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  • 1.
    Blom, Anna
    et al.
    University of Skövde, School of Health and Education.
    Söderqvist, Mercedes
    University of Skövde, School of Health and Education.
    VACCINATION IS MORE THAN JUST AN INJECTION – To vaccinate a student with fear of needles2018Independent thesis Advanced level (degree of Master (One Year)), 10 credits / 15 HE creditsStudent thesis
    Abstract [sv]

    Bakgrund: Vaccinationer är en del av skolsköterskors förebyggande arbete. Stickrädsla är en vanlig åkomma, upp till 10 % av befolkningen i världen uppskattas ha det. Skolsköterskor möter någon gång under sin tid, stickrädda elever. God information innan vaccinationen har visat att stickrädsla minskar. Syftet: Att belysa skolsköterskors upplevelse av att vaccinera stickrädda elever. Metod: Studien genomfördes med en kvalitativ metod. Semistrukturerade intervjuer genomfördes med åtta skolsköterskor i två mindre städer, i mellersta Sverige. Resultatet har analyserats med innebördsanalys. Resultat: Analysen resulterade i fyra rubriker till resultatet; Skolsköterskors förhållningssätt påverkar bemötandet av elever, En inbjudande miljö påverkar hur vaccinationen upplevs av skolsköterskor och elever, Föräldrars förhållningssätt kan hjälpa eller stjälpa skolsköterskor vid vaccination, Avledning vid vaccination underlättar arbetet för skolsköterskor. Konklusion: Skolsköterskor måsta ha en god kunskap om hur olika faktorer kan påverka den stickrädda elever. Skolsköterskor upplever ofta en tidspress vilket påverkar mötet med stickrädda elever som i sin tur påverkar skolsköterskors vaccinationer. Skolsköterskor upplever att belöning har en god effekt för att lugna elever och underlätta för skolsköterskor att utföra sitt arbete. Hur föräldern är delaktig är betydelsefullt för skolsköterskors upplevelse. Det finns tre olika förhållningssätt bland föräldrar, den tysta, den bestämda och den tveksamma som låter elever själv välja. Dessa påverkar vaccinationstillfället och upplevelsen av mötet för verksamma skolsköterskor.

  • 2.
    Borgström, Juliana
    University of Skövde, School of Bioscience.
    Cyclical Women: Menstrual Cycle Effects on Mood and Neuro-Cognitive Performance2019Independent thesis Basic level (degree of Bachelor), 15 credits / 22,5 HE creditsStudent thesis
    Abstract [en]

    During roughly forty years of a woman’s life-span, the fertile female human body prepares itself monthly for the possibility of pregnancy. Science has shown that the fluctuation of the sex steroids progesterone and estrogen have a crucial role in the female body's physiology, determining the menstrual cycle and its general phases. This biological dance of hormones governing the cycle influences a lot of physical, mental and cognitive aspects of life for a fertile ovulating woman. Although the question of whether these changes also affect women's cognitive performance is still unclear, some evidence has been gathered that could bring us closer to answers. Recent research findings show that this hormonal interplay might have a significant role in cognitive and psychological development - modulating brain activity, cognitive performance, higher cognition, emotional status, sensory processing, appetite and more. This thesis aims to uncover to what extent the menstrual cycle affects brain functions, neurobiology, mood, well-being and cognitive performance in menstruating cisgender women.

  • 3.
    Bäckström, Caroline
    et al.
    University of Skövde, School of Life Sciences.
    Hertfelt Wahn, Elisabeth
    University of Skövde, School of Life Sciences.
    Support during labour: first-time fathers' descriptions of requested and received support during the birth of their child2011In: Midwifery, ISSN 0266-6138, E-ISSN 1532-3099, Vol. 27, no 1, p. 67-73Article in journal (Refereed)
    Abstract [en]

    Objective:  to explore how first-time fathers describe requested and received support during a normal birth. Design:  qualitative research design. Ten first-time fathers were interviewed during the first postpartum week.  Individual  open-ended  interviews  were  used  to  explore  the  fathers’  descriptions,  and  the interviews were analysed using qualitative analysis. Setting:  a labour ward at one hospital in a south-western county of Sweden in November and December 2006. Participants:  first-time  fathers  who  had  experienced  a  normal  birth  at  the  hospital  during  the study period. Findings:  the support described is presented as one main theme, ‘being involved or being left out’, which included four underlying categories: ‘an allowing atmosphere’, ‘balancing involvement’, ‘being seen’ and ‘feeling left out’. Key conclusions:  fathers perceived that they were given good support when they were allowed to ask questions during labour, when they had the opportunity to interact with the midwife and their partner, and when they could choose when to be involved or to step back. Fathers want to be seen as individuals who are part of the labouring couple. If fathers are left out, they tend to feel helpless; this can result in a feeling of panic and can put their supportive role of their partner at risk. Implications  for practice:  the  results  of  this  study could  initiate  discussions  about  how  health-care professionals can develop support given to the labouring couple, with an interest in increasing paternal involvement.

  • 4.
    Bäckström, Caroline
    et al.
    University of Skövde, School of Health and Education. University of Skövde, Health and Education. Skaraborg Hospital Skövde, Woman, Child (K3), Skövde, Sweden / Jönköping University, School of Health and Welfare, CHILD-research group, Jönköping, Sweden.
    Thorstensson, Stina
    University of Skövde, School of Health and Education. University of Skövde, Health and Education.
    Mårtensson, Lena B.
    University of Skövde, School of Health and Education. University of Skövde, Health and Education.
    Grimming, Rebecca
    University of Skövde, School of Health and Education. Närhälsan Skaraborg, Young Persons Clinic, Skövde, Sweden.
    Nyblin, Yrsa
    University of Skövde, School of Health and Education. Danderyd Hospital AB, Women’s care, Gynecology ward, Stockholm, Sweden.
    Golsäter, Marie
    Jönköping University, School of Health and Welfare, CHILD-research group, Jönköping, Sweden.
    'To be able to support her, I must feel calm and safe': pregnant women's partners perceptions of professional support during pregnancy2017In: BMC Pregnancy and Childbirth, ISSN 1471-2393, E-ISSN 1471-2393, Vol. 17, p. 1-11, article id 234Article in journal (Refereed)
    Abstract [en]

    Background: Professional support does not always meet the needs of expectant fathers or co-mothers. The way in which professional support is offered during pregnancy varies internationally, depending on the country. In order to attain a greater understanding of partners' experiences of professional support, it is necessary to further illuminate their perceptions of it. The aim of this study was therefore to explore pregnant women's partners' perceptions of professional support during pregnancy. Methods: Qualitative research design. Partners of pregnant women were interviewed during gestational week 36-38. Individual semi-structured interviews were used to explore the partners' perceptions. The data was analysed using a phenomenographic approach. The study was performed in a county in south-western Sweden; the data collection was conducted from November 2014 to February 2015. Fourteen partners (expectant fathers and co-mothers) of women who were expectant first-time mothers with singleton pregnancies, were interviewed. Results: The findings of the study are presented through four descriptive categories: Ability to absorb adequate information; Possibility to meet and share with other expectant parents; Confirmation of the partner's importance; and Influence on the couple relationship. Using a theoretical assumption of the relationship between the categories showed that the fourth category was influenced by the other three categories. Conclusions: The partners perceived that professional support during pregnancy could influence the couple relationship. The partners' ability to communicate and to experience togetherness with the women increased when the expectant couple received professional support together. The support created also possibilities to meet and share experiences with other expectant parents. In contrast, a lack of support was found to contribute to partners' feelings of unimportance. It was essential that the midwives included the partners by confirming that they were individuals who had different needs for various types of professional support. The partners perceived it easier to absorb information when it was adequate and given with a pedagogic that made the partners become interested and emotionally engaged.

