness. The N400 component, however, persisted during dexmedetomidine administration. The N400 component elicited by congruous stimuli during unresponsiveness in the dexmedetomidine group resembled the large component evoked by incongruous stimuli at the awake baseline. After recovery, no recognition of the stimuli heard during unresponsiveness occurred. Conclusions: Dexmedetomidine and propofol disrupt the discrimination of congruous and incongruous spoken sentences, and recognition memory at loss of responsiveness. However, the processing of words is partially preserved during dexmedetomidine-induced unresponsiveness.

  • 234.
    Kallionpää, Roosa E.
    et al.
    Department of Psychology and Speech-Language Pathology, and Turku Brain and Mind Center, University of Turku, Turku, Finland / Department of Perioperative Services, Intensive Care and Pain Medicine, Turku University Hospital, Finland.
    Pesonen, Henri
    Department of Mathematics and Statistics, University of Turku, Finland / Department of Computer Science, Aalto University, Espoo, Finland.
    Scheinin, Annalotta
    Department of Perioperative Services, Intensive Care and Pain Medicine, Turku University Hospital, Finland / Turku PET Centre, University of Turku and Turku University Hospital, Finland.
    Sandman, Nils
    Department of Psychology and Speech-Language Pathology, and Turku Brain and Mind Center, University of Turku,Finland.
    Laitio, Ruut
    Turku PET Centre, University of Turku and Turku University Hospital, Finland.
    Scheinin, Harry
    Department of Perioperative Services, Intensive Care and Pain Medicine, Turku University Hospital, Finland / Turku PET Centre, University of Turku and Turku University Hospital, Finland / Integrative Physiology and Pharmacology, Institute of Biomedicine, University of Turku, Finland.
    Revonsuo, Antti
    Högskolan i Skövde, Institutionen för biovetenskap. Högskolan i Skövde, Forskningscentrum för Systembiologi. Department of Psychology and Speech-Language Pathology, and Turku Brain and Mind Center, University of Turku, Finland.
    Valli, Katja
    Högskolan i Skövde, Institutionen för biovetenskap. Högskolan i Skövde, Forskningscentrum för Systembiologi. Department of Psychology and Speech-Language Pathology, and Turku Brain and Mind Center, University of Turku, Finland / Department of Perioperative Services, Intensive Care and Pain Medicine, Turku University Hospital, Finland.
    Single-subject analysis of N400 event-related potential component with five different methods2019Ingår i: International Journal of Psychophysiology, ISSN 0167-8760, E-ISSN 1872-7697, Vol. 144, s. 14-24Artikel i tidskrift (Refereegranskat)
    Abstract [en]

    There are several different approaches to analyze event-related potentials (ERPs) at single-subject level, and the aim of the current study is to provide information for choosing a method based on its ability to detect ERP effects and factors influencing the results. We used data from 79 healthy participants with EEG referenced to mastoid average and investigated the detection rate of auditory N400 effect in single-subject analysis using five methods: visual inspection of participant-wise averaged ERPs, analysis of variance (ANOVA) for amplitude averages in a time window, cluster-based non-parametric testing, a novel Bayesian approach and Studentized continuous wavelet transform (t-CWT). Visual inspection by three independent raters yielded N400 effect detection in 85% of the participants in at least one paradigm (active responding or passive listening), whereas ANOVA identified the effect in 68%, the cluster-method in 59%, the Bayesian method in 89%, and different versions of t-CWT in 22–59% of the participants. Thus, the Bayesian method was the most liberal and also showed the greatest concordance between the experimental paradigms (active/passive). ANOVA detected significant effect only in cases with converging evidence from other methods. The t-CWT and cluster-based method were the most conservative methods. As we show in the current study, different analysis methods provide results that do not completely overlap. The method of choice for determining the presence of an ERP component at single-subject level thus remains unresolved. Relying on a single statistical method may not be sufficient for drawing conclusions on single-subject ERPs. 

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  • 235.
    Kariminejad, Ariana
    et al.
    Kariminejad-Najmabadi Pathology & Genetics Centre, Tehran, Iran.
    Almadani, Navid
    Kariminejad-Najmabadi Pathology & Genetics Centre, Tehran, Iran.
    Khoshaeen, Atefeh
    Mehrgan Genetics Centre, Sari, Iran.
    Olsson, Björn
    Högskolan i Skövde, Institutionen för biovetenskap. Högskolan i Skövde, Forskningscentrum för Systembiologi.
    Moslemi, Ali-Reza
    Department of Pathology, University of Gothenburg, Sahlgrenska University Hospital, Gothenburg, Sweden.
    Tajsharghi, Homa
    Högskolan i Skövde, Institutionen för biovetenskap. Högskolan i Skövde, Forskningscentrum för Systembiologi. Department of Pathology, University of Gothenburg, Sahlgrenska University Hospital, Gothenburg, Sweden.
    Truncating CHRNG mutations associated with interfamilial variability of the severity of the Escobar variant of multiple pterygium syndrome2016Ingår i: BMC Genetics, ISSN 1471-2156, E-ISSN 1471-2156, Vol. 17, nr 1, artikel-id 71Artikel i tidskrift (Refereegranskat)
    Abstract [en]

    BACKGROUND:In humans, muscle-specific nicotinergic acetylcholine receptor (AChR) is a transmembrane protein with five different subunits, coded by CHRNA1, CHRNB, CHRND and CHRNG/CHRNE. The gamma subunit of AChR encoded by CHRNG is expressed during early foetal development, whereas in the adult, the γ subunit is replaced by a ε subunit. Mutations in the CHRNG encoding the embryonal acetylcholine receptor may cause the non-lethal Escobar variant (EVMPS) and lethal form (LMPS) of multiple pterygium syndrome. The MPS is a condition characterised by prenatal growth failure with pterygium and akinesia leading to muscle weakness and severe congenital contractures, as well as scoliosis.

