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  • 1.
    Linde, Mattias
    et al.
    Cephalea Headache Centre, Gothenburg / Institute of Neuroscience and Physiology, University of Gothenburg, Gothenburg, Sweden.
    Jonsson, Pernilla
    Department of Public Health and Community Medicine, The Sahlgrenska Academy, University of Gothenburg, Gothenburg, Sweden.
    Hedenrud, Tove
    Department of Public Health and Community Medicine, The Sahlgrenska Academy, University of Gothenburg, Gothenburg, Sweden.
    Influence of disease features on adherence to prophylactic migraine medication2008In: Acta Neurologica Scandinavica, ISSN 0001-6314, E-ISSN 1600-0404, Vol. 118, no 6, p. 367-372Article in journal (Refereed)
    Abstract [en]

    OBJECTIVES: Randomized controlled trials of prophylactic treatments for migraine focus on the effects in an ideal situation and underestimate the impact of non-adherence, which in this study was examined in a natural setting.

    MATERIALS AND METHODS: A sample of 174 adult migraineurs with a current prescription of pharmacological prophylaxis were consecutively recruited at a specialist clinic. Logistic regression analysis was performed to analyse the association between adherence (self-reported with the Medication Adherence Report Scale) and number of years with migraine, frequency of attacks, number of days with migraine per month, attack duration, presence of cardinal features, mean intensity of pain, and recovery between attacks.

    RESULTS: One third (35%) were non-adherent. Neither demographic characteristics nor any of the disease specific variables were significantly associated with adherence.

    CONCLUSION: Characteristics of the disease per se did not predict non-adherence which was also observed among patients with severe migraine. The full benefit of drugs cannot be realized at currently achieved levels of adherence.

  • 2.
    Sunnerhagen, Katharina S.
    et al.
    Department of Clinical Neuroscience-Rehabilitation Medicine, University of Göteborg, Sahlgrenska Hospital, Göteborg, Sweden.
    Darin, N.
    Department of Pediatrics, Sahlgrenska Academy, Göteborg University, Göteborg, Sweden.
    Tajsharghi, Homa
    Department of Pathology, Sahlgrenska Academy, Göteborg University, Göteborg, Sweden.
    Oldfors, Anders
    Department of Pathology, Sahlgrenska Academy, Göteborg University, Göteborg, Sweden.
    The effects of endurance training in persons with a hereditary myosin myopathy2004In: Acta Neurologica Scandinavica, ISSN 0001-6314, E-ISSN 1600-0404, Vol. 110, no 2, p. 80-86Article in journal (Refereed)
    Abstract [en]

    OBJECTIVE: To evaluate muscle performance and its consequences in eight individuals with a hereditary myopathy and the effects of an 8-week endurance training program.

    MATERIAL AND METHODS: Handgrip, muscle strength and endurance and oxygen consumption by breath-by-breath analysis during a stepless bicycle ergonometer test were evaluated. Walking, balance test and activities of daily living (ADL) were assessed, and a questionnaire for activity level and perceived symptoms was used. The design was a before-after trial in comparison with data from a control population, bicycling at 70% of maximal workload, 30 min/day, 5 days/week for 8 weeks.

    RESULTS: The subjects were weaker than age-matched controls. After training, the peak watt increased by almost 20% (P < 0.05). Muscle strength (flexion/extension) and isometric endurance (40% of maximum at 60 degrees ) did not change significantly. The average self-selected walking speed increased significantly (P < 0.05) from 1.25 to 1.45 m/s. Compliance was excellent and no serious adverse events occurred.

    CONCLUSION: Endurance training seems to function for this myopathy.

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