  • 5.
    Dalal, Koustuv
    et al.
    University of Skövde, School of Health and Education. University of Skövde, Health and Education. School of Health and Medical Sciences, Örebro University, Örebro, Sweden.
    Lee, Ming-Shinn
    National Dong Hwa University, Hualien, Taiwan.
    Ussatayeva, Gainel
    Kazakhstan School of Public Health, Almaty, Kazakhstan.
    Gifford, Mervyn
    School of Health and Medical Sciences, Örebro University, Örebro, Sweden.
    Female genital mutilation: a multi-country study2015In: HealthMed, ISSN 1840-2291, E-ISSN 1986-8103, Vol. 9, no 4, p. 161-167Article in journal (Refereed)
  • 6.
    Erichsen Andersson, Annette
    et al.
    The Sahlgrenska Academy, Institute of Health and Care Sciences, University of Gothenburg, Gothenburg, Sweden / Department of Anesthesia, Surgery, and Intensive Care, Sahlgrenska University Hospital/Östra, Gothenburg, Sweden.
    Petzold, Max
    Akademistatistik - Centre for Applied Biostatistics, The Sahlgrenska Academy, University of Gothenburg, Gothenburg, Sweden.
    Bergh, Ingrid
    University of Skövde, School of Health and Education. University of Skövde, Health and Education.
    Karlsson, Jón
    Department of Orthopedics, Sahlgrenska University Hospital, Gothenburg, Sweden / The Sahlgrenska Academy, Institute of Clinical Sciences, University of Gothenburg, Gothenburg, Sweden.
    Eriksson, Bengt I.
    Department of Orthopedics, Sahlgrenska University Hospital, Gothenburg, Sweden / The Sahlgrenska Academy, Institute of Clinical Sciences, University of Gothenburg, Gothenburg, Sweden.
    Nilsson, Kerstin
    The Sahlgrenska Academy, Institute of Health and Care Sciences, University of Gothenburg, Gothenburg, Sweden.
    Comparison between mixed and laminar airflow systems in operating rooms and the influence of human factors: Experiences from a Swedish orthopedic center2014In: American Journal of Infection Control, ISSN 0196-6553, E-ISSN 1527-3296, Vol. 42, no 6, p. 665-669Article in journal (Refereed)
  • 7.
    Geberemedhin, Mengistu Tadese
    University of Skövde, School of Life Sciences.
    The Filzig protein affects embryonic cuticle and taenidia organization in Drosophila2011Independent thesis Advanced level (degree of Master (One Year)), 20 credits / 30 HE creditsStudent thesis
    Abstract [en]

    Abstract

    The surface of multicellular organisms is covered with epithelial cells that provide a barrier to the external environment. As part of this barrier function, most epithelia produce apical extracellular matrices (aECMs). The generation of such chemical and physical barriers requires specialized deposition of macromolecules and is likely to involve a spatial and temporal coordination of biochemical activities at the apical surface. A challenging task is thus to characterize key proteins that underlie apical cell surface organization and correct aECM assembly. The Drosophila trachea provides an excellent system to study aECM formation, as they produce an ordered aECM, called the cuticle. The tracheal cuticle is unique by its presence of cuticular ridges, called taenidial folds, which prevent collapse of tracheal tubes while allowing them to expand and contract along their length. A gene called filzig encodes a transmembrane serine protease and is required for taenidial organization. The aim of this research was to further understand Filzig function through characterization of filzig mutants and Filzig protein expression. The results showed that Filzig is expressed in cuticle-producing epithelia as cuticle deposition begins. Moreover, Flz localized to the apical epithelial surface, as well as to the aECM. The apical Flz localization does not reflect the pattern of cuticle ridges, indicating that Flz-localization is not a determinant for taneidial patterning. Instead, Flz might act on extracellular targets that localize to the future taneidial folds. Alternatively, Filzig is involved in a cascade of self-organizing activity of cuticular components to form the regular taenidial folds.

     

  • 8. Hellberg, Ingela
    et al.
    Augustsson, Veronica
    Hellström Muhli, Ulla
    University of Skövde, School of Life Sciences.
    Elderly people’s experiences of living in special housing accommodation2011In: International Journal of Qualitative Studies on Health and Well-being, ISSN 1748-2623, E-ISSN 1748-2631, Vol. 6, no 1, p. 5894-Article in journal (Refereed)
  • 9.
    Hellqvist, Pernilla
    et al.
    University of Skövde, School of Health and Education.
    Jungner, Lina
    University of Skövde, School of Health and Education.
    Kärlek ska inte göra ont - kvinnors erfarenheter av att leva i en våldsutsatt relation: En självbiografistudie2018Independent thesis Basic level (degree of Bachelor), 10 credits / 15 HE creditsStudent thesis
    Abstract [en]

    Background: About 20% of Sweden's women say that they have ever been exposed toviolence in close relationships. Maltreatment and violence can be expressed bothphysically and mentally which creates suffering in their self-image whose can be distorted.Women´s experiences can be helpful and play an important role for healthcare professionalin order to support and help the women. Aim: The purpose was to describe women'sexperiences of living in a violent relationship. Method: An inductive approach was chosenwhere the data consisting of autobiographies were analyzed using qualitative contentanalysis.Findings: The analysis revealed three categories; begins to recognize partners´ violentqualities despite a loving relationship, emotional chaos and the way out of violence andsubsequent process. These three categories created nine subcategories. Conclusion:Through women´s experiences of living in violent relationships, the nurse can gain indepthknowledge of the subject that can help to build trust and faith in these women in thecare of the careers.

  • 10.
    Hellström Muhli, Ulla
    University of Skövde, School of Life Sciences.
    Accounts of Pain Experience in a Swedish Elderly Care Context2010In: Communication & Medicine: An Interdisciplinary Journal of Healthcare, Ethics and Society, ISSN 1612-1783, E-ISSN 1613-3625, Vol. 7, no 1, p. 56-64Article in journal (Refereed)
  • 11.
    Hellström Muhli, Ulla
    University of Skövde, School of Life Sciences.
    Delaktighet i äldreomsorgens språkliga möten2012In: Delaktighet i samtal, - Kommunikationens villkor och förutsättningar för delaktighet i vård, omsorg och socialt arbete / [ed] P. Bülow, I. Sandén & D. Thunqvist-Persson, Malmö: Gleerups Utbildning AB, 2012Chapter in book (Other academic)
  • 12.
    Hellström Muhli, Ulla
    et al.
    University of Skövde, School of Life Sciences.
    Delbene, Roxana
    The ethical dimension of presence in elderly care talk-encounter2012In: Discursive, ethical, and psychological dimensions of Presence in Health Care Communication – implications for professional education / [ed] J.C. Gonçalves, Niteroi: Editora da Universidade Federal Fluminense , 2012Chapter in book (Refereed)
  • 13.
    Hellström Muhli, Ulla
    et al.
    University of Skövde, School of Life Sciences.
    Karlsson, Christina
    University of Skövde, School of Life Sciences.
    Registered nurses' shared knowledge construction of dementia careManuscript (preprint) (Other academic)
  • 14.
    Huvila, Isto
    et al.
    Department of ALM, Uppsala University, Sweden / Information Studies, Åbo Akademi University, Turku, Finland.
    Hirvonen, Noora
    Information Studies, Åbo Akademi University, Turku, Finland / Information Studies, University of Oulu, Finland.
    Enwald, Heidi
    Information Studies, Åbo Akademi University, Turku, Finland / Information Studies, University of Oulu, Finland.
    Åhlfeldt, Rose-Mharie
    University of Skövde, School of Informatics. University of Skövde, The Informatics Research Centre.
    Differences in Health Information Literacy Competencies Among Older Adults, Elderly and Younger Citizens2019In: Information Literacy in Everyday Life: 6th European Conference, ECIL 2018, Oulu, Finland, September 24–27, 2018, Revised Selected Papers / [ed] Serap Kurbanoğlu, Sonja Špiranec, Yurdagül Ünal, Joumana Boustany, Maija Leena Huotari, Esther Grassian, Diane Mizrachi, Loriene Roy, Springer, 2019, Vol. 989, p. 136-143Chapter in book (Refereed)
    Abstract [en]

    To address the research gap on age-based differences in health information literacy (HIL), we investigated how younger (born 1960–) and older adults (1946–1960), and elderly citizens (–1945) differed from each other by their HIL competencies. Data were collected with an online survey of patients using the Swedish national electronic health record system. Altogether, 2,587 users responded. One-way ANOVA with post hoc tests revealed several differences between the groups: younger adults were less likely to value health information than older adults; older adults and elderly were least likely to compare information from multiple sources and had trouble in determining health information needs; older adults were most likely to have trouble understanding health terminology and the elderly to have difficulties in understanding medicinal package labels. The study shows that HIL is not necessarily improving or declining but adapting to challenges of advanced age. © 2019, Springer Nature Switzerland AG.

  • 15.
    Johansson, Elin
    et al.
    University of Skövde, School of Health and Education.
    Andersson, Åsa
    University of Skövde, School of Health and Education.
    NUTRITIONSPROBLEM HOS PATIENTER I LIVETS SLUTSKEDE: Ur ett sjuksköterskeperspektiv2015Independent thesis Basic level (degree of Bachelor), 10 credits / 15 HE creditsStudent thesis
    Abstract [en]

    Background: Every year nurses are faced different problems and questions regarding palliative care in end of life. Treatment of nutrition is one of the methods to relieve the situation for the patient and relatives. When there are number of individuals that are involved in the treatment, like doctors, nurses, it is important that everyone is informed and understand the situation, so that the patient get the best treatment. Aim: The aim of this study is to describe nurses experiences of nutrition problems when nursing patients at the end of life. Methods: A literature study was performed, 10 quantitative and qualitative articles were examined and analyzed according to Friberg (2012). Result: There were three different categories who are crucial for the outcome of nursing; Ethical considerations which focus on the patient and relatives. Communication; where the nurse plays a crucial role as a bond between patient/relatives and the doctor. Supervision and cooperation; where the individual nursing plan is an important success factor as a close cooperation between all involved. Conclusion: Crusial for a good palliative care where nutrition treatment are involved is the nurse role to communicate information from patient/relatives to the doctor in order to give the best conditions for correct nursing or no nursing at all. 