    RESULTS:Our whole exome sequencing studies have identified one novel and two previously reported homozygous mutations in CHRNG in three families affected by non-lethal EVMPS. The mutations consist of deletion of two nucleotides, cause a frameshift predicted to result in premature termination of the foetally expressed gamma subunit of the AChR.

    CONCLUSIONS:Our data suggest that severity of the phenotype varies significantly both within and between families with MPS and that there is no apparent correlation between mutation position and clinical phenotype. Although individuals with CHRNG mutations can survive, there is an increased frequency of abortions and stillbirth in their families. Furthermore, genetic background and environmental modifiers might be of significance for decisiveness of the lethal spectrum, rather than the state of the mutation per se. Detailed clinical examination of our patients further indicates the changing phenotype from infancy to childhood.

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  • 236.
    Kariminejad, Ariana
    et al.
    Najmabadi Pathology & Genetics Center, Tehran, Iran.
    Ghaderi-Sohi, Siavash
    Najmabadi Pathology & Genetics Center, Tehran, Iran.
    Hossein-Nejad Nedai, Hamid
    Department of Pathology, Shahid Beheshti University of Medical Sciences, Tehran, Iran.
    Varasteh, Vahid
    Division of Thoracic Surgery, Shahid Beheshti University of Medical Sciences, Tehran, Iran.
    Moslemi, Ali-Reza
    Department of Pathology, University of Gothenburg, Sahlgrenska University Hospital, Gothenburg, Sweden.
    Tajsharghi, Homa
    Högskolan i Skövde, Institutionen för biovetenskap. Högskolan i Skövde, Forskningscentrum för Systembiologi. Department of Pathology, University of Gothenburg, Sahlgrenska University Hospital, Gothenburg, Sweden / Department of Clinical and Medical Genetics, University of Gothenburg, Gothenburg, Sweden.
    Lethal multiple pterygium syndrome, the extreme end of the RYR1 spectrum2016Ingår i: BMC Musculoskeletal Disorders, ISSN 1471-2474, E-ISSN 1471-2474, Vol. 17, nr 1, s. 1-5, artikel-id 109Artikel i tidskrift (Refereegranskat)
    Abstract [en]

    BACKGROUND: Lethal multiple pterygium syndrome (LMPS, OMIM 253290), is a fatal disorder associated with anomalies of the skin, muscles and skeleton. It is characterised by prenatal growth failure with pterygium present in multiple areas and akinesia, leading to muscle weakness and severe arthrogryposis. Foetal hydrops with cystic hygroma develops in affected foetuses with LMPS. This study aimed to uncover the aetiology of LMPS in a family with two affected foetuses.

    METHODS AND RESULTS: Whole exome sequencing studies have identified novel compound heterozygous mutations in RYR1 in two affected foetuses with pterygium, severe arthrogryposis and foetal hydrops with cystic hygroma, characteristic features compatible with LMPS. The result was confirmed by Sanger sequencing and restriction fragment length polymorphism analysis.

    CONCLUSIONS: RYR1 encodes the skeletal muscle isoform ryanodine receptor 1, an intracellular calcium channel with a central role in muscle contraction. Mutations in RYR1 have been associated with congenital myopathies, which form a continuous spectrum of pathological features including a severe variant with onset in utero with fetal akinesia and arthrogryposis. Here, the results indicate that LMPS can be considered as the extreme end of the RYR1-related neonatal myopathy spectrum. This further supports the concept that LMPS is a severe disorder associated with defects in the process known as excitation-contraction coupling.

  • 237.
    Karlsson, David
    Högskolan i Skövde, Institutionen för biovetenskap.
    Uppskattning av nätselektivitet och populationsstruktur av sik (Coregonus spp) i Vättern2016Självständigt arbete på grundnivå (kandidatexamen), 10 poäng / 15 hpStudentuppsats (Examensarbete)
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  • 238.
    Karlsson, Diana
    et al.
    Högskolan i Skövde, Institutionen för biovetenskap. Högskolan i Skövde, Forskningscentrum för Systembiologi.
    Pernestig, Anna-Karin
    Högskolan i Skövde, Institutionen för biovetenskap. Högskolan i Skövde, Forskningscentrum för Systembiologi.
    Ljungström, Lars
    Department of Infectious Diseases- Skaraborg Hospital, Skövde, Sweden.
    Multimarker approach for sepsis diagnostics2015Ingår i: 25th European Congress of Clinical Mircobiology and Infectious Diseases, Copenhagen, April 25-28, 2015, European Society of ClinicalMicrobiology and Infectious Diseases (ESCMID) , 2015Konferensbidrag (Refereegranskat)
    Abstract [en]

    OBJECTIVES

    The aim of this study was to assess the performance of a multimarker model in distinguishing patients with sepsis from those with non-infective systemic inflammatory response.

