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  • 1201.
    Zhang, Hong
    et al.
    Högskolan i Skövde, Institutionen för vård och natur. Högskolan i Skövde, Forskningscentrum för Systembiologi.
    Wang, Da-Wei
    Högskolan i Skövde, Institutionen för vård och natur. Högskolan i Skövde, Forskningscentrum för Systembiologi. Department of Stomatology, The Third Hospital of Hebei Medical University, Hebei, China.
    Adell, Gunnar
    Department of Oncology, Karolinska University Hospital, Karolinska, Sweden.
    Sun, Xiao-Feng
    Division of Oncology, Department of Clinical and Experimental Medicine, Faculty of Heath Science, Linköping University, Sweden .
    WRAP53 is an independent prognostic factor in rectal cancer- a study of Swedish clinical trial of preoperative radiotherapy in rectal cancer patients2012Ingår i: BMC Cancer, ISSN 1471-2407, E-ISSN 1471-2407, Vol. 12, s. 294-Artikel i tidskrift (Refereegranskat)
    Abstract [en]

    Background: Expression of WRAP53 protein has oncogenic properties and it is up regulated in several types of tumors. Methods: We examined expression of WRAP53 protein in rectal cancers and analyzed its relationship to the response to preoperative radiotherapy and patient survival. The WRAP53 protein was examined by immunohistochemistry in normal mucosa, primary tumors and lymph node metastases from 143 rectal cancer patients participated in a Swedish clinical trial of preoperative radiotherapy. Results: Frequency of WRAP53 protein expression was increased in primary rectal cancer compared to the normal mucosa (p < 0.05). In non-radiotherapy group positive WRAP53 in primary tumors (p = 0.03, RR, 3.73, 95% CI, 1.13-11.89) or metastases (p = 0.01, RR, 4.11, 95% CI, 1.25-13.14), was associated with poor prognosis independently of stages and differentiations. In radiotherapy group, positive WRAP53 in the metastasis correlated with better survival (p = 0.04). An interaction analysis showed that the correlations of WRAP53 with the prognostic significance with and without radiotherapy in the metastasis differed (p = 0.01). In the radiotherapy group, expression of WRAP53 in metastases gave a better outcome (p = 0.02, RR, 0.32, 95% CI, 0.13-0.84), and an interaction analysis showed significance between the two groups (p = 0.01). Conclusion: WRAP53 may be a new biomarker used to predict prognosis and to select suitable patients for preoperative radiotherapy.

  • 1202.
    Zhang, Hong
    et al.
    Högskolan i Skövde, Institutionen för vård och natur. Högskolan i Skövde, Forskningscentrum för Systembiologi.
    Widegren, Emma
    Linkoping Univ, Dept Oncol, Inst Clin & Expt Med, Linkoping, Sweden .
    Wang, Da-Wei
    Hebei Med Univ, Hosp 3, Dept Stomatol, Shijiazhuang, Peoples R China.
    Sun, Xiao-Feng
    Linkoping Univ, Dept Oncol, Inst Clin & Expt Med, Linkoping, Sweden .
    SPARCL1: a potential molecule associated with tumor diagnosis, progression and prognosis of colorectal cancer2011Ingår i: Tumor Biology, ISSN 1010-4283, E-ISSN 1423-0380, Vol. 32, nr 6, s. 1225-1231Artikel i tidskrift (Refereegranskat)
    Abstract [en]

    We investigated whether SPARCL1 played an essential role in tumor initiation, formation and progression of colorectal carcinomas. In this study, we examined expression of SPARCL1 protein in the normal colorectal mucosa, adjacent normal mucosa and primary and lymph node metastases from colorectal cancer patients. In matched patients, we found that SPARCL1 was negative in the distant normal colorectal mucosa, weakly expressed in the adjacent normal mucosa, strongly expressed in primary colorectal adenocarcinomas and slightly expressed in their lymph node metastases. A similar pattern was observed in the SPARCL1 expression from our series of non-matched colorectal cancer patients. The strongest expression and highest frequency of the SPARCL1 protein were found in the primary cancers. Interestingly, in the primary tumors, the frequency of SPARCL1 expression was significantly increased from the Dukes' A to Dukes' B tumors and then decreased gradually from the Dukes' B to C and D tumors. There was no difference in the intensity of SPARCL1 expression between the central areas and invasion margins of the primary tumors. Moreover, the SPARCL1 protein was more strongly expressed in the highly differentiated tumors than the lower differentiated ones. The patients with positive expression of SPARCL1 in their tumors had worse prognosis than the patients with SPARCL1-negative ones, even after the analyses by Multivariate and Interaction method. Expression of SPARCL1 protein might be a valuable biomarker for early diagnosis in colorectal cancers and further predicting patients' prognosis.

