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  • 1.
    Ericson, Henrik
    et al.
    University of Skövde, The Systems Biology Research Centre. University of Skövde, School of Life Sciences.
    Fagerlind, Magnus
    University of Skövde, The Systems Biology Research Centre. University of Skövde, School of Life Sciences.
    Incorporating Sunflower for Science in teacher education to increase the pedagogical information technology competence of teachers and teacher students in natural science2010In: Society for Information Technology & Teacher Education, 21st International Conference, March 29 - April 2, 2010, Sand Diego, California, USA / [ed] Gibson, D. & Dodge, B., Association for the Advancement of Computing in Education, 2010, p. 463-468Conference paper (Refereed)
    Abstract [en]

    The use of information and communication technology in teaching is an excellent way to visualize processes as well as promote active learning in natural science, hence providing an additional dimension in teaching. KompLIT (Competence Enhancement of Teacher Education Information Technology) is a Swedish project that aims to increase the competence in pedagogical information technology for both teachers and teacher students. As part of this project the software Sunflower for Science has been tested and evaluated by both teachers and teacher students. Sunflower for Science consists of 26 programs in physics, chemistry and biology and uses an interactive approach that engages students with an activity-based learning. The outcome from the evaluation is that Sunflower for Science is very user-friendly, it promotes deeper learning as well as increases the students’ attitude towards chemistry.

  • 2.
    Fagerlind, Magnus G.
    et al.
    University of Skövde, School of Life Sciences. University of Skövde, The Systems Biology Research Centre.
    Webb, Jeremy S.
    Univ Southampton, Sch Biol Sci, Southampton SO16 7PX, Hants, England .
    Barraud, Nicolas
    Univ New S Wales, Ctr Marine Bioinnovat, Sydney, NSW 2052, Australia / Univ New S Wales, Sch Biotechnol & Biomol Sci, Sydney, NSW 2052, Australia .
    McDougald, Diane
    Univ New S Wales, Ctr Marine Bioinnovat, Sydney, NSW 2052, Australia / Univ New S Wales, Sch Biotechnol & Biomol Sci, Sydney, NSW 2052, Australia / Nanyang Technol Univ, Adv Environm Biotechnol Ctr, Singapore 639798, Singapore .
    Jansson, Andreas
    University of Skövde, School of Life Sciences. University of Skövde, The Systems Biology Research Centre.
    Nilsson, Patric
    University of Skövde, School of Life Sciences. University of Skövde, The Systems Biology Research Centre.
    Harlen, Mikael
    University of Skövde, School of Life Sciences. University of Skövde, The Systems Biology Research Centre.
    Kjelleberg, Staffan
    Univ New S Wales, Ctr Marine Bioinnovat, Sydney, NSW 2052, Australia / Univ New S Wales, Sch Biotechnol & Biomol Sci, Sydney, NSW 2052, Australia / Nanyang Technol Univ, Singapore Ctr Environm Life Sci Engn, Singapore 639798, Singapore .
    Rice, Scott A.
    Univ New S Wales, Ctr Marine Bioinnovat, Sydney, NSW 2052, Australia / Univ New S Wales, Sch Biotechnol & Biomol Sci, Sydney, NSW 2052, Australia / Nanyang Technol Univ, Singapore Ctr Environm Life Sci Engn, Singapore 639798, Singapore .
    Dynamic modelling of cell death during biofilm development2012In: Journal of Theoretical Biology, ISSN 0022-5193, E-ISSN 1095-8541, Vol. 295, p. 23-36Article in journal (Refereed)
    Abstract [en]