    METHODS

    This study is part of a prospective study of community-onset severe sepsis and septic shock in adults conducted from September 2011 to June 2012 at Skaraborg Hospital, in the western region of Sweden. The levels of 92 inflammation-related human protein biomarkers were measured simultaneously using Proseek® Multiplex Inflammation I96x96 (Olink Bioscience, Sweden) in 122 plasma samples collected from patients suspected with sepsis. After pre-processing normalization procedure, measurements of the markers were obtained as Normalized Protein eXpression (NPX) units on a log2 scale (GenEx, MultiD Analyses AB, Sweden). The study was approved by the Regional Ethical Review Board of Gothenburg (376-11). All patients enrolled provided written informed consent.

    To reduce the number of markers, factor analysis was performed. Thereafter, a multimarker model for classification was derived using discriminant analysis. The multimarker model consisted of a linear function of the selected markers. Cross-validation was performed by classifying each sample by the discriminant function derived from all samples other than that specific sample. The performance was assessed as area under receiving operating characteristic (ROC) curve. The cut-off for sensitivity and specificity was derived from the cut score of the discriminant function. Statistical analyses were performed in SPSS 22.0 (IBM Corporation Somers, NY USA).

    RESULTS

    Of the 122 samples, 80 (66%) were from patients diagnosed with sepsis and 42 from patients with non-infective systemic inflammatory response syndrome (SIRS). The five markers selected for the multimarker model were interleukin-6 (IL-6), cystatin D (CST5), delta and notch-like epidermal growth factor-related receptor (DNER), STAM-binding protein (STAMPB), macrophage colony-stimulating factor 1 (CSF 1). Every single marker was statistically different between the groups (p value < 0.001), except for DNER (p value 0.064) and STAMPB (p value 0.060). The area under ROC was higher for the multimarker model (81%) than for each biomarker separately (Figure 1). The accuracy for the multimarker model was 72% [64-80, 95% CI]; sensitivity 84% [77-91, 95% CI]; specificity 60% [51-69, 95% CI]; positive predictive value 79% [72-86, 95% CI]; and negative predictive value 66% [58-74, 95% CI].

    CONCLUSION

    A higher power of discrimination is obtained by combining more than one biomarker. However, the multimarker candidates identified in this study need further assessment.

  • 239.
    Karlsson, Louise
    Högskolan i Skövde, Institutionen för biovetenskap.
    Stress: From a biological, social, and psychological perspective2018Självständigt arbete på grundnivå (kandidatexamen), 15 poäng / 22,5 hpStudentuppsats (Examensarbete)
    Abstract [en]

    Over the years stress has been a term lacking one clear and specific definition. In general, the term stress has been used mostly as an explanation of a response or reaction to a stressor. A stressor can be of both physiological and behavioral character. The experience of stress can occur both due to a real or a perceived stressor. In this literature review, the concept of stress is viewed with insights from biological, psychological, and social perspectives. The stress response is described biologically with the central nervous system (CNS), the brain, and the hypothalamic-pituitary-adrenal (HPA) axis. Social and psychological stress are concepts related to how stress is perceived by the mind and due to social surroundings which is described in relation to social support, self-efficacy, the locus of control and cognitive appraisal. Dealing with stress can be done through coping which refers to the individual capacity to handle a stressor and has generally been divided into two categories, active/passive coping and problem-focused/emotion-focused coping. Depending on the individual resources to cope with a stressor and the ability to decrease the stress response when needed, the long-term effects of stress can therefore vary between individuals. It has been found that positive coping (known as reducing stress) can increase the anterior cingulate cortex (ACC) volume and decrease anxiety and depression. The prefrontal cortex (PFC), the hippocampus, and the amygdala are closely linked to the ACC and affect emotions, learning, and memory related to the stress response.

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  • 240.
    Karlsson, Markus
    Högskolan i Skövde, Institutionen för biovetenskap.
    The Neuroscience of Decision Making: The Importance of Emotional Neural Circuits in Decision Making2018Självständigt arbete på grundnivå (kandidatexamen), 15 poäng / 22,5 hpStudentuppsats (Examensarbete)
    Abstract [en]

    The neuroscience of decision making is laying the puzzle of how the brain computes decisions. It tries to sort out which factors are responsible for causing us to choose one way or the other. This thesis reviews to what extent emotional brain processes and their neural circuits impact decision making. The somatic marker hypothesis (SMH) provides a solid dual-system framework for decision making. Dissociating an impulsive system, in which the amygdala is central, and a reflective system mediated by the ventromedial prefrontal cortex(VMPFC). The SMH emphasizes the function of the VMPFC as necessary and crucial formaking favorable long-term decisions. Research on moral decision making also shows that similar systems as used by the SMH has a key role in how we think about moral dilemmas as well. Damage or maldevelopment of these neural circuits can cause myopia for the future and deeply immoral behavior. Abnormalities in emotional neuronal circuits can also be linked to addictive behavior and psychopathy. The findings on decision making and its neuralsubstrates dismantle the common sense notion of free will and moral responsibility. An explanation of how the feeling of free will arises is given using the Interpreter system theoryof consciousness. Moral responsibility without the need for a free will is defended by analternative approach with a framework of a brain in-control versus out-of-control.