  • 1203.
    Zhang, Zhi-Yong
    et al.
    Linkoping Univ, Inst Clin & Expt Med, Dept Oncol, S-58185 Linkoping, Sweden / Tangshan Gongren Hosp, Dept Pathol, Tangshan, Peoples R China / Hebei Med Univ, Hosp 1, Lab Ctr, Shijiazhuang, Peoples R China.
    Zhang, Hong
    Högskolan i Skövde, Institutionen för vård och natur. Högskolan i Skövde, Forskningscentrum för Systembiologi.
    Adell, Gunnar
    Karolinska Univ Hosp, Dept Oncol, Stockholm, Sweden.
    Sun, Xiao-Feng
    Linkoping Univ, Inst Clin & Expt Med, Dept Oncol, S-58185 Linkoping, Sweden.
    Endosialin expression in relation to clinicopathological and biological variables in rectal cancers with a Swedish clinical trial of preoperative radiotherapy2011Ingår i: BMC Cancer, ISSN 1471-2407, E-ISSN 1471-2407, Vol. 11, s. Artikelnr 89-Artikel i tidskrift (Refereegranskat)
    Abstract [en]

    Background: The importance of changes in tumour-associated stroma for tumour initiation and progression has been established. Endosialin is expressed in fibroblasts and pericytes of blood vessels in several types of tumours, and is involved in the progression of colorectal cancer. In order to see whether endosialin was related to radiotherapy (RT) response, and clinicopathological and biological variables, we investigated endosialin expression in rectal cancers from the patients who participated in a Swedish clinical trial of preoperative RT. Methods: Endosialin was immunohistochemically examined in normal mucosa, including distant (n = 72) and adjacent (n = 112) normal mucosa, and primary tumours (n = 135). Seventy-three of 135 patients received surgery alone and 62 received additional preoperative RT. Results: Endosialin expression in the stroma increased from normal mucosa to tumour (p < 0.0001) both in RT and non-RT group. In the RT group, endosialin expression in the stroma was positively associated with expression of cyclooxygenase-2 (Cox-2) (p = 0.03), p73 (p = 0.01) and phosphates of regenerating liver (PRL) (p = 0.002). Endosialin expression in the tumour cells of both in the RT group (p = 0.01) and the non-RT group (p = 0.06) was observed more often in tumours with an infiltrative growth pattern than in tumours with an expansive growth pattern. In the RT group, endosialin expression in tumour cells was positively related to PRL expression (p = 0.02), whereas in the non-RT group, endosialin expression in tumour cells was positively related to p73 expression (p = 0.01). Conclusions: Endosialin expression may be involved in the progression of rectal cancers, and was related to Cox-2, p73 and PRL expression. However, a direct relationship between endosialin expression and RT responses in patients was not found.

  • 1204.
    Zichner, Thomas
    et al.
    Högskolan i Skövde, Forskningscentrum för Systembiologi. Högskolan i Skövde, Institutionen för vård och natur.
    Lubovac, Zelmina
    Högskolan i Skövde, Forskningscentrum för Systembiologi. Högskolan i Skövde, Institutionen för vård och natur.
    Olsson, Björn
    Högskolan i Skövde, Forskningscentrum för Systembiologi. Högskolan i Skövde, Institutionen för vård och natur.
    Temporal analysis of oncogenesis using microRNA expression data2008Ingår i: Proc. Ger. Conf. Bioinformatics, GCB, Bonn: Gesellschaft für Informatik , 2008, s. 128-137Konferensbidrag (Refereegranskat)
    Abstract [en]