  • 16.
    Johansson, Karin
    et al.
    Department of Health and Care Sciences, Faculty of Health and Life Science, Linnaeus University, Växjö, Sweden / Department of Administration, Kronoberg County Council, Växjö, Sweden / Primary Care, Region Kronoberg County Council, Växjö, Sweden.
    Almerud Österberg, Sofia
    Department of Health and Care Sciences, Faculty of Health and Life Science, Linnaeus University, Växjö, Sweden.
    Leksell, Janeth
    School of Health and Social Sciences, University Dalarna, Falun, Sweden / Department of Medical Sciences, Uppsala University, Uppsala, Sweden.
    Berglund, Mia
    University of Skövde, Health and Education. University of Skövde, School of Health and Education.
    Patients' experiences of support for learning to live with diabetes to promote health and well-being: A lifeworld phenomenological study2016In: International Journal of Qualitative Studies on Health and Well-being, ISSN 1748-2623, E-ISSN 1748-2631, Vol. 11, article id 31330Article in journal (Refereed)
    Abstract [en]

    Learning to live with diabetes in such a way that the new conditions will be a normal and natural part of life imposes requirements on the person living with diabetes. Previous studies have shown that there is no clear picture of what and how the learning that would allow persons to incorporate the illness into their everyday life will be supported. The aim of this study is to describe the phenomenon of support for learning to live with diabetes to promote health and well-being, from the patient’s perspective. Data were collected by interviews with patients living with type 1 or type 2 diabetes. The interviews were analysed using a reflective lifeworld approach. The results show that reflection plays a central role for patients with diabetes in achieving a new understanding of the health process, and awareness of their own responsibility was found to be the key factor for such a reflection. The constituents are responsibility creating curiosity and willpower, openness enabling support, technology verifying bodily feelings, a permissive climate providing for participation and exchanging experiences with others. The study concludes that the challenge for caregivers is to create interactions in an open learning climate that initiates and supports reflection to promote health and well-being.

  • 17.
    Kader, Shoxan
    University of Skövde, School of Bioscience.
    Modulation of nlrp3 inflammasome by sp110: Regulation and inhibition of NLRP3 inflammasome in Sp110 deficient THP-1 cells2016Independent thesis Advanced level (degree of Master (One Year)), 20 credits / 30 HE creditsStudent thesis
  • 18.
    Karlsson, Suzana
    et al.
    University of Skövde, School of Health and Education.
    Cederqvist, Petra
    University of Skövde, School of Health and Education.
    Skolsköterskans upplevelse av att stödja och stärka elever med neuropsykiatriska funktionsnedsättningar - En intervjustudie2018Independent thesis Advanced level (degree of Master (One Year)), 40 credits / 60 HE creditsStudent thesis
    Abstract [en]

    Background: Children with neuropsychiatric disabilities (NPF) are in need of support and importance to be seen in the health care sector in school. The primary duty of the school nurse is to ensure that the students are in wellbeing. School nurses are supporting and strengthening the good of health by being present, listening and giving hope in the dialogue.

    Purpose: Describing school nurse's experience of supporting and strengthening students with neuropsychiatric disabilities

    Method: The study used a qualitative method with inductive approach where eight interviews were analyzed with qualitative content analysis. Result: Two major categories emerged from the analysis; Entering security and hope through accessibility and conversation and Strengthening cooperation with others, with five belonging subcategories.

    Conclusion: The school nurse's support in school leads the neuropsychiatric disabilities students feeling stronger in their situation, which gives greater hope and faith in the future. Helping students to promote their health and healthy behaviors helps to strengthen the students' protection factors. Through dialogue and responsiveness, students are strengthened to learn to make their own decisions and grow as individuals. Good teamwork contributes to greater opportunities for promoting health and preventing illness for students with neuropsychiatric disabilities.

  • 19.
    Kraft, Elin
    et al.
    University of Skövde, School of Health and Education.
    Härling, Maria
    University of Skövde, School of Health and Education.
    Kvinnors upplevelser av att leva med utmattningssyndrom och deras upplevda stöd från omgivningen2015Independent thesis Basic level (university diploma), 10 credits / 15 HE creditsStudent thesis
  • 20.
    Laaksonen, L.
    et al.
    University of Turku, Turku, Finland / Turku University Hospital, Turku, Finland.
    Kallioinen, M.
    Turku University Hospital, Turku, Finland.
    Långsjö, J.
    Tampere University Hospital, Tampere, Finland.
    Laitio, T.
    Turku University Hospital, Turku, Finland.
    Scheinin, A.
    University of Turku. Turku, Finland / Turku University Hospital, Turku, Finland.
    Scheinin, J.
    Kuopio University Hospital, Kuopio, Finland.
    Kaisti, K.
    Oulu University Hospital, Oulu, Finland.
    Maksimow, A.
    Turku University Hospital, Turku, Finland.
    Kallionpää, R. E.
    Turku University Hospital, Turku, Finland / University of Turku, Turku, Finland.
    Rajala, V.
    Turku University Hospital, Turku, Finland.
    Johansson, J.
    University of Turku, Turku, Finland / Turku University Hospital, Turku, Finland / Umeå University, Umeå, Sweden.
    Kantonen, O.
    University of Turku, Turku, Finland / Turku University Hospital, Turku, Finland / University of California, Irvine, CA, USA.
    Nyman, M.
    Turku University Hospital, Turku, Finland.
    Sirén, S.
    Turku University Hospital, Turku, Finland.
    Valli, Katja
    University of Skövde, School of Bioscience. University of Skövde, The Systems Biology Research Centre. Turku University Hospital, Turku, Finland / University of Turku, Turku, Finland.
    Revonsuo, Antti
    University of Skövde, School of Bioscience. University of Skövde, The Systems Biology Research Centre. University of Turku, Turku, Finland.
    Solin, O.
    University of Turku, Turku, Finland / Turku University Hospital, Turku, Finland.
    Vahlberg, T.
    University of Turku, Turku, Finland / Turku University Hospital, Turku, Finland.
    Alkire, M.
    University of California, Irvine, CA, USA.
    Scheinin, Harry
    University of Turku, Turku, Finland / Turku University Hospital, Turku, Finland.
    Comparative effects of dexmedetomidine, propofol, sevoflurane, and S-ketamine on regional cerebral glucose metabolism in humans: a positron emission tomography study2018In: British Journal of Anaesthesia, ISSN 0007-0912, E-ISSN 1471-6771, Vol. 121, no 1, p. 281-290Article in journal (Refereed)
    Abstract [en]

    IntroductionThe highly selective α2-agonist dexmedetomidine has become a popular sedative for neurointensive care patients. However, earlier studies have raised concern that dexmedetomidine might reduce cerebral blood flow without a concomitant decrease in metabolism. Here, we compared the effects of dexmedetomidine on the regional cerebral metabolic rate of glucose (CMRglu) with three commonly used anaesthetic drugs at equi-sedative doses.

    MethodsOne hundred and sixty healthy male subjects were randomised to EC50 for verbal command of dexmedetomidine (1.5 ng ml−1n=40), propofol (1.7 μg ml−1n=40), sevoflurane (0.9% end-tidal; n=40) or S-ketamine (0.75 μg ml−1n=20) or placebo (n=20). Anaesthetics were administered using target-controlled infusion or vapouriser with end-tidal monitoring. 18F-labelled fluorodeoxyglucose was administered 20 min after commencement of anaesthetic administration, and high-resolution positron emission tomography with arterial blood activity samples was used to quantify absolute CMRglu for whole brain and 15 brain regions.

    ResultsAt the time of [F18]fluorodeoxyglucose injection, 55% of dexmedetomidine, 45% of propofol, 85% of sevoflurane, 45% of S-ketamine, and 0% of placebo subjects were unresponsive. Whole brain CMRglu was 63%, 71%, 71%, and 96% of placebo in the dexmedetomidine, propofol, sevoflurane, and S-ketamine groups, respectively (P<0.001 between the groups). The lowest CMRglu was observed in nearly all brain regions with dexmedetomidine (P<0.05 compared with all other groups). With S-ketamine, CMRgludid not differ from placebo.

    ConclusionsAt equi-sedative doses in humans, potency in reducing CMRglu was dexmedetomidine>propofol>ketamine=placebo. These findings alleviate concerns for dexmedetomidine-induced vasoconstriction and cerebral ischaemia.