  • 241.
    Karpushevskaia, Anastasiia
    et al.
    AtlantNIRO, Kaliningrad, Russian Federation.
    Nielsen, Anders
    DTU Aqua - National Institute of Aquatic Resources, Charlottenlund, Denmark.
    Mikhaylov, Andrey
    Atlantic Research Institute of Fisheries and Oceanography (AtlantNIRO), Moscow, Russian Federation.
    Luzenczyk, Anna
    National Marine Fisheries Research Institute, Gdynia, Poland.
    Florin, Ann-Britt
    Swedish University of Agricultural Sciences Institute of Coastal Research, Öregrund, Sweden.
    Albert, Anu
    Estonian Marine Institute, University of Tartu, Tartu, Estonia.
    Berg, Casper Willestofte
    DTU Aqua National Institute of Aquatic Resources, Section for Fisheries Advice, Charlottenlund, Denmark.
    Ustups, Didzis
    Institute of Food Safety Animal Health and Environment (BIOR), Fish Resources Research Department, Riga, Latvia.
    Svecovs, Fausts
    Institute of Food Safety Animal Health and Environment (BIOR), Fish Resources Research Department, Riga, Latvia.
    Bastardie, François
    DTU Aqua, National Institute of Aquatic Resources, Charlottenlund, Denmark.
    Kornilovs, Georgs
    Institute of Food Safety Animal Health and Environment (BIOR), Fish Resources Research Department, Riga, Latvia.
    Strods, Guntars
    Institute of Food Safety Animal Health and Environment (BIOR), Fish Resources Research Department, Riga, Latvia.
    Strehlow, Harry Vincent
    Thünen Institute, Baltic Sea Fisheries, Rostock, Germany.
    Degel, Henrik
    DTU Aqua, National Institute of Aquatic Resources, Section for Monitoring and Data, Charlottenlund, Denmark.
    Karpushevskiy, Igor
    AtlantNIRO, Kaliningrad, Russian Federation.
    Sics, Ivo
    Institute of Food Safety Animal Health and Environment (BIOR), Fish Resources Research Department, Riga, Latvia.
    Horbowy, Jan
    National Marine Fisheries Research Institute, Gdynia, Poland.
    Raitaniemi, Jari
    Natural Resources Institute Finland, Turku, Finland.
    Boje, Jesper
    DTU Aqua, Arctic Section, Charlottenlund, Denmark.
    Hjelm, Joakim
    Swedish University of Agricultural Sciences, Institute of Marine Research, Lysekil, Sweden.
    Lövgren, Johan
    Swedish University of Agricultural Sciences, Institute of Marine Research, Lysekil, Sweden.
    Pönni, Jukka
    Natural Resources Institute Finland, Natural resources and bioproduction, Helsinki, Finland.
    Hommik, Kristiina
    Estonian Marine Institute, University of Tartu, Tartu, Estonia.
    Öhman, Kristin
    Swedish University of Agricultural Sciences, Department of Aquatic Resources, Lysekil, Sweden.
    Radtke, Krzysztof
    National Marine Fisheries, Research Institute, Gdynia, Poland.
    Eero, Margit
    DTU Aqua, National Institute of Aquatic Resources, Charlottenlund, Denmark.
    Storr-Paulsen, Marie
    DTU Aqua, National Institute of Aquatic Resources, Section for Fisheries Advice, Charlottenlund, Denmark.
    Plikshs, Maris
    Institute of Food Safety Animal Health and Environment (BIOR), Riga, Latvia.
    Pedersen, Martin Wæver
    DTU Aqua, National Institute of Aquatic Resources, Charlottenlund, Denmark.
    Casini, Michele
    Swedish University of Agricultural Sciences, Institute of Marine Research, Lysekil, Sweden.
    Bergenius, Mikaela
    Swedish University of Agricultural Sciences, Department of Aquatic Resources, Lysekil, Sweden.
    Holmgren, Noél
    Högskolan i Skövde, Institutionen för biovetenskap. Högskolan i Skövde, Forskningscentrum för Systembiologi.
    Kaljuste, Olavi
    Swedish University of Agricultural Sciences, Institute of Coastal Research, Öregrund, Sweden.
    Afanasyev, Pavel
    Atlantic Research Institute of Fisheries and Oceanography (AtlantNIRO), Moscow, Russian Federation.
    Gasyukov, Pavel
    AtlantNIRO, Kaliningrad, Russian Federation.
    Jounela, Pekka
    Natural Resources Institute Finland, Statistical methods, Turku Finland.
    Oeberst, Rainer
    Thünen Institute, Baltic Sea Fisheries, Rostock, Germany.
    Statkus, Romas
    Fisheries Service under the Ministry of Agriculture, Division of Fisheries Research and Science, Klaipeda, Lithuania.
    Carlshamre, Sofia
    Swedish University of Agricultural Sciences, Institute of Marine Research, Lysekil, Sweden.
    Jonusas, Stanislovas
    European Commission Directorate for Maritime Affairs and Fisheries, Brussels, Belgium.
    Neuenfeldt, Stefan
    DTU Aqua, National Institute of Aquatic Resources, Section for Fisheries Advice Population Ecology and Genetics, Charlottenlund, Denmark.
    Stoetera, Sven
    Thünen Institute Baltic Sea Fisheries, Rostock, Germany.
    Smolinski, Szymon
    National Marine Fisheries Research Institute, Gdynia, Poland.
    Raid, Tiit
    Estonian Marine Institute University of Tartu, Tallinn, Estonia.
    Arula, Timo
    Estonian Marine Institute, University of Tartu, Dept. of Ecodynamics, Lootsiza, Estonia.
    Gröhsler, Tomas
    Thünen Institute Baltic Sea Fisheries, Rostock, Germany.
    Zolubas, Tomas
    Fisheries Service under the Ministry of Agriculture, Vilnius, Lithuania.
    Krumme, Uwe
    Thünen Institute Baltic Sea Fisheries, Rostock, Germany.
    Amosova, Viktoriia
    AtlantNIRO, Kaliningrad, Russian Federation.
    Grygiel, Wlodzimierz
    National Marine Fisheries Research Institute, Gdynia, Poland.
    Pekcan-Hekim, Zeynep
    Swedish University of Agricultural Sciences, Institute of Coastal Research, Öregrund, Sweden.
    Mirny, Zuzanna
    National Marine Fisheries Research Institute, Gdynia, Poland.
    Report of the Baltic Fisheries Assessment Working Group (WGBFAS), 12-19 April 2016, ICES HQ, Copenhagen, Denmark2016Rapport (Refereegranskat)
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  • 242.
    Kazemi, Ali
    et al.
    Högskolan i Skövde, Institutionen för hälsa och lärande. Högskolan i Skövde, Forskningsspecialiseringen Hälsa och Lärande.
    Kajonius, Petri
    Högskolan i Skövde, Institutionen för biovetenskap. Högskolan i Skövde, Forskningscentrum för Systembiologi.
    Variations in user-oriented elderly care: a multilevel approach2017Ingår i: International Journal of Quality and Service Sciences, ISSN 1756-669X, E-ISSN 1756-6703, Vol. 9, nr 2, s. 138-147Artikel i tidskrift (Refereegranskat)
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  • 243.
    Kazemi, Ali
    et al.
    Högskolan i Skövde, Institutionen för hälsa och lärande. Högskolan i Skövde, Forskningsspecialiseringen Hälsa och Lärande.
    Kajonius, Petri J.
    Högskolan i Skövde, Institutionen för biovetenskap. Högskolan i Skövde, Forskningscentrum för Systembiologi.
    Cost and satisfaction trends in Swedish elderly home care2016Ingår i: Home Health Care Management & Practice, ISSN 1084-8223, E-ISSN 1552-6739, Vol. 28, nr 4, s. 250-255Artikel i tidskrift (Refereegranskat)
  • 244.
    Keane, Simon
    et al.
    Högskolan i Skövde, Institutionen för hälsovetenskaper. Högskolan i Skövde, Forskningsmiljön hälsa, hållbarhet och digitalisering.
    Améen, Sophie
    Högskolan i Skövde, Institutionen för hälsovetenskaper. Högskolan i Skövde, Forskningsmiljön hälsa, hållbarhet och digitalisering.
    Lindlöf, Angelica
    Högskolan i Skövde, Institutionen för biovetenskap. Högskolan i Skövde, Forskningsmiljön Systembiologi.
    Ejeskär, Katarina
    Högskolan i Skövde, Institutionen för hälsovetenskaper. Högskolan i Skövde, Forskningsmiljön hälsa, hållbarhet och digitalisering.
    Low DLG2 gene expression, a link between 11q-deleted and MYCN-amplified neuroblastoma, causes forced cell cycle progression, and predicts poor patient survival2020Ingår i: Cell Communication and Signaling, ISSN 1478-811X, E-ISSN 1478-811X, Vol. 18, nr 1, artikel-id 65Artikel i tidskrift (Refereegranskat)
    Abstract [en]

