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  • 1.
    Wolters, Maike
    et al.
    Leibniz Inst Prevent Res & Epidemiol BIPS, Bremen, Germany.
    Boernhorst, Claudia
    Leibniz Inst Prevent Res & Epidemiol BIPS, Bremen, Germany.
    Schwarz, Heike
    Leibniz Inst Prevent Res & Epidemiol BIPS, Bremen, Germany.
    Rise, Patrizia
    Univ Milan, Dept Pharmacol & Biomol Sci, DiSFeB, Milan, Italy.
    Galli, Claudio
    Univ Milan, Dept Pharmacol & Biomol Sci, DiSFeB, Milan, Italy.
    Moreno, Luis A.
    Univ Zaragoza, Growth Exercise Nutr & Dev GENUD Res Grp, Zaragoza, Spain.
    Pala, Valeria
    Fdn IRCCS Ist Nazl Tumori, Dept Prevent & Predict Med, Epidemiol & Prevent Unit, Milan, Italy.
    Russo, Paola
    CNR, Inst Food Sci, Epidemiol & Populat Genet, Avellino, Italy.
    Veidebaum, Toomas
    Natl Inst Hlth Dev, Tallinn, Estonia.
    Tornaritis, Michael
    Res & Educ Inst Child Hlth, Strovolos, Cyprus.
    Fraterman, Arno
    Med Versorgungszentrum Dr Eberhard & Partner Dort, Lab Med, Dortmund, Germany.
    De Henauw, Stefaan
    Univ Ghent, Fac Med & Hlth Sci, Dept Publ Hlth, Ghent, Belgium.
    Eiben, Gabriele
    Univ Gothenburg, Sahlgrenska Acad, Inst Med, Sect Epidemiol & Social Med, Gothenburg, Sweden.
    Lissner, Lauren
    Univ Gothenburg, Sahlgrenska Acad, Inst Med, Sect Epidemiol & Social Med, Gothenburg, Sweden.
    Molnar, Denes
    Univ Pecs, Natl Inst Hlth Promot, Pecs, Hungary.
    Ahrens, Wolfgang
    Leibniz Inst Prevent Res & Epidemiol BIPS, Bremen, Germany.;Univ Bremen, Inst Stat, Fac Math & Comp Sci, Bremen, Germany.
    Association of desaturase activity and C-reactive protein in European children2017In: Pediatric Research, ISSN 0031-3998, E-ISSN 1530-0447, Vol. 81, no 1, p. 27-32Article in journal (Refereed)
    Abstract [en]

    BACKGROUND: Desaturase enzymes influence the fatty acid (FA) composition of body tissues and their activity affects the conversion rate of saturated to monounsaturated FA and of polyunsaturated FA (PUFA) to long-chain PUFA. Desaturase activity has further been shown to be associated with inflammation. We investigate the association between delta-9 (D9D), delta-6 (D6D) and delta-5 desaturase (D5D) activity and high sensitive C-reactive protein (CRP) in young children. METHODS: In the IDEFICS (Identification and prevention of dietary- and lifestyle-induced health effects in children and infants) cohort study children were examined at baseline (TO) and after 2 y (T1). D9D, D6D, and D5D activities were estimated from TO product-precursor FA ratios. CRP was measured at TO and T1. In a subsample of 1,943 children with available information on FA, CRP, and covariates, the cross-sectional and longitudinal associations of desaturase activity and CRP were analyzed. RESULTS: Cross-sectionally, a D9D increase of 0.01 units was associated with a 11% higher risk of having a serum CRP Percentile 75 (P75) (OR, 99% CI: 1.11 (1.01; 1.22)) whereas D6D and D5D were not associated with CRP. No significant associations were observed between baseline desaturase activity and CRP 2 y later. CONCLUSION: Cross-sectionally, our results indicate a positive association of D9D and CRP independent of weight status. High D9D activity may increase the risk of subclinical inflammation which is associated with metabolic disorders. As D9D expression increases with higher intake of saturated FA and carbohydrates, dietary changes may influence D9D activity and thus CRP. However, it remains to be investigated whether there is a causal relationship between D9D activity and CRP.

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