  • 21.
    Larsson, Emma
    et al.
    University of Skövde, School of Health and Education.
    Andreasson, Niclas
    University of Skövde, School of Health and Education.
    Återhämtning genom vistelse i naturen: En litteraturöversikt om naturens påverkan på stress2018Independent thesis Basic level (degree of Bachelor), 10 credits / 15 HE creditsStudent thesis
    Abstract [en]

    Background: Stress related ill health is today a common condition that causes personal suffering. Stress is about imbalance between load and recovery. Long-term stress can result in a life situation that gives both mental and physical ill health. For those who work in human-care professions, it is therefore important to be able to recognize stress and its symptoms Aim: To illustrate how people with stress experience visits in nature. Method: The chosen method is a literature review where qualitative and quantitative articles have been studied. Results: Visiting nature contributes to psychological recovery from stress. Stressed people find it easier to get their everyday life together thanks to the recovery they experience through visiting nature. The ability to reflect on ones lifesituation increases through visiting nature and also the power and ambition to take on the future. Also physical recovery is experienced through visiting nature. Experiencing nature through senses as sight, feeling, taste and smell is experienced to have a calming and relaxing impact. Generally, visiting nature contributes to feeling anchored in existence and experiencing feelings like joy and gratitude. Conclusion: The result shows that people suffering from stress experiences recovery through visits in the nature.

  • 22.
    Lind, Johanna
    University of Skövde, School of Health and Education.
    Mindfulness Based Stress Reduction - en potentiell hälsofrämjande intervention mot stressrelaterad ohälsa i svenska samhället?: En litteraturöversikt2018Independent thesis Basic level (professional degree), 5 credits / 7,5 HE creditsStudent thesis
    Abstract [en]

    Introduction: Stress-related illness is a growing public health concern which induces suffering for individuals and high costs for society. There is a need for health promotion and prevention methods to counteract this illness. MBSR is a method which demonstrates promising effects on stress reduction and different dimensions of stress-related illness.                                      

    Aim: The aim of this literature review was to describe the effects of Mindfulness Based Stress Reduction (MBSR) on stress in healthy populations.                                                                                                     

    Methods: A literature review of ten scientific articles were systematically analyzed to identify themes in effects of MBSR on stress-related ill health.                                      

    Results: All scientific studies show how MBSR has positive health effects such as increased mindfulness, reduced stress as well as better mental and emotional health.              

    Discussion: In previous studies MBSR has proven to be effective in enhancing quality of life as well as management of chronic pain conditions and various physical and mental disorders. Less attention has been paid to possible benefits in healthy population. The result of this literature review show how MBSR can be a promising method to promote health and prevent stress-related illness in healthy populations in the short perspective, as confirmed by previous studies.

  • 23.
    Lundin, Anette
    et al.
    University of Skövde, School of Health and Education. University of Skövde, Health and Education. School of Health Sciences at Jönköping University, Sweden.
    Berg, Lars-Erik
    University of Skövde, School of Health and Education.
    Hellström Muhli, Ulla
    Department of Sociology (Faculty of Social Sciences), Uppsala University, Uppsala, Sweden.
    Witnessing presence: Swedish care professionals' experiences of supporting resident's well-being processes within the frame of residential care homes (RCH)2016In: Journal of Aging Studies, ISSN 0890-4065, E-ISSN 1879-193X, Vol. 37, p. 1-9Article in journal (Refereed)
    Abstract [en]

    The purpose of this article is to analyse the phenomenon of supportive care for older persons' well-being. The phenomenon is seen from the eldercarers' meaning-making through their lifeworld perspective at a residential care home. Based on primary empirical interview material with twelve professionals in the context of Swedish eldercare, a phenomenological analysis was undertaken. The result shows that the phenomenon of supportive care for older persons' well-being creates certain ambiguities in the professionals' meaning-making. In practice, it balances between the older persons' (from hereon called residents) needs and the conditions of the eldercare organization. The ambiguities (the what) is made up by three constituents: (i) freedom of choice for the older persons vs. institutional constraints, (ii) the residents' need for activation vs. wanting not to be activated, and (iii) the residents' need for routine vs. the eldercarers' not being able to know what the residents need. The conclusions drawn are that this ambiguity has consequences for the eldercarers' choice of handling supportive care for older persons' well-being (the how). They have to navigate between the support for authenticity, dwelling and mobility, and their own presence and time. In performing supportive care for older persons' well-being, the eldercarers have to consider aspects concerning the resident's lifeworld, the social setting of the eldercare ward, and the institutional demands of the organization. The practical implications for supporting well-being in the care of older residents are manifested in the importance of 'the little things', and the eldercarer's ability to give receptive attention, which requires presence.

  • 24.
    Mattsson, Karin
    et al.
    Mälardalen University, Eskilstuna.
    Pietilä Rosendahl, Sirpa
    Mälardalen University, Eskilstuna.
    Teaching gerontology in globalized academics: a qualitative study of Thai nursing students' views on ageing when studying abroad.2017In: Contemporary Nurse: health care across the lifespan, ISSN 1037-6178, E-ISSN 1839-3535, Vol. 53, no 1, p. 36-47Article in journal (Refereed)
    Abstract [en]

    BACKGROUND: Negative views towards ageing and older adults may be a reason why nurses do not choose to work in gerontological nursing. Studying in another cultural context can challenge these views. The Objective was to explore nursing students' views on ageing and older adults before and after a gerontology course held abroad.

    DESIGN AND METHOD: A qualitative approach based on content analysis of responses to open-ended questions by 30 Thai nursing students studying a gerontology course in Sweden.

    RESULTS: Three main categories: positive imprints of ageing, ageing takes its toll, and knowledge leading to action, emerged through sub-categories carrying a view of older adults as not only in need of care, but also as resourceful and competent. Professional healthcare, besides family was seen as potential caregivers in old age.

    CONCLUSIONS: Studying gerontology abroad can widen views towards ageing and older adults, inspiring nurses to work in gerontological nursing.

  • 25.
    Ngabonziza, Inga
    University of Skövde, School of Health and Education.
    Främja fysisk aktivitet och förebygga övervikt och fetma bland barn oh ungdomar: En systematisk litteraturöversikt2016Independent thesis Basic level (degree of Bachelor), 10 credits / 15 HE creditsStudent thesis
    Abstract [en]

    Background: Overweight and obesity are among the most important contributing causes of death in the world, making up 2,6million deaths. In Sweden, 18-20% of 10 years old children are overweight and 3-4 % have obesity.

    Aim: The purpose of this study is to evaluate the effects of interventions that promote physical activity and prevent obesity among children and adolescents.

    Method: A literature review, based on article search in PubMed limited to publication from 2000-2019. The report was finally based on ten selected articles and the target group was children and adolescents 1-18 years.

    Results: The main results were presented in two thematic areas: 1. Factors that affect young people's physical activity. 2. Efforts to promote physical activity and prevent overweight and obesity among children. The studies showed that a combination of physical activities and other interventions such as healthy eating habits, as well as conveying knowledge about obesity to parents and teachers, give larger effects than other types of analyzed efforts that focus only on physical activities or just meal habits to prevent obesity among children and young people.

    Conclusion: Although obesity is a complex public health issue, it has been shown that physical activity combined with other initiatives that include meal habits and conveying knowledge about obesity to parents and teachers are efficient preventive measures against overweight among children. However, additional studies are needed to gain an understanding of how the physical activity should be undertaken to be optimally efficient in preventing obesity and factors that promote childhood physical activity.

  • 26.
    Nilsson, Håkan
    University of Skövde, School of Health and Education. University of Skövde, Health and Education. Högskolan i Jönköping, Hälsohögskolan.
    Conceptualizing and contextualizing mindfulness: New and critical perspectives2015Doctoral thesis, comprehensive summary (Other academic)
    Abstract [en]

    This dissertation aims at analyzing mindfulness as a concept and a multidimensional phenomenon in its historic and primordial but also contemporary contexts. In the course of examining this more general question, this dissertation targets four specific objectives: 1) classifying existing definitions of mindfulness, 2) critically analyzing and interpreting the Buddhist and Western interpretations and practices of mindfulness, 3) elaborating on the social and existential dimensions of mindfulness, and 4) applying these dimensions in advancing the notion of mindful sustainable aging in the context of successful aging. Paper I examines and assesses the numerous definitions of mindfulness that have been presented over the years by a wide range of scholars from a variety of disciplines. Paper II traces the roots of modern mindfulness in Buddhism. It continues by exploring the utility and practices of mindfulness in the context of social work. The definitions provided in Paper I and the Buddhist underpinnings discussed in Paper II call attention to the fact that in addition to the more commonly considered physical and mental dimensions, mindfulness contains a social and an existential dimension as well – dimensions that remain under-researched and not well understood. To redress this imbalance, Paper III elaborates on these two latter dimensions, emphasizing their potential to enhance health, wellbeing and meaning in life. Paper III further argues that a more nuanced understanding of physical, mental, social and existential mindfulness can be obtained by examining the interconnectedness of all four fields. Paper IV continues the discussion of the social and the existential dimensions of mindfulness with specific emphasis on their utility for successful aging, and advances the notion of mindful sustainable aging. Paper IV highlights the potential of mindfulness for living a meaningful life and boosting the elderly’s capacity to find deeper meaning in their final stage of life.

