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  • 1.
    Potter, Ryan
    et al.
    University of Skövde, School of Bioscience. University of Skövde, Systems Biology Research Environment. Sahlgrenska Academy, Gothenburg University, Sweden.
    Ayala, Marcelo
    Skaraborgs Sjukhus, Skövde, Sweden ; Karolinska Institutet: Stockholm, Sweden ; Sahlgrenska Academy, Gothenburg University, Sweden.
    Tilevik, Andreas
    University of Skövde, School of Bioscience. University of Skövde, Systems Biology Research Environment.
    Identification of biomarker candidates for exfoliative glaucoma from autoimmunity profiling2024In: BMC Ophthalmology, E-ISSN 1471-2415, Vol. 24, no 1, article id 44Article in journal (Refereed)
    Abstract [en]

    Background: Exfoliative glaucoma (XFG) is a subtype of open-angle glaucoma characterized by distinctive extracellular fibrils and a yet unknown pathogenesis potentially involving immune-related factors. The aim of this exploratory study was to identify biomarkers for XFG using data from autoimmunity profiling performed on blood samples from a Scandinavian cohort of patients. Methods: Autoantibody screening was analyzed against 258 different protein fragments in blood samples taken from 30 patients diagnosed with XFG and 30 healthy donors. The 258 protein fragments were selected based on a preliminary study performed on 3072 randomly selected antigens and antigens associated with the eye. The “limma” package was used to perform moderated t-tests on the proteomic data to identify differentially expressed reactivity between the groups. Results: Multiple associated genes were highlighted as possible biomarker candidates including FUT2, CDH5, and the LOX family genes. Using seven variables, our binary logistic regression model was able to classify the cases from the controls with an AUC of 0.85, and our reduced model using only one variable corresponding to the FUT2 gene provided an AUC of 0.75, based on LOOCV. Furthermore, over-representation gene analysis was performed to identify pathways that were associated with antigens differentially bound to self-antibodies. This highlighted the enrichment of pathways related to collagen fibril formation and the regulatory molecules mir-3176 and mir-876-5p. Conclusions: This study suggests several potential biomarkers that may be useful in developing further models of the pathology of XFG. In particular, CDH5, FUT2, and the LOX family seem to have a relationship which merits additional exploration. 

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  • 2.
    Sterner, Bertil
    et al.
    Department of Ophthalmology, Institute of Clinical Neuroscience, SU/Mölndal, Mölndal, Sweden.
    Gellerstedt, Martin
    Medical Informatics, The Sahlgrenska Academy at Göteborg University, Göteborg, Sweden.
    Sjöström, Anders
    Department of Ophthalmology, Institute of Clinical Neuroscience, SU/Mölndal, Mölndal, Sweden.
    Accommodation and the relationship to subjective symptoms with near work for young school children2006In: Ophthalmic & physiological optics, ISSN 0275-5408, E-ISSN 1475-1313, Vol. 26, no 2, p. 148-155Article in journal (Refereed)
    Abstract [en]

    The aim of this work was to study the relation between subjective symptoms at near and ocular accommodation in terms of the amplitude of accommodation and the relative accommodation. A secondary aim was to discuss the diagnosis of accommodative insufficiency. The chosen cohort was examined on two occasions with 1.8 years in between. The first examination included 72 children, 43 boys (mean age 8.1 years, ranging from 5.8 to 9.8) and 29 girls (mean age 8.3 years, ranging from 6.2 to 10.0). The second examination included 59 of these children, 34 boys (mean age 9.9 years, ranging from 7.8 to 11.7) and 25 girls (mean age 10.1 ranging from 8.0 to 11.8). Subjective symptoms at near work (headache, asthenopia, floating text, facility problems) were recorded and the amplitude and the relative accommodation, both positive and negative, were measured. The result from the questionnaire showed that at the first examination more than one-third of the children (34.7%) reported at least one subjective symptom when doing near work and 42.4% at the second examination. No symptoms were found among children younger than 7.5 years, but for children between 7.5 and 10 years old at the first examination, the prevalence of at least one symptom was 47.2%. At the second examination, symptoms were reported also for the youngest children, i.e. from the age of 8 years. The discrimination ability for the amplitude of accommodation, both monocular and binocular, was significant. In the first examination the difference between the mean for the two groups (i.e. with and without at least one symptom) was around 2.00 D monocular and 3.00 D binocular. Corresponding figures from the second examination was a difference between the mean for the two groups of around 3.50 D monocular and nearly 4.00 D binocular. We suggest that accommodation measurements should be performed more routinely and regularly, maybe as screening, especially in children over 8 years of age.

  • 3.
    Sterner, Bertil
    et al.
    Institute of Clinical Neuroscience, Department of Ophthalmology, The Sahlgrenska Academy at Göteborg University, Göteborg, Sweden.
    Gellerstedt, Martin
    Medical Informatics, The Sahlgrenska Academy at Göteborg University, Göteborg, Sweden.
    Sjöström, Anders
    Institute of Clinical Neuroscience, Department of Ophthalmology, The Sahlgrenska Academy at Göteborg University, Göteborg, Sweden.
    The amplitude of accommodation in 6-10-year-old children: not as good as expected!2004In: Ophthalmic & physiological optics, ISSN 0275-5408, E-ISSN 1475-1313, Vol. 24, no 3, p. 246-251Article in journal (Refereed)
    Abstract [en]

    The aim of this study was to measure the amplitude of accommodation for junior level school children and to compare it with age-expected values. A junior level school in Göteborg, Sweden, was randomly chosen and the amplitude of accommodation among 76 children aged 6-10 years was examined using Donders' push-up method. The results showed lower amplitude than expected in a large group of children. Results also showed lower amplitude than previously reported for this age group, especially under monocular conditions, which revealed an average dioptric difference from the expected value of -3.60 dioptres (D) right eye (mean 12.40 D, median 12.00 D, S.D. 3.7 D) and -3.50 D left eye (mean 12.50 D, median 12.70 D, S.D. 3.8 D) (p < 0.001 for both eyes). Consequently, we conclude that it cannot be assumed that the amplitude of accommodation is in the expected amplitude range for all children of these ages.

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