The Health Care Nurse plays an important role in motivating patients to implement lifestyle changes. Unhealthiness causes risks of developing long-lasting diseases and other complications. Living conditions and living habits are of great significance in terms of human health. Lifestyle changes, in contrast to drugs, often have an impact on both risk markers and states of diseases. The purpose of this study was to describe district nurses’ experiences when motivating patients to take part in health-promoting lifestyle changes. The study is based on a qualitative method with an inductive approach. Through interviews, data was collected from six health care nurses and analyzed using a qualitative content analysis. The results are based on two categories, quality of the professional support together with evidence and experiences important to the changing process. These categories formed the theme: Health Care Nurses´, sensitivity and knowledge are the guiding principles in terms of motivating patients to pursue a healthier lifestyle. The results of our study show that it is important to listen and to acknowledge the patient to be able to support them emotionally. Undergoing lifestyle changes require explanation and information. The changing process requires tools, the informants must have a reflective attitude to be able to work based on evidence. The patient needs to realize the importance of making a lifestyle change and also be prepared to take the losses. When doing so the patients will learn that they gain more than they lose.