  • 27.
    Nilsson, Håkan
    et al.
    University of Skövde, School of Health and Education. University of Skövde, Health and Education. Jönköping University.
    Bülow, Pia H.
    Jönköping University / University of the Free State, Bloemfontein, South Africa.
    Kazemi, Ali
    University of Skövde, School of Health and Education. University of Skövde, Health and Education.
    Mindful sustainable aging: Advancing a comprehensive approach to the challenges and opportunities of old age2015In: Europe's Journal of Psychology, ISSN 1841-0413, E-ISSN 1841-0413, Vol. 11, no 3, p. 494-508Article in journal (Refereed)
    Abstract [en]

    The primary aim of this article is to present a new concept called mindful sustainable aging (MSA), which is informed by mindfulness practices that support the physical, the mental, and especially, the social and the existential dimensions of old life. The concept of MSA is discussed and compared with four influential psychosocial theories in the field of gerontology, i.e., activity theory, disengagement theory, successful aging theory and gerotranscendence theory. The article ends with reviewing research on how mindfulness practice can help to manage, diminish and/or improve a number of serious physical conditions that are common among older people. The potential of mindfulness when it comes to facilitating for older adults in their quest for spiritual and existential meaning is discussed extensively throughout the article.

  • 28.
    Olivari, Maria Giulia
    et al.
    Psychology Department, CRIdee, Università Cattolica del Sacro Cuore, Milano, Italy.
    Hertfelt Wahn, Elisabeth
    University of Skövde, School of Health and Education. University of Skövde, Health and Education.
    Maridaki-Kassotaki, Katerina
    Department of Home Economics and Ecology, Harokopio University of Athens, Athens, Greece.
    Antonopoulou, Katerina
    Department of Home Economics and Ecology, Harokopio University of Athens, Athens, Greece.
    Confalonieri, Emanuela
    Psychology Department, CRIdee, Università Cattolica del Sacro Cuore, Milano, Italy.
    Adolescent Perceptions of Parenting Styles in Sweden, Italy and Greece: An Exploratory Study2015In: Europe's Journal of Psychology, ISSN 1841-0413, E-ISSN 1841-0413, Vol. 11, no 2, p. 244-258Article in journal (Refereed)
  • 29.
    Olivari, Maria Giulia
    et al.
    Catholic University of Milan, Italy / CRIdee, Italy.
    Ionio, C.
    Catholic University of Milan, Italy / CRIdee, Italy.
    Traficante, D.
    Catholic University of Milan, Italy / CRIdee, Italy.
    Hertfelt Wahn, Elisabeth
    University of Skövde, School of Health and Education. University of Skövde, Health and Education.
    Confalonieri, Emanuela
    Catholic University of Milan, Italy / CRIdee, Italy.
    Contraceptive self efficacy among Italian adolescents2012Conference paper (Refereed)
  • 30.
    Olofsson, Emmie
    University of Skövde, School of Bioscience.
    Children of Divorce: Long-Term Psychological Effects and Neurological Consequences2019Independent thesis Basic level (degree of Bachelor), 15 credits / 22,5 HE creditsStudent thesis
    Abstract [en]

    This thesis has examined what long-term psychological and neurological effects that are apparent in children and adults who have experienced parental divorce. It was predicted that significantly more children and adult children from divorced families would have increased symptoms of mental disorders than children and adult children from married homes e.g., anxiety, depression, panic disorder, and generalized anxiety disorder. It was further predicted that parental divorce would negatively affect the neurological system in the offspring. The correlation between children of divorce and negative neurological effects was not found to be true. However, adult children of divorce have significantly lower baseline cortisol levels compared to adult children of marriage. Dysregulated cortisol levels are highly associated with the development of e.g., anxiety, depression, and brain damage. Parental divorce did not only influence how secretion of the hormone cortisol is regulated within adult children of divorce, but how both children and adult children of divorce psychologically adapt postdivorce. Children of divorce have for instance lower general well-being, more symptoms of anxiety and depression, lower self-esteem, and feel more stress than children of marriage. Adult children of divorce are more likely to experience marital discord, getting divorced themselves, anxiety and depression, lower academic performance, and substance abuse, etc. The result of the thesis suggests that children and adult children from divorced families are negatively affected, both psychologically and neurologically, regardless of age. Parental divorce and supplementary effects make it more likely for children and adult children to experience more symptoms of mental disorders.

  • 31.
    Pernestig, Anna-Karin
    Karolinska Institute, Stockholm.
    The study of the Escherichia coli BarA-UvrY two-component system and its ability to sense the environment.2003Doctoral thesis, comprehensive summary (Other academic)
  • 32.
    Pernestig, Anna-Karin
    et al.
    Microbiology and Tumorbiology Center, Karolinska Institutet, Stockholm.
    Georgellis, Dimitris
    Departamento de Genética Molecular, Instituto de Fisiología Celular, Universidad Nacional Autónoma de México.
    Romeo, Tony
    Department of Microbiology and Immunology, Emory University, Atlanta, Georgia.
    Suzuki, Kazushi
    Department of Microbiology and Immunology, Emory University, Atlanta, Georgia.
    Tomenius, Henrik
    Microbiology and Tumorbiology Center, Karolinska Institutet, Stockholm.
    Normark, Staffan
    Microbiology and Tumorbiology Center, Karolinska Institutet, Stockholm.
    Melefors, Öjar
    Microbiology and Tumorbiology Center, Karolinska Institutet, Stockholm / Swedish Institute for Infectious Disease Control, Solna, Sweden.
    The Escherichia coli BarA-UvrY two-component system is needed for efficient switching between glycolytic and gluconeogenic carbon sources2003In: Journal of Bacteriology, ISSN 0021-9193, E-ISSN 1098-5530, Vol. 185, no 3, p. 843-853Article in journal (Refereed)
    Abstract [en]

    The Escherichia coli BarA and UvrY proteins were recently demonstrated to constitute a novel two-component system, although its function has remained largely elusive. Here we show that mutations in the sensor kinase gene, barA, or the response regulator gene, uvrY, in uropathogenic E. coli drastically affect survival in long-term competition cultures. Using media with gluconeogenic carbon sources, the mutants have a clear growth advantage when competing with the wild type, but using media with carbon sources feeding into the glycolysis leads to a clear growth advantage for the wild type. Results from competitions with mutants in the carbon storage regulation system, CsrA/B, known to be a master switch between glycolysis and gluconeogenesis, led us to propose that the BarA-UvrY two-component system controls the Csr system. Taking these results together, we propose the BarA-UvrY two-component system is crucial for efficient adaptation between different metabolic pathways, an essential function for adaptation to a new environment.

  • 33.
    Pernestig, Anna-Karin
    et al.
    Microbiology and Tumorbiology Center, Karolinska Institutet, Stockholm, Sweden.
    Melefors, Öjar
    Microbiology and Tumorbiology Center, Karolinska Institutet, Stockholm, Sweden.
    Georgellis, Dimitris
    Department of Microbiology and Molecular Genetics, Harvard Medical School, Boston, Massachusetts.
    Identification of UvrY as the cognate response regulator for the BarA sensor kinase in Escherichia coli2001In: Journal of Biological Chemistry, ISSN 0021-9258, E-ISSN 1083-351X, Vol. 276, no 1, p. 225-231Article in journal (Refereed)
    Abstract [en]

    BarA is a membrane-associated protein that belongs to a subclass of tripartite sensors of the two-component signal transduction system family. In this study, we report that UvrY is the cognate response regulator for BarA of Escherichia coli. This conclusion is based upon homologies with analogous two-component systems and demonstrated by both biochemical and genetic means. We show that the purified BarA protein is able to autophosphorylate when incubated with [gamma-(32)P]ATP but not with [alpha-(32)P]ATP or [gamma-(32)P]GTP. Phosphorylated BarA, in turn, acts as an efficient phosphoryl group donor to UvrY but not to the non-cognate response regulators ArcA, PhoB, or CpxR. The specificity of the transphosphorylation reaction is further supported by the fact that UvrY can receive the phosphoryl group from BarA-P but not from the non-cognate tripartite sensor ArcB-P or ATP. In addition, genetic evidence that BarA and UvrY mediate the same signal transduction pathway is provided by the finding that both uvrY and barA mutant strains exhibit the same hydrogen peroxide hypersensitive phenotype. These results provide the first biochemical evidence as well as genetic support for a link between BarA and UvrY, suggesting that the two proteins constitute a new two-component system for gene regulation in Escherichia coli.