    Biofilms are currently recognised as the predominant bacterial life-style and it has been suggested that biofilm development is influenced by a number of different processes such as adhesion, detachment, mass transport, quorum sensing, cell death and active dispersal. One of the least understood processes and its effects on biofilm development is cell death. However, experimental studies suggest that bacterial death is an important process during biofilm development and many studies show a relationship between cell death and dispersal in microbial biofilms. We present a model of the process of cell death during biofilm development, with a particular focus on the spatial localisation of cell death or cell damage. Three rules governing cell death or cell damage were evaluated which compared the effects of starvation, damage accumulation, and viability during biofilm development and were also used to design laboratory based experiments to test the model. Results from model simulations show that actively growing biofilms develop steep nutrient gradients within the interior of the biofilm that affect neighbouring microcolonies resulting in cell death and detachment. Two of the rules indicated that high substrate concentrations lead to accelerated cell death, in contrast to the third rule, based on the accumulation of damage, which predicted earlier cell death for biofilms grown with low substrate concentrations. Comparison of the modelling results with experimental results suggests that cell death is favoured under low nutrient conditions and that the accumulation of damage may be the main cause of cell death during biofilm development. (C) 2011 Elsevier Ltd. All rights reserved.

  • 3.
    Fagerlind, Magnus
    et al.
    University of Skövde, School of Life Sciences.
    Nilsson, Patric
    University of Skövde, School of Life Sciences.
    Harlén, Mikael
    University of Skövde, School of Life Sciences.
    Karlsson, Sandra
    University of Skövde, School of Life Sciences.
    Rice, Scott A.
    Sch. of Biotech. and Biomol. Sci., University of New South Wales, Sydney, NSW 2052, Australia / Ctr. Mar. Biofouling and Bio-Innov., University of New South Wales, Sydney, NSW 2052, Australia.
    Kjelleberg, Staffan
    Sch. of Biotech. and Biomol. Sci., University of New South Wales, Sydney, NSW 2052, Australia / Ctr. Mar. Biofouling and Bio-Innov., University of New South Wales, Sydney, NSW 2052, Australia.
    Modeling the effect of acylated homoserine lactone antagonists in Pseudomonas aeruginosa2005In: Biosystems (Amsterdam. Print), ISSN 0303-2647, E-ISSN 1872-8324, Vol. 80, no 2, p. 201-213Article in journal (Refereed)
    Abstract [en]

    Pseudomonas aeruginosa is a gram-negative bacterium that causes serious illnesses, particularly in immunocompromised individuals, often with a fatal outcome. The finding that the acylated homoserine lactone quorum sensing (QS) system controls the production of virulence factors in P. aeruginosa makes this system a possible target for antimicrobial therapy. It has been suggested that an N-(3-oxododecanoyl)-homoserine lactone (3O-C12-HSL) antagonist, a QS blocker (QSB), would interfere efficiently with the quorum sensing system in P. aeruginosa and thus reduce the virulence of this pathogen. In this work, a mathematical model of the QS system in P. aeruginosa has been developed. The model was used to virtually add 3O-C12-HSL antagonists that differed in their affinity for the receptor protein and for their ability to mediate degradation of the receptor. The model suggests that very small differences in these parameters for different 3O-C12-HSL antagonists can greatly affect the success of QSB based inhibition of the QS system in P. aeruginosa. Most importantly, it is proposed that the ability of the 3O-C12-HSL antagonist to mediate degradation of LasR is the core parameter for successful QSB based inhibition of the QS system in P. aeruginosa. Finally, this study demonstrates that QSBs can shift the system to a low steady state, corresponding to an uninduced state and thus, suggests that the use of 3O-C12-HSL antagonists may constitute a promising therapeutic approach against P. aeruginosa involved infections.

  • 4.
    Fagerlind, Magnus
    et al.
    University of Skövde, School of Life Sciences. The School of Biotechnology and Biomolecular Sciences, The University of New South Wales, Sydney, Australia.
    Rice, Scott A.
    The School of Biotechnology and Biomolecular Sciences, and The Center for Marine Biofouling and Bio-Innovation, The University of New South Wales, Sydney, Australia.
    Nilsson, Patric
    University of Skövde, School of Life Sciences.
    Harlén, Mikael
    University of Skövde, School of Life Sciences.
    James, Sally
    The School of Biotechnology and Biomolecular Sciences, The University of New South Wales, Sydney, Australia.
    Charlton, Timothy
    The School of Biotechnology and Biomolecular Sciences, and The Center for Marine Biofouling and Bio-Innovation, The University of New South Wales, Sydney, Australia.
    Kjelleberg, Staffan
    The School of Biotechnology and Biomolecular Sciences, and The Center for Marine Biofouling and Bio-Innovation, The University of New South Wales, Sydney, Australia.
    The Role of Regulators in the Expression of Quorum-Sensing Signals in Pseudomonas aeruginosa2003In: Journal of Molecular Microbiology and Biotechnology, ISSN 1464-1801, Vol. 6, no 2, p. 88-100Article in journal (Refereed)
    Abstract [en]