    BACKGROUND: Neuroblastoma (NB) is a childhood neural crest tumor. There are two groups of aggressive NBs, one with MYCN amplification, and another with 11q chromosomal deletion; these chromosomal aberrations are generally mutually exclusive. The DLG2 gene resides in the 11q-deleted region, thus makes it an interesting NB candidate tumor suppressor gene. METHODS: We evaluated the association of DLG2 gene expression in NB with patient outcomes, stage and MYCN status, using online microarray data combining independent NB patient data sets. Functional studies were also conducted using NB cell models and the fruit fly. RESULTS: Using the array data we concluded that higher DLG2 expression was positively correlated to patient survival. We could also see that expression of DLG2 was inversely correlated with MYCN status and tumor stage. Cell proliferation was lowered in both 11q-normal and 11q-deleted NB cells after DLG2 over expression, and increased in 11q-normal NB cells after DLG2 silencing. Higher level of DLG2 increased the percentage of cells in the G2/M phase and decreased the percentage of cells in the G1 phase. We detected increased protein levels of Cyclin A and Cyclin B in fruit fly models either over expressing dMyc or with RNAi-silenced dmDLG, indicating that both events resulted in enhanced cell cycling. Induced MYCN expression in NB cells lowered DLG2 gene expression, which was confirmed in the fly; when dMyc was over expressed, the dmDLG protein level was lowered, indicating a link between Myc over expression and low dmDLG level. CONCLUSION: We conclude that low DLG2 expression level forces cell cycle progression, and that it predicts poor NB patient survival. The low DLG2 expression level could be caused by either MYCN-amplification or 11q-deletion. Video Abstract.