    MicroRNAs (miRNAs) have rapidly become the focus of many cancer research studies. These small non-coding RNAs have been shown to play important roles in the regulation of oncogenes and tumor suppressors. It has also been demonstrated that miRNA expression profiles differ significantly between normal and cancerous cells, which indicates the possibility of using miRNAs as markers for cancer diagnosis and prognosis. However, not much is known about the regulation of miRNA expression. One of the issues worth investigating is whether deregulations of miRNA expression in cancer cells occur according to some pattern or in a random order. We therefore selected two approaches, previously used to derive graph models of oncogenesis using chromosomal imbalance data, and adapted them to miRNA expression data. Applying the adapted algorithms to a breast cancer data set, we obtained results indicating the temporal order of miRNA deregulations during tumor development. When analyzing the specific deregulations appearing at different time points in the derived model, we found that several of the deregulations identified as early events could be supported through literature studies.

  • 1205.
    Åberg, Cecilia
    Högskolan i Skövde, Institutionen för vård och natur.
    Att stödja föräldrar på Barnavårdscentralen (BVC): En kvalitativ intervjustudie om BVC-sjuksköterskors erfarenheter2010Självständigt arbete på avancerad nivå (magisterexamen), 10 poäng / 15 hpStudentuppsats (Examensarbete)
    Abstract [sv]

    Att bli förälder är en omtumlande upplevelse. För de föräldrar som vill ha stöd ska detta också finnas tillgängligt för att de med trygghet ska kunna möta barnets behov och stärka dess utveckling. BVC-sjuksköterskan har en central uppgift när det gäller att ge stöd till föräldrar med barn i åldrarna 0-6 år. Syftet med studien var att beskriva BVC-sjuksköterskors erfarenheter av att ge stöd i föräldraskapet. Metoden som användes var en kvalitativ innehållsanalys med induktiv ansats beskriven av Lundman och Hällgren Graneheim. Datainsamling gjordes genom intervjuer med fyra BVC-sjuksköterskor. Resultatet visade att BVC-sjuksköterskan upplevde att föräldrastöd var något som utfördes varje gång hon träffade föräldrarna. Genom att finnas till för familjen och stärka föräldrarnas egna resurser kunde hon stödja dem i föräldraskapet. Ett förändrat samhälle krävde dock en förändrad barnhälsovård och de resurser som gavs påverkade det stöd som kunde erbjudas föräldrarna.

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  • 1206. Ådin, Hanna
    et al.
    Ekstrand, Maria
    Hammarlund, Kina
    Högskolan i Skövde, Institutionen för vård och natur.
    Oskönt, krångligt, plastigt2009Ingår i: Insikt, ISSN 1104-0912, nr 4, s. 8-9Artikel i tidskrift (Övrig (populärvetenskap, debatt, mm))
  • 1207.
    Åström, Stina
    Högskolan i Skövde, Institutionen för vård och natur.
    Bränning som alternativ skötselmetodi gräsmarker2010Självständigt arbete på avancerad nivå (magisterexamen), 20 poäng / 30 hpStudentuppsats (Examensarbete)
    Abstract [sv]

    När storskaliga och kväveintensiva jordbruk bredde ut sig växte många betesmarker ochängar igen. Detta medförde att hävdberoende växtarter minskade eller helt försvann. Föratt kunna växa och återkolonisera marker behöver många arter olika störningar. En sådanstörning kan vara bränning. Vid bränning ökar ljusinsläppet och även kvävemängden imarken minskar, vilket gynnar de hävdberoende växterna.Detta arbete har undersökt om bränning kan vara ett komplement eller alternativ till beteoch slåtter vid bevarande av den biologiska mångfalden hos växter. I studien inventeradesbrända och orörda kontrollytor på 11 st olika gräsmarker i Östergötland. Dessagräsmarker inkluderar vägrenar, ängar, åkerslänter och naturbetesmarker.Tre olika diversitetsindex användes för att svara på om diversiteten var högre på brändamarkerna. Resultatet visade att diversiteten var högre och artfördelningen var jämnare påde brända ytorna än på kontrollytorna. De arter som är beroende av hävd hade en markantstörre utbredning på de brända markerna än på kontrollytorna. Detta bekräftar hypotesenom att bränning är positivt för hävdberoende växter och att bränning kan vara ettkomplement eller alternativ till bete och slåtter vid bevarande av den biologiskamångfalden av växter i gräsmarker. Den framtida skötseln skulle kunna vara olikakombinationer av bränningar, bete och slåtter.För naturvården kan detta konstaterande få betydelse genom att offentliga och privatamarkägare kan börja bränna fler områden med vetskapen att detta gynnar hävdberoendearter som är hotade. Att bränna marker istället för att slåttra eller beta kan leda till attstörre arealer kan få den skötsel de kräver utan förändringar i den finansiella budgetenhos markägaren.