  • 34.
    Pernestig, Anna-Karin
    et al.
    Microbiology and Tumorbiology Center, Karolinska Institutet, Stockholm, Sweden.
    Normark, Staffan J.
    Microbiology and Tumorbiology Center, Karolinska Institutet, Stockholm, Sweden.
    Georgellis, Dimitris
    Department of Microbiology and Molecular Genetics, Harvard Medical School, Boston, MA, USA.
    Melefors, Öjar
    Microbiology and Tumorbiology Center, Karolinska Institutet, Stockholm, Sweden.
    The role of the AirS two-component system in uropathogenic Escherichia coli2000In: Genes and Proteins Underlying Microbial Urinary Tract Virulence: Basic Aspects and Applications: Session II / [ed] Levente Emoődy, Tibor Pál, Jörg Hacker, Gabriele Blum-Oehler, Springer, 2000, Vol. 485, p. 137-142Conference paper (Refereed)
  • 35.
    Pietilä Rosendahl, Sirpa
    et al.
    Institute of Gerontology, School of Health Sciences, Jönköping University, Sweden / School of Health, Care and Social Welfare, Mälardalen University, Eskilstuna, Sweden.
    Bülow, Pia
    Department of Behavioural Science and Social Work, Jönköping University, Sweden.
    Björklund, Anita
    Department of Rehabilitation, School of Health Sciences, Jönköping University, Sweden.
    Images of sorrow: Experiences of losing a co-twin in old age2013In: Health, ISSN 1949-4998, E-ISSN 1949-5005, Vol. 5, no 12A, p. 64-73Article in journal (Refereed)
    Abstract [en]

    What it is like when a lifelong twin relationship ends through death in later life is the focus of this study. It draws on interview data from seven twins who are part of a longitudinal Swedish twin study (SATSA) and who lost their co-twins in old age. Data were analyzed using qualitative latent content analysis. The results showed that the experience of loss of the co-twin was pro-found, including an emotional as well as a be-havioral dimension. Loss and loneliness were expressed as the dominant feelings related to the quality of the missing relationship as well as the loss of twin identity. However, the grief ex-periences in this study were primarily related to the closeness and quality of the twin relation-ship, rather than identity. Behavioral adjust-ments included the use of outside as well as internal cognitive resources to cope with life after the loss. Despite the devastating experi-ence of losing a co-twin after a lifelong rela-tionship, the participants engaged actively in their own grief processes. It was concluded that twin loss is unique, in the sense of losing the relational twin identity, as well as it is charac-terized by similar features as the loss of a close relationship among non-twins.

  • 36.
    Pietilä Rosendahl, Sirpa
    et al.
    Mälardalen University, School of Health, Care and Social Welfare, Division of Caring Sciences, Eskilstuna, Sweden.
    Söderman, Mirkka
    Mälardalen University, School of Health, Care and Social Welfare, Division of Caring Sciences, Eskilstuna, Sweden.
    Mazaheri, Monir
    Mälardalen University, School of Health, Care and Social Welfare, Division of Caring Sciences, Eskilstuna, Sweden / Faculty of Nursing and Midwifery, Tehran University of Medical Sciences, Iran.
    Immigrants with dementia in Swedish residential care: An exploratory study of the experiences of their family members and nursing staff2016In: BMC Geriatrics, ISSN 1471-2318, E-ISSN 1471-2318, Vol. 16, no 18, p. 1-12, article id 200Article in journal (Refereed)
    Abstract [en]

    Background

    Worldwide, there is a growing population of older people who develop dementia in a country other than that of their origin. When their dementia has reached an advanced stage, residential care is most often needed. People with dementia in Sweden are often cared for in group homes. For immigrants, this may mean a linguistically challenging care environment for both healthcare staff and the patients’ family members.

    The aim of this study was to explore and describe the experiences of family members and professional caregivers regarding the care provided to immigrants with dementia in group homes in Sweden.

    Methods

    An exploratory, descriptive study with a qualitative approach was chosen. In-depth semi-structured interviews were conducted with nine professional caregivers and five family members of people with dementia with Finnish, Estonian, Hungarian and Ingrian backgrounds; all were chosen purposefully. All people with dementia had lost their Swedish language skills as their second language. The data was analysed using qualitative content analysis.

    Results

    Three main categories and seven subcategories were identified. The first main category: A new living situation comprised the subcategories: adjusting to new living arrangements and expectations regarding activities and traditional food at the group home, the second main category: Challenges in communication with the subcategories: limited communication between the immigrant with dementia and the Swedish-speaking nursing staff and the consequences of linguistic misunderstandings and nuanced communication in a common language and the third main category: The role of the family member at the group home with the subcategories: a link to the healthy life story of the family member with dementia andan expert and interpreter for the nursing staff.

    Conclusions

    The family member played a crucial role in the lives of immigrants with dementia living in a group home by facilitating communication between the nursing staff and the PWD and also by making it possible for PWD to access the cultural activities they wanted and which professional caregivers were either not able to recognise as needed or could not deliver.

  • 37.
    Pietilä, Sirpa
    Högskolan i Jönköping, HHJ, Institutet för gerontologi.
    Tvillingskap genom livet: individualitet och relation i äldre tvillingars livsberättelser2012Doctoral thesis, comprehensive summary (Other academic)
    Abstract [en]

    The overall aim of this thesis was to explore, describe and understand experiences of twinship as told in the life stories of older twins. The 35 older twins who participated in this thesis were part of two longitudinal studies of older twins, SATSA (the Swedish Adoption Twin Study of Aging) and the Gender study. The study design is qualitative and the 35 interviews were collected using a narrative method. The life stories were analysed with narrative analysis (studies I and II) and qualitative, latent content analysis (studies III and IV).

    According to the twins in this thesis, twinship, was described from the relationship with the co-twin(I, III, IV) and from an identity perspective (II). Twin relationships are unique and different in their own way. Three relationship patterns were identified and labelled as: nurturing, draining or superficial based on qualitative aspects (I). The differences in the three relationship patterns became even more evident during critical stages in life, for example, when getting married (III) or losing the co-twin through death (IV). These events became turning points which meant that the twins needed to adjust to a more individualized life. Twins in nurturing or superficial relationship patterns did not experience these transitions as particularly dramatic, while for twins in draining relationships these life transitions were more dramatic. From an attachment theory point of view, the older twins remained attachment figures with an unaltered attachment pattern throughout life(I). Bound together with the close twin relationship is how twins define themselves, since the twinship means handling both your individual identity and the twin identity. The self-descriptions, with emphasis on differences, are viewed against the background of how the twins experienced the environment perceiving them as a social unity and were interpreted as a desire to emphasize ones individuality as related to the twin partner and as a message to the environment of desiring to be viewed as a unique individual (II).

    In summary twinship was described by most as a close, enriching relationship throughout life and for some, less enriching depending on what kind of relationship they had with their twin partner. An identity work was at the same time taking place, trying to establish a position as an individual in the twin relationship and to assert ones individuality to the rest of the environment in the message:“We are not as alike as you think!”

  • 38.
    Pietilä, Sirpa
    et al.
    Research School of Health and Welfare, School of Health Sciences, Jönköping University, Sweden / Institute of Gerontology, School of Health Sciences, Jönköping University, Sweden.
    Björklund, Anita
    Department of Rehabilitation, School of Health Sciences, Jönköping University, Sweden.
    Bülow, Pia
    Department of Behavioral Science and Social Work, Jönköping University, Sweden.
    Older twins' experiences of the relationship with their co-twin over the life course2012In: Journal of Aging Studies, ISSN 0890-4065, E-ISSN 1879-193X, Vol. 26, no 2, p. 119-128Article in journal (Refereed)
    Abstract [en]

    Based on 35 life stories of aging twins, this study focuses on personal experiences and recollections of their relationships with the co-twin over the life course. The participants are part of two longitudinal Swedish twin studies on aging, SATSA and Gender. In the narrative analysis, three relationship patterns, labeled ‘nurturing’, ‘draining’, and ‘superficial’, emerged, pointing to qualitative aspects in the co-twin relationship. The dominating aspect was emotional closeness, which differed in the three relationship patterns. In the nurturing twin relationship pattern, emotional closeness was experienced as intimacy and yet independence, while in the draining relationship pattern it was experienced as dependence. The superficial twin relationship was experienced as distant and lacking in emotional involvement. Most of the relationship patterns seemed to remain the same throughout life. However, seen from a life course perspective, this study pointed to complexity and diversity in lifelong twin relationships.

  • 39.
    Rai, Vijeta
    University of Skövde, School of Bioscience.
    Screening of large collection of compounds for anti-human parainfluenza virus type-2 activity and evaluation of hit compounds2017Independent thesis Advanced level (degree of Master (One Year)), 20 credits / 30 HE creditsStudent thesis
    Abstract [en]

    Human parainfluenza virus type-2 (HPIV-2) is a highly contagious respiratory pathogen that can cause severe respiratory disease known as laryngotracheobronchitis or croup-like disease in children. No specific vaccine or an antiviral drug is currently approved for treatment of HPIV-2 infections. In this project, a library of 14400 diverse compounds had been screened for anti-HPIV-2 activities in cultures of African green monkey kidney cells. All compounds that inhibited the virus induced syncytium-forming activity in these cells were considered as hit compounds. Three hit compounds showed moderate anti-HPIV-2 activity characterized by the IC50 values of 20 µM and selectivity indices of approximately 5. This suggests that the antiviral activity of these compounds was due to targeting activities of cellular rather than viral components. Another hit compound, referred to as compound 5, showed anti-HPIV-2 activity that was manifested as a reduction of area of the virus-induced plaques in cells at not cytotoxic concentrations. Interestingly, this compound did not inhibit initial infection nor the virus production in infected cells as revealed by the time-of-addition assay. Moreover, it showed no direct the virus-inactivating (virucidal activity) against HPIV-2 particles. However, relatively short pre-treatment (4 hours) of the cells with compound 5 prior to the virus infection was sufficient for its plaque size-reducing activity suggesting that anti-HPIV-2 activity of compound 5 was due to targeting activities of cellular rather than viral components. Further studies are needed to elucidate the anti-HPIV-2 mechanism of activity of hit compounds identified in the present study.

