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  • 1.
    Claesson, Jan-Eric
    University of Skövde, School of Life Sciences.
    Induced cardioinhibitory carotid sinus syndrome: Studies on syncope or pre-syncope and health-related quality of life in patients with or without a permanent pacemaker2011Licentiate thesis, comprehensive summary (Other academic)
  • 2.
    Claesson, Jan-Eric
    et al.
    University of Skövde, School of Life Sciences.
    Kristensson, Bo-Erik
    Cent Hosp Skövde, Dept Cardiol, Skövde, Sweden.
    Edvardsson, Nils
    Sahlgrens Univ Hosp, Div Cardiol, Gothenburg, Sweden.
    Währborg, Peter
    Univ Gothenburg, Sahlgrenska Acad, Inst Med, Gothenburg, Sweden.
    Less syncope and milder symptoms in patients treated with pacing for induced cardioinhibitory carotid sinus syndrome: a randomized study2007In: Europace, ISSN 1099-5129, E-ISSN 1532-2092, Vol. 9, no 10, p. 932-936Article in journal (Refereed)
    Abstract [en]

    Aims The aim of this study was to examine the effect on symptoms in patients with induced cardioinhibitory carotid sinus syndrome (ICSS) when treated or not treated with a pacemaker.

    Methods and results Sixty patients with a history of syncope or pre-syncope and ICSS were randomized to receive a permanent pacemaker (P group, n = 30) or no pacing (NP group, n = 30). ICSS was defined as a ventricular pause (i.e. asystole) lasting 3 s or more in response to carotid sinus stimulation. The patients were seen at 3 and 12 months and at symptoms. At 12 months, the rate of syncope in the NP group was 40% (n = 12) compared with 10% (n = 3) in the P group (P = 0.008). The majority (11 of 12) of the syncope recurrences in the NP group occurred during the first 3 months. Pre-syncope occurred in two patients (7%) in the NP group and in eight (27%) in the P group. Ten patients (33%) with recurrent syncope in the NP group later crossed-over to receive pacemaker implant.

    Conclusions A history of syncope or pre-syncope, plus ICSS, was a strong predictor of subsequent syncope or pre-syncope. Most of the new symptoms occurred within 3 months. Pacemaker treatment effectively reduced syncope and/or resulted in milder symptoms.

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