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  • 1208.
    Öhlén, Joakim
    et al.
    Institute of Health Care Sciences, Sahlgrenska Academy at the University of Gothenburg, Sweden.
    Furåker, Carina
    Institute of Health Care Sciences, Sahlgrenska Academy at the University of Gothenburg, Sweden.
    Jakobsson, Eva
    Institute of Health Care Sciences, Sahlgrenska Academy at the University of Gothenburg, Sweden.
    Bergh, Ingrid
    Högskolan i Skövde, Institutionen för vård och natur.
    Hermansson, Evelyn
    Institute of Health Care Sciences, Sahlgrenska Academy at the University of Gothenburg, Sweden.
    Impact of the Bologna process in Bachelor nursing programmes: The Swedish case2011Ingår i: Nurse Education Today, ISSN 0260-6917, E-ISSN 1532-2793, Vol. 31, nr 2, s. 122-128Artikel i tidskrift (Refereegranskat)
    Abstract [en]

    The higher education reform in Europe known as the “Bologna Process” implies further harmonisation and integration of nursing programmes into the higher education system. This study explores this process in Sweden, where the development of nursing education into an undergraduate programme started in 1977. The aim of this study was to analyse characteristics of the major subject and its relationship to other subject areas, such as medical sciences and social sciences, in Bachelor level nursing programmes in Sweden following initial implementation of the Bologna process. A constructivist approach and descriptive content analysis were employed to analyse the 2008 nursing curricula and syllabi of 27 undergraduate programmes at 26 Swedish universities and university colleges. The results revealed variation in terms and concepts used for the major subject as well as its scientific foundation, demarcation between the major subject and other subjects included in the study programmes and its relationship to the profession. These variations are linked to the variety of research orientations under debate in the Scandinavian countries: Nursing Science and Caring Science; representing different knowledge domains, focus, challenges and visions for the discipline. Potential implications of basing curricula on a major subject other than Nursing Science in a Bachelor level nursing programme are highlighted.

  • 1209.
    Östensson, Malin
    et al.
    Department of Mathematical Sciences, Chalmers University of Technology, Gothenburg, Sweden.
    Montén, Caroline
    Diabetes and Celiac Disease Unit, Department of Clinical Sciences, Lund University, Malmö, Sweden.
    Bacelis, Jonas
    Institute of Biomedicine, Department of Medical and Clinical Genetics, Sahlgrenska Academy at the University of Gothenburg, Gothenburg, Sweden.
    Gudjonsdottir, Audur H.
    Queen Silvia Children’s Hospital, Sahlgrenska Academy at the University of Gothenburg, Department of Pediatrics, Gothenburg, Sweden.
    Adamovic, Svetlana
    Institute of Biomedicine, Department of Medical and Clinical Genetics, Sahlgrenska Academy at the University of Gothenburg, Gothenburg, Sweden.
    Ek, Johan
    Buskerud Central Hospital, Department of Pediatrics, Drammen, Norway.
    Ascher, Henry
    Sahlgrenska Academy at the University of Gothenburg, Department of Public Health and Community Medicine, Unit of Social Medicine, Gothenburg, Sweden.
    Pollak, Elisabet
    Institute of Biomedicine, Department of Medical and Clinical Genetics, Sahlgrenska Academy at the University of Gothenburg, Gothenburg, Sweden.
    Arnell, Henrik
    Department of Pediatric Gastroenterology, Hepatology and Nutrition, Karolinska University Hospital and Division of Pediatrics, CLINTEC, Karolinska Institutet, Stockholm, Sweden.
    Browaldh, Lars
    Department of Clinical Science and Education, Karolinska Institutet Södersjukhuset, Stockholm, Sweden.
    Agardh, Daniel
    Diabetes and Celiac Disease Unit, Department of Clinical Sciences, Lund University, Malmö, Sweden.
    Wahlström, Jan
    Institute of Biomedicine, Department of Medical and Clinical Genetics, Sahlgrenska Academy at the University of Gothenburg, Gothenburg, Sweden.
    Nilsson, Staffan
    Department of Mathematical Sciences, Chalmers University of Technology, Gothenburg, Sweden.
    Torinsson-Naluai, Åsa
    Högskolan i Skövde, Institutionen för vård och natur. Högskolan i Skövde, Forskningscentrum för Systembiologi. Institute of Biomedicine, Department of Medical and Clinical Genetics, Sahlgrenska Academy at the University of Gothenburg, Gothenburg, Sweden.
    A Possible Mechanism behind Autoimmune Disorders Discovered By Genome-Wide Linkage and Association Analysis in Celiac Disease2013Ingår i: PLoS ONE, ISSN 1932-6203, E-ISSN 1932-6203, Vol. 8, nr 8, artikel-id e70174Artikel i tidskrift (Refereegranskat)
    Abstract [en]