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  • 245.
    Khalif, Eman
    Högskolan i Skövde, Institutionen för biovetenskap.
    Your Not So Neutral Brain: The Role of the Amygdala in Implicit Racial Bias2017Självständigt arbete på grundnivå (kandidatexamen), 15 poäng / 22,5 hpStudentuppsats (Examensarbete)
    Abstract [en]

    The aim of this thesis is to investigate whether the amygdala plays a significant role in implicit racial bias and to explore the possible explanations that may underlie race-related amygdala neural activity specifically in White and Black Americans. In order to answer these questions, a literature review of several studies is presented. Most of these studies have shown that amygdala plays a crucial role in implicit racial bias since greater amygdala activation was positively correlated with greater implicit racial bias. Hence, subjects that showed greater amygdala activation measured by fMRI also showed greater pro-White or anti-Black bias measured by the implicit association test. However, a few lesion studies on a patient (SP) with a bilateral amygdala damage concluded that the amygdala is not critical for implicit racial bias. Further research is needed to determine the actual role the amygdala plays in implicit racial bias specifically when observing Black American faces. Subsequently, alternative explanations that might explain race-related amygdala activation will be discussed briefly. In essence, the familiarity explanation and the culturally learned negative racial bias.

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    Your Not So Neutral Brain
  • 246.
    Khan, Sabeen Asad
    Högskolan i Skövde, Institutionen för biovetenskap.
    Identifcation of serum biomarkers in patients of exfoliative glaucoma in Scandanavian population.: Autoimmune profiling by microarray technology.2019Självständigt arbete på avancerad nivå (masterexamen), 30 poäng / 45 hpStudentuppsats (Examensarbete)
    Abstract [en]

    Glaucoma is the leading cause of irreversible blindness, estimated to affect more than 79 million people by the year 2020. It is a group of optic neuropathies that is found to be associated with autoimmunity. One of its types is exfoliative glaucoma which is more prevalent in certain areas of the world including Scandinavia. It is more aggressive and often resistant to conventional therapy. The best treatment options for glaucoma lies at the early detection of the disease. The aim of the study was to identify serum biomarkers in patients of exfoliative glaucoma in the Scandinavian population. Serum samples of 30 patients of exfoliative glaucoma and 10 control subjects were profiled on epoxy coated protein microarrays expressing immobilized His-tagged human antigens. 3072 antigens were selected after a literature review which included the ones expressed in eye and retina. Protein-microarrays were incubated with sera, and occurring immunoreactivities were visualized with fluorescence labelled secondary antibodies. To detect changes, spot intensities were digitized and analysed with different statistical methods. Binary logistic regression was used to classify diseased and controls. A significant increase of antibodies against IRAK4 antigen was detected among serum samples of the controls (p = 0.002) as compared to the exfoliative glaucoma patients. Antibodies against four other antigens were found to be more prevalent in serum samples of exfoliative glaucoma patients although not significantly. These included FUT2, VAV2, and GPATCH8 and PFKFB1. The logistic regression was able to classify diseased and controls with 100 percent accuracy depending on 11 selected reactive antigens. Out of the 3072 antigens, IRAK4 was found to be the only significant antigen with increased reactivity in controls as compared to exfoliative glaucoma patients. IRAK4 has a role in innate immunity and signal transduction, antibodies against it may have a neuroprotective effect in glaucoma. However, this is an initial exploratory study based on only 40 samples and further experiments with a larger sample size needs to be performed.

