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  • 1.
    Abulafia, Carolina
    et al.
    FLENI Foundation Department of Psychiatry, Buenos Aires, Argentina / Applied Neuroscience Laboratory, Institute for Biomedical Research, School of Medical Sciences, Universidad Católica Argentina, Buenos Aires, Argentina / Consejo Nacional de Investigaciones Científicas y Técnicas, Buenos Aires, Argentina.
    Duarte-Abritta, Bárbara
    FLENI Foundation Department of Psychiatry, Buenos Aires, Argentina.
    Villarreal, Mirta F.
    FLENI Foundation Department of Psychiatry, Buenos Aires, Argentina / Consejo Nacional de Investigaciones Científicas y Técnicas, Buenos Aires, Argentina.
    Ladrón-de-Guevara, Maria S.
    FLENI Foundation Department of Psychiatry, Buenos Aires, Argentina / Consejo Nacional de Investigaciones Científicas y Técnicas, Buenos Aires, Argentina.
    Garcia, Celeste
    FLENI Foundation Department of Psychiatry, Buenos Aires, Argentina.
    Sequeyra, Geraldine
    FLENI Foundation Department of Psychiatry, Buenos Aires, Argentina.
    Sevlever, Gustavo
    FLENI Foundation Department of Psychiatry, Buenos Aires, Argentina.
    Fiorentini, Leticia
    FLENI Foundation Department of Psychiatry, Buenos Aires, Argentina.
    Bär, Karl-Jürgen
    Department of Psychiatry and Psychotherapy, Universitätsklinikum Jena, Friedrich-Schiller-Universität, Jena, Germany.
    Gustafson, Deborah R.
    University of Skövde, School of Health and Education. University of Skövde, Health and Education. Department of Neurology, State University of New York, Downstate Medical Center, Brooklyn, NY, USA / Neuropsychiatric Epidemiology Unit, University of Gothenburg, Gothenburg, Sweden.
    Vigo, Daniel E.
    Applied Neuroscience Laboratory, Institute for Biomedical Research, School of Medical Sciences, Universidad Católica Argentina, Buenos Aires, Argentina / Consejo Nacional de Investigaciones Científicas y Técnicas, Buenos Aires, Argentina.
    Guinjoan, Salvador M.
    FLENI Foundation Department of Psychiatry, Buenos Aires, Argentina / Consejo Nacional de Investigaciones Científicas y Técnicas, Buenos Aires, Argentina / FLENI Teaching Unit, Department of Psychiatry and Mental Health, University of Buenos Aires School of Medicine, Buenos Aires, Argentina / Department of Neurophysiology, University of Buenos Aires School of Psychology, Buenos Aires, Argentina.
    Relationship between Cognitive and Sleep-wake Variables in Asymptomatic Offspring of Patients with Late-onset Alzheimer's Disease2017In: Frontiers in Aging Neuroscience, ISSN 1663-4365, E-ISSN 1663-4365, Vol. 9, article id 93Article in journal (Refereed)
    Abstract [en]

    Early neuropathological changes characteristic of late-onset Alzheimer's disease (LOAD) involve brain stem and limbic structures that regulate neurovegetative functions, including sleep-wake rhythm. Indeed, sleep pattern is an emerging biomarker and a potential pathophysiological mechanism in LOAD. We hypothesized that cognitively asymptomatic, middle-aged offspring of patients with LOAD (O-LOAD) would display a series of circadian rhythm abnormalities prior to the onset of objective cognitive alterations. We tested 31 children of patients with LOAD (O-LOAD) and 19 healthy individuals without family history of Alzheimer's disease (control subjects, CS) with basic tests of cognitive function, as well as actigraphy measures of sleep-wake rhythm, cardiac autonomic function, and bodily temperature. Unexpectedly, O-LOAD displayed subtle but significant deficits in verbal episodic memory (Rey Auditory Verbal Learning Test delayed recall 10.6 +/- 0.4 vs. 8.6 +/- 0.6, t = 4.97, df = 49, p < 0.01) and language (Weschler's vocabulary 51.4 +/- 1.3 vs. 44.3 +/- 1.5, t = 2.49, df = 49, p < 0.001) compared to CS, even though all participants had results within the clinically normal range. O-LOAD showed a phase-delayed rhythm of body temperature (2.56 +/- 0.47 h vs. 3.8 +/- 0.26 h, t = 2.48, df = 40, p = 0.031). Cognitive performance in O-LOAD was associated with a series of cardiac autonomic sleep-wake variables; specifically indicators of greater sympathetic activity at night were related to poorer cognition. The present results suggest sleep pattern deserves further study as a potential neurobiological signature in LOAD, even in middle-aged, at risk individuals.

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