  • 40.
    Rendon, Patricia
    University of Skövde, School of Health and Education.
    Att arbeta förebyggande, ett viktigt men tidskrävande arbete: Vårdpersonalens erfarenheter av munvård hos personer med demenssjukdom2018Independent thesis Basic level (university diploma), 10 credits / 15 HE creditsStudent thesis
    Abstract [sv]

    Bakgrund: Personer med demens har kognitiva nedsättningar. De får svårt att sköta sin egen munhygien, detta leder till en förvärring av den kroniska sjukdomen. Bemötandet är avgörande då de behöver känna tillit personen som hjälper till med munvården. Hinder uppstår vid kunskapsbrist och motstånd. Senior alert är hjälpmedel där dålig munhälsa kan identifieras. Syfte: Att beskriva vårdpersonalens erfarenheter av att främja munhälsan hos personer med demens. Metod: Litteraturöversikt med kvantitativ och kvalitativ ansats. Resultat: Två teman uppkom: Kunskap ger kompetens som innebär att kunskap om demens symtom, munhygien samt munvård är viktiga delar till en god munvård. En god kommunikation med gott samarbete personal emellan samt gentemot patienter är även detta viktiga delar. Hinder ger känsla av obehag innefattar när munvården blir svår att utföra då personal upplever organisatoriska hinder som tidsbrist och otillräcklig personal tillsättning samt hinder från patienter som verbalt och fysiskt motstånd. Konklusion: Kunskap om demens och munvård är viktigt för att kunna bibehålla en bra munhälsa där utbildning är nyckeln till kunskapen. Denna bör ges under utbildningen men även under arbetstiden. Även ges kontinuerligt då det sker personalomväxlingar och forskning går framåt.

  • 41.
    Retz, Carolina
    et al.
    University of Skövde, The Systems Biology Research Centre.
    Andersson, Sofie
    Department of Clinical Microbiology, Unilabs AB, Skövde, Sweden.
    Enroth, Helena
    Department of Clinical Microbiology, Unilabs AB, Skövde, Sweden.
    Ljungström, Lars
    Department of Infectious Diseases, Skaraborg Hospital.
    Karlsson, Diana
    University of Skövde, The Systems Biology Research Centre. University of Skövde, School of Bioscience.
    Pernestig, Anna-Karin
    University of Skövde, The Systems Biology Research Centre. University of Skövde, School of Bioscience.
    Quicker identification of Gram-positive cocci in clusters in patients with suspected sepsis2014Conference paper (Refereed)
    Abstract [en]

    Sepsis is the primary cause of death from infection. Globally, an estimated 18 million people die from sepsis annually, exceeding deaths caused by HIV/AIDS, breast cancer, and prostate cancer combined1. Early sepsis diagnosis and targeted antimicrobial (AM) therapy reduce the length of intensive care for patients and cost by 30%2. The current gold standard, using blood cultures (BC), takes 12-72 h to detect pathogens in the blood and even longer to identify the exact pathogen and its AM susceptibility for optimal therapy. The aim of this study was to determine whether the QuickFISHTMBC test (AdvanDx, Woburn, MA) could be robust, timesaving and specific in the clinical microbiology laboratory setting, for identification of the pathogens causing life-threatening bloodstream infections.

  • 42.
    Rosendahl, Sirpa
    University of Skövde, School of Health and Education. University of Skövde, Health and Education.
    Traditional Meals and Sense of At-Homeness -: Finnish Immigrants with Dementia in Bilingual Residential Care in Sweden2019In: ICSS XIX, 12-13 July 2019: 19th International Conference on Social Sciences / [ed] Ahmet Ecirli, European Center for Science, Education and Research , 2019, p. 33-Conference paper (Refereed)
  • 43.
    Rosendahl, Sirpa
    et al.
    Institute of Gerontology, School of Health Sciences, Jönköping University, Sweden.
    Björklund, Anita
    Department of Rehabilitation, School of Health sciences, Jönköping University, Sweden.
    Bülow, Pia
    Department of Behavioral Science and Social work, Jönköping University, Sweden.
    'We are not as alike, as you think' sense of individuality within the co-twin relationship along the life course2013In: Journal of Aging Studies, ISSN 0890-4065, E-ISSN 1879-193X, Vol. 27, no 4, p. 339-346Article in journal (Refereed)
    Abstract [en]

    We have explored how older twins experience and describe themselves in relation to their co-twin. The life stories of 20 older twins were analyzed with narrative analysis.

    Results showed that the twins described themselves from the point of differences in relation to the co-twin. This was based on experiences of how other people viewed them as alike, as well as on life events along the life course, which contributed to the perception of oneself as an individual in relation to the co-twin. The emphasis on unlikeness was therefore interpreted as a way of trying to establish a position as an individual within the co-twin relationship and to assert ones individuality to the rest of the social environment. To claim oneself as an individual was an ongoing identity work along the life course.

  • 44.
    Rosendahl, Sirpa
    et al.
    University of Skövde, School of Health and Education. University of Skövde, Health and Education.
    Mattsson, Karin
    Department of Health Care Sciences, Ersta Sköndal Community College, Stockholm, Sweden / Department of Neurobiology, Care Sciences and Society (NVS) H1, Karolinska Institutet, Huddinge, Sweden.
    Yuwanich, Nuttapol
    School of Nursing Science, Rangsit University, Ptumthani, Thailand.
    Cross-cultural perspectives on gerontology in nursing education: a qualitative study of nurse educators’ experiences2019In: Gerontology & Geriatrics Education, ISSN 0270-1960, E-ISSN 1545-3847Article in journal (Refereed)
  • 45.
    Svensson, Ann-Marie
    et al.
    School of Health Sciences, Jönköping University, Jönköping, Sweden.
    Mårtensson, Lena
    University of Skövde, School of Life Sciences. College of Nursing, University of Rhode Island, USA.
    Hellström Muhli, Ulla
    Department of Sociology, Uppsala University, Sweden.
    Well-being dialogue: Elderly women’s subjective sense of well-being from their course of life perspective2012In: International Journal of Qualitative Studies on Health and Well-being, ISSN 1748-2623, E-ISSN 1748-2631, Vol. 7, p. Article Number: 19207-Article in journal (Refereed)
    Abstract [en]

    In this article, we are concerned with narratives of elderly women’s well-being from their perspectives of the latter parts of their life, living at special housing accommodation (SHA) in the context of Swedish elderly care. In focusing on narratives about well-being, we have a two-fold focus: (1) how the elderly women create their own identity and meaning-making based on lifetime experience; and (2) how narratives of well-being are reflected through the filter of life in situ at the SHA. Based on empirical data consisting of well-being narratives, a dialogical performance analysis was undertaken. The results show how relationships with important persons during various stages of life, and being together and enjoying fellowship with other people as well as enjoying freedom and self-determination, are central aspects of well-being. The conclusions drawn are that the characteristic phenomena of well-being (the what) in the narratives are continuity, identity, and sociality for the elderly person, and this is manifested (the how) as a question of contrasting the state of self-management and self-decline.

  • 46.
    Söderman, Mirkka
    et al.
    School of Health, Care and Social Welfare, Division of Caring Sciences and Health Care Education, Mälardalen University, Eskilstuna-Västerås, Sweden.
    Pietilä Rosendahl, Sirpa
    School of Health, Care and Social Welfare, Division of Caring Sciences and Health Care Education, Mälardalen University, Eskilstuna-Västerås, Sweden.
    Caring for Ethnic Older People Living with Dementia – Experiences of Nursing Staff2016In: Journal of Cross-Cultural Gerontology, ISSN 0169-3816, E-ISSN 1573-0719, Vol. 31, no 3, p. 311-326Article in journal (Refereed)
    Abstract [en]

    The total number of persons living with dementia is estimated to double every 20 years and ageing migrant populations are growing in several countries. There are gaps in the health and social care of people from other countries, regardless of the efforts made when someone has a dementia diagnosis; similarly, receiving care in sheltered accommodation is less common. The aim of this study was to explore and describe the nursing staff's experiences of caring for non-Swedish speaking persons living with dementia in a Finnish speaking group home in relation to a Swedish speaking group home in Sweden. 27 qualitative semi-structured interviews were analysed using qualitative content analyses. The first main category, "communication", concentrated on language abilities and deficiencies, non-verbal language, highlighting the consequences of not understanding and the benefits of a common language. The second main category, "culturally oriented activities", focused on being served traditional food, celebrating holidays at the group home, the importance of traditions and the importance of familiar music as cultural elements. The Swedish speaking nursing staff could provide qualitative and equitable care, but the challenge was greater for them than for the bilingual nursing staff who spoke the same language as the residents.