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    Exfoliative glaucoma
  • 247.
    Kia, Richard
    et al.
    Univ Liverpool, Dept Mol & Clin Pharmacol, MRC Ctr Drug Safety Sci, Liverpool, England.
    Kelly, Lorna
    Univ Liverpool, Dept Mol & Clin Pharmacol, England / Stem Cells Safer Med, London, England.
    Sison-Young, Rowena L. C.
    Univ Liverpool, Dept Mol & Clin Pharmacol, MRC Ctr Drug Safety Sci, Liverpool, England.
    Zhang, Fang
    Univ Liverpool, Dept Mol & Clin Pharmacol, England / Stem Cells Safer Med, London, England.
    Pridgeon, Chris S.
    Univ Liverpool, Dept Mol & Clin Pharmacol, England / Stem Cells Safer Med, London, England.
    Heslop, James A.
    Univ Liverpool, Dept Mol & Clin Pharmacol, MRC Ctr Drug Safety Sci, Liverpool, England.
    Metcalfe, Pete
    Univ Liverpool, Dept Mol & Clin Pharmacol, MRC Ctr Drug Safety Sci, Liverpool, England.
    Kitteringham, Neil R.
    Univ Liverpool, Dept Mol & Clin Pharmacol, England / Stem Cells Safer Med, London, England.
    Baxter, Melissa
    Univ Manchester, Fac Life Sci, Manchester, England / Univ Cent Lancashire, Sch Med & Dent, Preston, England.
    Harrison, Sean
    Stem Cells Safer Med, London, England / Acad Hlth Sci Ctr, Fac Med & Human Sci, Ctr Endocrinol & Diabet,Inst Human Dev, Manchester, England.
    Hanley, Neil A.
    Stem Cells Safer Med, London, England / Univ Manchester, Manchester Acad Hlth Sci Ctr, Fac Med & Human Sci, Ctr Endocrinol & Diabet,Inst Human Dev, Manchester, England / Cent Manchester Univ Hosp NHS Fdn Trust, Endocrinol Dept, Manchester England.
    Burke, Zoe D.
    Stem Cells Safer Med, London, England / Univ Bath, Dept Biol & Biochem, Ctr Regenerat Med, Bath, England.
    Storm,, Mike P.
    Stem Cells Safer Med, London, England / Univ Bath, Dept Biol & Biochem, Ctr Regenerat Med, Bath, England.
    Welham, Melanie J.
    Univ Bath, Dept Biol & Biochem, Ctr Regenerat Med, Bath, England.
    Tosh, David
    Stem Cells Safer Med, London, England / Univ Bath, Dept Biol & Biochem, Ctr Regenerat Med, Bath, England.
    Küppers-Munther, Barbara
    Högskolan i Skövde, Institutionen för biovetenskap. Högskolan i Skövde, Forskningscentrum för Systembiologi. Takara Bio Europe AB, Gothenburg, Sweden.
    Edsbagge, Josefina
    Takara Bio Europe AB, Gothenburg, Sweden.
    Lewis, Philip J. Starkey
    Univ Edinburgh, MRC Ctr Regenerat Med, Edinburgh EH16 4UU, Midlothian, Scotland.
    Bonner, Frank
    Stem Cells Safer Med, London, England.
    Harpur, Ernie
    Stem Cells Safer Med, London, England / Newcastle Univ, Inst Cellular Med, Sch Med, Newcastle Upon Tyne NE2 4HH, Tyne & Wear, England.
    Sidaway, James
    Univ Edinburgh, MRC Ctr Regenerat Med, Edinburgh EH16 4UU, Midlothian, Scotland / AstraZeneca R&D, Drug Safety & Metab, Cheshire, England.
    Bowes, Joanne
    Univ Edinburgh, MRC Ctr Regenerat Med, Edinburgh EH16 4UU, Midlothian, Scotland / AstraZeneca R&D, Drug Safety & Metab, Cheshire, England.
    Fenwick, Stephen W.
    Aintree Univ Hosp NHS Fdn Trust, North Western Hepatobiliary Unit, Liverpool, England.
    Malik, Hassan
    Aintree Univ Hosp NHS Fdn Trust, North Western Hepatobiliary Unit, Liverpool, England.
    Goldring, Chris E. P.
    Univ Liverpool, Dept Mol & Clin Pharmacol, MRC Ctr Drug Safety Sci, Liverpool, England / Stem Cells Safer Med, London England.
    Park, B. Kevin
    Univ Liverpool, Dept Mol & Clin Pharmacol, MRC Ctr Drug Safety Sci, Liverpool, England / Stem Cells Safer Med, London, England.
    MicroRNA-122: a novel hepatocyte-enriched in vitro marker of drug-induced cellular toxicity2015Ingår i: Toxicological Sciences, ISSN 1096-6080, E-ISSN 1096-0929, Vol. 144, nr 1, s. 173-185Artikel i tidskrift (Refereegranskat)
    Abstract [en]

    Emerging hepatic models for the study of drug-induced toxicity include pluripotent stem cell-derived hepatocyte-like cells (HLCs) and complex hepatocyte-non-parenchymal cellular coculture to mimic the complex multicellular interactions that recapitulate the niche environment in the human liver. However, a specific marker of hepatocyte perturbation, required to discriminate hepatocyte damage from non-specific cellular toxicity contributed by non-hepatocyte cell types or immature differentiated cells is currently lacking, as the cytotoxicity assays routinely used in in vitro toxicology research depend on intracellular molecules which are ubiquitously present in all eukaryotic cell types. In this study, we demonstrate that microRNA-122 (miR-122) detection in cell culture media can be used as a hepatocyte-enriched in vitro marker of drug-induced toxicity in homogeneous cultures of hepatic cells, and a cell-specific marker of toxicity of hepatic cells in heterogeneous cultures such as HLCs generated from various differentiation protocols and pluripotent stem cell lines, where conventional cytotoxicity assays using generic cellular markers may not be appropriate. We show that the sensitivity of the miR-122 cytotoxicity assay is similar to conventional assays that measure lactate dehydrogenase activity and intracellular adenosine triphosphate when applied in hepatic models with high levels of intracellular miR-122, and can be multiplexed with other assays. MiR-122 as a biomarker also has the potential to bridge results in in vitro experiments to in vivo animal models and human samples using the same assay, and to link findings from clinical studies in determining the relevance of in vitro models being developed for the study of drug-induced liver injury.