    Celiac disease is a common autoimmune disorder characterized by an intestinal inflammation triggered by gluten, a storage protein found in wheat, rye and barley. Similar to other autoimmune diseases such as type 1 diabetes, psoriasis and rheumatoid arthritis, celiac disease is the result of an immune response to self-antigens leading to tissue destruction and production of autoantibodies. Common diseases like celiac disease have a complex pattern of inheritance with inputs from both environmental as well as additive and non-additive genetic factors. In the past few years, Genome Wide Association Studies (GWAS) have been successful in finding genetic risk variants behind many common diseases and traits. To complement and add to the previous findings, we performed a GWAS including 206 trios from 97 nuclear Swedish and Norwegian families affected with celiac disease. By stratifying for HLA-DQ, we identified a new genome-wide significant risk locus covering the DUSP10 gene. To further investigate the associations from the GWAS we performed pathway analyses and two-locus interaction analyses. These analyses showed an over-representation of genes involved in type 2 diabetes and identified a set of candidate mechanisms and genes of which some were selected for mRNA expression analysis using small intestinal biopsies from 98 patients. Several genes were expressed differently in the small intestinal mucosa from patients with celiac autoimmunity compared to intestinal mucosa from control patients. From top-scoring regions we identified susceptibility genes in several categories: 1) polarity and epithelial cell functionality; 2) intestinal smooth muscle; 3) growth and energy homeostasis, including proline and glutamine metabolism; and finally 4) innate and adaptive immune system. These genes and pathways, including specific functions of DUSP10, together reveal a new potential biological mechanism that could influence the genesis of celiac disease, and possibly also other chronic disorders with an inflammatory component.

  • 1210.
    Österberg, Lovisa
    et al.
    University of Gothenburg.
    Levan, Kristina
    University of Gothenburg.
    Partheen, Karolina
    University of Gothenburg.
    Dalle, Ulla
    University of Gothenburg.
    Olsson, Björn
    Högskolan i Skövde, Forskningscentrum för Systembiologi. Högskolan i Skövde, Institutionen för vård och natur.
    Sundfeldt, Karin
    University of Gothenburg.
    Horvath, György
    University of Gothenburg.
    Specific Copy Number Alterations Associated with Docetaxel/Carboplatin Response in Ovarian Carcinomas2010Ingår i: Anticancer Research, ISSN 0250-7005, E-ISSN 1791-7530, Vol. 30, nr 11, s. 4451-4458Artikel i tidskrift (Refereegranskat)
    Abstract [en]

    Background: The continued high recurrence and mortality rate in ovarian cancer is a significant problem and the major obstacle in the treatment of ovarian cancer patients is chemotherapy resistance. Thus, finding predictive markers of chemoresistance and elucidating resistance mechanisms is crucial for individualising treatment and improving survival of ovarian cancer patients. Materials and Methods: Using array comparative genomic hybridisation (CGH), this pilot study analysed the tumour genomes of patients treated with docetaxel/carboplatin as first-line chemotherapy (6 resistant versus 24 sensitive cases). This is the first array CGH study of  such  material.  Results:  The  study  identified  genetic alterations specific to chemoresistant (gains in 9p13.2-13.1, 9q21.2-21.32,  9q21.33,  9q22.2-22.31,  9q22.32-22.33  and 9q33.1-34.11) and chemosensitive (losses in 8p23.3-23.1 and 8p22) disease. Additionally, when comparing the results to previously analysed tumour material from patients treated with paclitaxel/carboplatin, the two datasets identified different genetic  alteration  profiles.  Conclusion:  Specific  genetic alterations were identified and associated with chemotherapy response in ovarian cancer. It will be interesting to investigate these exciting data further in larger independent series of ovarian   tumours,   and   hopefully   will   contribute   to   the establishment of predictive markers.