  • 47.
    Tagliabue, Semira
    et al.
    Department of Psychology, Università Cattolica del Sacro Cuore, Brescia, Italy.
    Olivari, Maria Giulia
    CRIdee, Department of Psychology, Università Cattolica del Sacro Cuore, Milano, Italy.
    Hertfelt Wahn, Elisabeth
    University of Skövde, School of Health and Education. University of Skövde, Health and Education.
    Maridaki-Kassotaki, Katerina
    Department of Home Economics and Ecology, Harokopio University, Athens, Greece.
    Antonopoulou, Katerina
    Department of Home Economics and Ecology, Harokopio University, Athens, Greece.
    Confalonieri, Emanuela
    CRIdee, Department of Psychology, Università Cattolica del Sacro Cuore, Milano, Italy.
    Retrospective Paternal and Maternal Parenting Styles in Greece, Italy, and Sweden2018In: European Journal of Psychological Assessment, ISSN 1015-5759, E-ISSN 2151-2426, Vol. 34, no 6, p. 399-408Article in journal (Refereed)
    Abstract [en]

    Abstract. Discrepancies in perceived parenting and parental roles across European countries could be due to the use of different assessment techniques or due to mean level differences in the authoritative, authoritarian, or permissive parenting styles. The present study aimed to examine the psychometric characteristics of the Parenting Styles and Dimensions Questionnaire (PSDQ; Robinson, Mandleco, Olsen, & Hart, 1995, 2001) in a sample of 225 Greek, 301 Italian, and 279 Swedish adolescents aged 16?19 years, who evaluated their father?s and mother?s parenting styles during their childhood. A confirmatory factor analysis (CFA), multigroup CFA, and modified version of the correlated uniqueness model were used to evaluate the structure and invariance of the scale across countries. Measurement and structural invariance was found in the 8-item authoritative scale and 6-item authoritarian scale. A mixed ANOVA (Country ? Style ? Role) showed that Swedish mothers scored lower than Italian or Greek mothers, and that, in the three countries, mothers were perceived as more authoritative than were fathers.

  • 48.
    Uvnäs-Moberg, Kerstin
    et al.
    University of Skövde, School of Health and Education. University of Skövde, Health and Education. Department of Animal Environment and Health, Swedish University of Agricultural Sciences, Skara, Sweden.
    Handlin, Linda
    University of Skövde, School of Health and Education. University of Skövde, Health and Education.
    Petersson, Maria
    Department of Molecular Medicine and Surgery, Endocrine and Diabetes Unit, Karolinska Institutet, Stockholm, Sweden.
    Self-soothing behaviors with particular reference to oxytocin release induced by non-noxious sensory stimulation2015In: Frontiers in Psychology, ISSN 1664-1078, E-ISSN 1664-1078, Vol. 5, article id 1529Article, review/survey (Refereed)
  • 49.
    Visuttijai, Kittichate
    University of Skövde, School of Bioscience. University of Skövde, The Systems Biology Research Centre. Department of Medical and Clinical Genetics, Sahlgrenska Academy, University of Gothenburg, Gothenburg.
    Cellular, Molecular and Functional Characterization of the Tumor Suppressor Candidate MYO1C2016Doctoral thesis, comprehensive summary (Other academic)
    Abstract [en]

    Tumor suppressor genes play a role as a growth regulator and a gatekeeper of a cell. Their inactivation is often detected in malignant tumors. Identification of novel tumor suppressor gene candidates may help to further understand tumorigenesis and aid in the discovery of a new treatment leading toward cure of cancer.

    This PhD research project aimed to understand functional significance of a novel tumor suppressor gene candidate, myosin IC (MYO1C) and to identify potential interaction(s) of the MYO1C protein with key components of the signaling pathways involving in cancer development.

    In an experimental rat model for endometrial carcinoma (EC), detailed molecular genetic analysis of a candidate tumor suppressor region located distal to the tumor protein 53 (Tp53) suggested the myosin IC gene (Myo1c) as the best potential target for deletion of the genetic material. The question arising was whether and how MYO1C could function as a tumor suppressor gene. By using qPCR, Western blot or immunohistochemistry analyses, we examined MYO1C protein level in panels of well-stratified human colorectal cancer (CRC) and EC respectively. We found that MYO1C was significantly down-regulated in these cancer materials and that for the EC panel, the observed down-regulation of MYO1C correlated with tumor stage, where tumors at more advanced stages had less expression of MYO1C. In cell transfection experiments, we found that over-expression of MYO1C significantly decreased cell proliferation, and silencing MYO1C with siRNA increased cell viability. Additionally, knockdown of MYO1C impaired the ability of cells to migrate, spread and adhere to the surface. Recent published studies suggested a potential interplay between MYO1C and the phosphoinositide 3-kinase (PI3K)/AKT pathway. To examine this hypothesis, we analyzed the expression and/or activation of components of the PI3K/AKT and RAS/ERK signaling pathways in vivo in CRC samples, and in vitro in cells transfected with the MYO1C gene expression construct or MYO1C-targeted siRNA. To identify other potential pathways/ mechanisms through which MYO1C may exert its tumor suppressor activity, we additionally performed new sets of MYO1C-siRNA knockdown experiments. At different time points post transfection, we performed microarray global gene expression experiments followed by bioinformatics analysis of the data. Altogether, the results suggested an early PI3K/AKT response to altered MYO1C expression. We additionally identified several cancer-related genes/pathways with late response to MYO1C knockdown. All things considered, the identification of MYO1C-expression impact on cell proliferation, migration, and adhesion in combination with its interplay between several cancer-related genes and signaling pathways provide further evidence for the initial hypothesis of a tumor suppressor activity of MYO1C. 

  • 50.
    Visuttijai, Kittichate
    et al.
    University of Skövde, School of Bioscience. University of Skövde, The Systems Biology Research Centre. Department of Medical and Clinical Genetics, Sahlgrenska Academy, University of Gothenburg.
    Pettersson, Jennifer
    Department of Medical and Clinical Genetics, Sahlgrenska Academy, University of Gothenburg, Gothenburg.
    Mehrbani Azar, Yashar
    University of Skövde, School of Bioscience.
    van den Bout, Iman
    Department of physiology, Faculty of Health Sciences, University of Pretoria, South Africa.
    Örndal, Charlotte
    Department of Pathology, Sahlgrenska University Hospital, Gothenburg.
    Marcickiewicz, Janusz
    Department of Obstetrics and Gynecology, Halland Hospital Varberg, Varberg.
    Nilsson, Staffan
    Institute of Mathematical Statistics, Chalmers University of Technology, Gothenburg.
    Hörnquist, Michael
    Department of Science and Technology, University of Linköping, Norrköping.
    Olsson, Björn
    University of Skövde, School of Bioscience. University of Skövde, The Systems Biology Research Centre.
    Ejeskär, Katarina
    University of Skövde, School of Bioscience. University of Skövde, The Systems Biology Research Centre.
    Behboudi, Afrouz
    University of Skövde, School of Bioscience. University of Skövde, The Systems Biology Research Centre.
    Lowered Expression of Tumor Suppressor Candidate MYO1CStimulates Cell Proliferation, Suppresses Cell Adhesion and Activates AKT2016In: PLoS ONE, ISSN 1932-6203, E-ISSN 1932-6203, Vol. 11, no 10, article id e0164063Article in journal (Refereed)
    Abstract [en]

    Myosin-1C (MYO1C) is a tumor suppressor candidate located in a region of recurrent losses distal to TP53. Myo1c can tightly and specifically bind to PIP2, the substrate of Phosphoinositide 3-kinase (PI3K), and to Rictor, suggesting a role for MYO1C in the PI3K pathway. This study was designed to examine MYO1C expression status in a panel of well-stratified endometrial carcinomas as well as to assess the biological significance of MYO1C as a tumor suppressor in vitro. We found a significant correlation between the tumor stage and lowered expression of MYO1C in endometrial carcinoma samples. In cell transfection experiments, we found a negative correlation between MYO1C expression and cell proliferation, and MYO1C silencing resulted in diminished cell migration and adhesion. Cells expressing excess of MYO1C had low basal level of phosphorylated protein kinase B (PKB, a.k.a. AKT) and cells with knocked down MYO1C expression showed a quicker phosphorylated AKT (pAKT) response in reaction to serum stimulation. Taken together the present study gives further evidence for tumor suppressor activity of MYO1C and suggests MYO1C mediates its tumor suppressor function through inhibition of PI3K pathway and its involvement in loss of contact inhibition.

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