  • 248.
    Klarén, Anton
    Högskolan i Skövde, Institutionen för biovetenskap.
    Dispositional optimism and attentional bias to happy facial expressions2018Självständigt arbete på grundnivå (kandidatexamen), 15 poäng / 22,5 hpStudentuppsats (Examensarbete)
    Abstract [en]

    Research suggests that the human attentional system is biased towards emotional events in the environment. This attentional bias is believed to be an adaptive function that can provide survival benefits for the organisms that possess it. Dispositional optimism is a trait defined as a general expectation that good things will happen in the future. This trait has received interest as an adaptive trait that has a multitude of psychological and physical benefits for the individuals who exhibit it. The aim of this study is to examine whether there is a difference in the attentional bias towards happy and angry facial expressions based on level of dispositional optimism using the dot-probe paradigm. Thirty-two psychologically and neurologically healthy females (mean age = 26.5, SD = 5.8) participated in the study. They completed a questionnaire measuring dispositional optimism and performed the dot-probe task in a laboratory setting in the University of Skövde. In the dot- probe task a short exposure (100 ms) of photographs depicting happy, angry and neutral facial expressions was used as emotional cues. A general bias towards happy faces across all participants was detected. Also, a clear trend towards an interaction between DO and AB to emotional faces was found in the group high in DO displaying and AB towards happy facial expressions. This study implies that for the psychologically and neurologically healthy population, a fast operating and automatic AB for positive stimuli exists, moreover, this AB may be modulated by individual differences in DO.

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  • 249.
    Koberg, Lena
    Högskolan i Skövde, Institutionen för biovetenskap.
    The menopausal brain: Effects of estrogen depletion on cognition2018Självständigt arbete på grundnivå (kandidatexamen), 15 poäng / 22,5 hpStudentuppsats (Examensarbete)
    Abstract [en]

    Menopause is a major reproductive-related event in a woman’s life, occurring naturally at around the age of fifty years. Accompanying menopause is a drastic decrease in estrogen levels. Estrogen receptors are present throughout the human brain: e.g., in regions such as the hippocampus and prefrontal cortex, both involved in cognition. Given that about half of the world’s population is female, it is important to examine if and how cognition is affected by the menopausal estrogen depletion, both at the level of public health, and at the individual level. Studies within the field show diverse results due to a wide range of methodology among studies. Behavioral studies foremost point towards a potential estrogenic effect on verbal short- and long-term memory. Structural and functional neuroimaging, together with animal studies, mainly show structural and functional alterations in the hippocampus and prefrontal cortex that may be related to changes in estrogen levels. Taken together, this thesis reviews estrogenic effects on different cognitive functions, as well as structural and functional changes in the brain in relation to the menopausal estrogen depletion.

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    fulltext
  • 250.
    Koivisto, Mika
    et al.
    Department of Psychology, University of Turku, Turun yliopisto, Finland / Centre for Cognitive Neuroscience, University of Turku, Turun yliopisto, Finland.
    Grassini, Simone
    Department of Psychology, University of Turku, Turun yliopisto, Finland / Centre for Cognitive Neuroscience, University of Turku, Turun yliopisto, Finland.
    Hurme, Mikko
    Department of Psychology, University of Turku, Turun yliopisto, Finland / Centre for Cognitive Neuroscience, University of Turku, Turun yliopisto, Finland.
    Salminen-Vaparanta, Niina
    Department of Psychology, University of Turku, Turun yliopisto, Finland / Centre for Cognitive Neuroscience, University of Turku, Turun yliopisto, Finland.
    Railo, Henry
    Department of Psychology, University of Turku, Turun yliopisto, Finland / Centre for Cognitive Neuroscience, University of Turku, Turun yliopisto, Finland.
    Vorobyev, Victor
    Department of Psychology, University of Turku, Turun yliopisto, Finland / Centre for Cognitive Neuroscience, University of Turku, Turun yliopisto, Finland.
    Tallus, Jussi
    Department of Radiology, Turku University Hospital, Turun yliopisto, Finland.
    Paavilainen, Teemu
    Department of Radiology, Turku University Hospital, Turun yliopisto, Finland.
    Revonsuo, Antti
    Högskolan i Skövde, Institutionen för biovetenskap. Högskolan i Skövde, Forskningscentrum för Systembiologi. Department of Psychology, University of Turku, Turun yliopisto, Finland / Centre for Cognitive Neuroscience, University of Turku, Turun yliopisto, Finland.
    TMS-EEG reveals hemispheric asymmetries in top-down influences of posterior intraparietal cortex on behavior and visual event-related potentials2017Ingår i: Neuropsychologia, ISSN 0028-3932, E-ISSN 1873-3514, Vol. 107, s. 94-101Artikel i tidskrift (Refereegranskat)
    Abstract [en]

    Clinical data and behavioral studies using transcranial magnetic stimulation (TMS) suggest right-hemisphere dominance for top-down modulation of visual processing in humans. We used concurrent TMS-EEG to directly test for hemispheric differences in causal influences of the right and left intraparietal cortex on visual event-related potentials (ERPs). We stimulated the left and right posterior part of intraparietal sulcus (IPS1) while the participants were viewing and rating the visibility of bilaterally presented Gabor patches. Subjective visibility ratings showed that TMS of right IPS shifted the visibility toward the right hemifield, while TMS of left IPS did not have any behavioral effect. TMS of right IPS, but not left one, reduced the amplitude of posterior N1 potential, 180–220 ms after stimulus-onset. The attenuation of N1 occurred bilaterally over the posterior areas of both hemispheres. Consistent with previous TMS-fMRI studies, this finding suggests that the right IPS has top-down control on the neural processing in visual cortex. As N1 most probably reflects reactivation of early visual areas, the current findings support the view that the posterior parietal cortex in the right hemisphere amplifies recurrent interactions in ventral visual areas during the time-window that is critical for conscious perception.

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