  • 1211.
    Österberg, Lovisa
    et al.
    University of Gothenburg.
    Levan, Kristina
    University of Gothenburg.
    Partheen, Karolina
    University of Gothenburg.
    Delle, Ulla
    University of Gothenburg.
    Olsson, Björn
    Högskolan i Skövde, Forskningscentrum för Systembiologi. Högskolan i Skövde, Institutionen för vård och natur.
    Horvath, Karin
    University of Gothenburg.
    Potential predictive markers of chemotherapy resistance ovarian serous carcinomas2009Ingår i: BMC Cancer, ISSN 1471-2407, E-ISSN 1471-2407, Vol. 9, s. 368-Artikel i tidskrift (Refereegranskat)
    Abstract [en]

    Background Chemotherapy resistance remains a major obstacle in the treatment of women with ovarian cancer. Establishing predictive markers of chemoresponse would help to individualize therapy and improve survival of ovarian cancer patients. Chemotherapy resistance in ovarian cancer has been studied thoroughly and several non-overlapping single genes, gene profiles and copy number alterations have been suggested as potential markers. The objective of this study was to explore genetic alterations behind chemotherapy resistance in ovarian cancer with the ultimate aim to find potential predictive markers.

    Methods To create the best opportunities for identifying genetic alterations of importance for resistance, we selected a homogenous tumor material concerning histology, stage and chemotherapy. Using high-resolution whole genome array comparative genomic hybridization (CGH), we analyzed the tumor genomes of 40 fresh-frozen stage III ovarian serous carcinomas, all uniformly treated with combination therapy paclitaxel/carboplatin. Fisher's exact test was used to identify significant differences. Subsequently, we examined four genes in the significant regions (EVI1, MDS1, SH3GL2, SH3KBP1) plus the ABCB1 gene with quantitative real-time polymerase chain reaction (QPCR) to evaluate the impact of DNA alterations on the transcriptional level.

    Results We identified gain in 3q26.2, and losses in 6q11.2-12, 9p22.3, 9p22.2-22.1, 9p22.1-21.3, Xp22.2-22.12, Xp22.11-11.3, and Xp11.23-11.1 to be significantly associated with chemotherapy resistance. In the gene expression analysis, EVI1 expression differed between samples with gain versus without gain, exhibiting higher expression in the gain group.

    Conclusion In conclusion, we detected specific genetic alterations associated with resistance, of which some might be potential predictive markers of chemotherapy resistance in advanced ovarian serous carcinomas. Thus, further studies are required to validate these findings in an independent ovarian tumor series.

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  • 1212.
    Özdogan, Alper
    Högskolan i Skövde, Institutionen för vård och natur.
    Clustering Genes by Using Different Types of Genomic Data and Self-Organizing Maps2008Självständigt arbete på avancerad nivå (magisterexamen), 10 poäng / 15 hpStudentuppsats
    Abstract [en]

    The aim of the project was to identify biologically relevant novel gene clusters by using combined genomic data instead of using only gene expression data in isolation. The clustering algorithm based on self-organizing maps (Kasturi et al., 2005) was extended and implemented in order to use gene location data together with the gene expression and the motif occurrence data for gene clustering. A distance function was defined to be used with gene location data. The algorithm was also extended in order to use vector angle distance for gene expression data. Arabidopsis thaliana is chosen as a data source to evaluate the developed algorithm. A test data set was created by using 100 Arabidopsis genes that have gene expression data with seven different time points during cold stress condition, motif occurrence data which indicates the occurrence frequency of 614 different motifs and the chromosomal location data of each gene. Gene Ontology (http://www.geneontology.org) and TAIR (http://arabidopsis.org) databases were used to find the molecular function and biological process information of each gene in order to examine the biological accuracy of newly discovered clusters after using combined genomic data. The biological evaluation of the results showed that using combined genomic data to cluster genes resulted in new biologically relevant clusters.

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