    Quorum-sensing systems provide Pseudomonas aeruginosa with a sensitive regulatory mechanism that allows for the induction of several phenotypic genes in a cell density fashion. In this work, a mathematical model of the acylated homoserine lactones regulatory network system in P. aeruginosa has been developed. It is the first integrated model to consider both quorum-sensing systems. The model has allowed us to disentangle the complex behavior exhibited by the system as the concentration of extracellular OdDHL is increased. At either low or high levels of extracellular OdDHL, the bacterium remains in an uninduced or induced state, respectively. At moderate levels, the behavior is characterized by several states. Here, the bacteria can switch suddenly from an uninduced to an induced phenotype in response to small changes in the concentration of extracellular OdDHL. Additionally, we have been able to address the roles of RsaL and Vfr as regulators of the quorum-sensing system. An important result from this analysis suggests that RsaL will increase the concentration of extracellular OdDHL required to induce the system, and it is a key regulator of the inhibition of the quorum-sensing system under low cell densities. Most importantly, our results suggest that Vfr has strong regulatory effects on the system as an increased affinity between the LasR/OdDHL complex, and the lasR promoter leads to significant qualitative changes in induction patterns. We also show experimental data that demonstrate that Vfr is required for signal production in the early phase of growth, but that in the latter stages of growth, the vfr mutant is able to synthesize wild-type levels of signal.

  • 5.
    Fagerlind, Magnus
    et al.
    University of Skövde, The Systems Biology Research Centre. University of Skövde, School of Bioscience.
    Stålhammar, Hans
    VikingGenetics, Skara.
    Olsson, Björn
    University of Skövde, The Systems Biology Research Centre. University of Skövde, School of Bioscience.
    Klinga-Levan, Karin
    University of Skövde, The Systems Biology Research Centre. University of Skövde, School of Bioscience.
    Expression of miRNAs in Bull Spermatozoa Correlates with Fertility Rates2015In: Reproduction in domestic animals, ISSN 0936-6768, E-ISSN 1439-0531, Vol. 50, no 4, p. 587-594Article in journal (Refereed)
  • 6.
    Jansson, Andreas
    et al.
    University of Skövde, School of Life Sciences.
    Fagerlind, Magnus
    University of Skövde, School of Life Sciences.
    Karlsson, Diana
    University of Skövde, School of Life Sciences.
    Nilsson, Patric
    University of Skövde, School of Life Sciences.
    Cooley, Margaret
    School of Biotechnology and Biomolecular Sciences, University of New South Wales, Sydney, NSW, Australia.
    In silico simulations suggest that Th-cell development is regulated by both selective and instructive mechanisms2006In: Immunology and Cell Biology, ISSN 0818-9641, E-ISSN 1440-1711, Vol. 84, no 2, p. 218-226Article in journal (Refereed)
    Abstract [en]

    Th-cell differentiation is highly influenced by the local cytokine environment. Although cytokines such as IL-12 and IL-4 are known to polarize the Th-cell response towards Th1 or Th2, respectively, it is not known whether these cytokines instruct the developmental fate of uncommitted Th cells or select cells that have already been committed through a stochastic process. We present an individual based model that accommodates both stochastic and deterministic processes to simulate the dynamic behaviour of selective versus instructive Th-cell development. The predictions made by each model show distinct behaviours, which are compared with experimental observations. The simulations show that the instructive model generates an exclusive Th1 or Th2 response in the absence of an external cytokine source, whereas the selective model favours coexistence of the phenotypes. A hybrid model, including both instructive and selective development, shows behaviour similar to either the selective or the instructive model dependent on the strength of activation. The hybrid model shows the closest qualitative agreement with a number of well-established experimental observations. The predictions by each model suggest that neither pure selective nor instructive Th development is likely to be functional as exclusive mechanisms in Th1/Th2 development.

1 - 6 of 6
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