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Redox-based therapeutics in neurodegenerative disease
School of Biomolecular and Biomedical Science, Conway Institute, University College Dublin, Dublin, Ireland.
Instituto Teófilo Hernando for Drug Discovery, Department of Pharmacology, School of Medicine, Universidad Autónoma de Madrid, Madrid, Spain.
University of Skövde, School of Bioscience. University of Skövde, The Systems Biology Research Centre. Redoxis AB. (Infektionsbiologi, Infection Biology)ORCID iD: 0000-0002-2812-8255
2016 (English)In: British Journal of Pharmacology, ISSN 0007-1188, E-ISSN 1476-5381Article in journal (Refereed) Epub ahead of print
Abstract [en]

This review describes recent developments in the search for effective therapeutic agents that target redox homeostasis in neurodegenerative disease. The disruption to thiol redox homeostasis in Alzheimer's disease, Parkinson's disease, amyotrophic lateral sclerosis and multiple sclerosis is discussed, together with the experimental strategies that are aimed at preventing, or at least minimizing, oxidative damage in these diseases. Particular attention is given to the potential of increasing antioxidant capacity by targeting the Nrf2 pathway, the development of inhibitors of NADPH oxidases that are likely candidates for clinical use, together with strategies to reduce nitrosative stress and mitochondrial dysfunction. We describe the shortcomings of compounds that hinder their progression to the clinic and evaluate likely avenues for future research.

Place, publisher, year, edition, pages
John Wiley & Sons, 2016.
National Category
Pharmaceutical Sciences
Identifiers
URN: urn:nbn:se:his:diva-12916DOI: 10.1111/bph.13551PubMedID: 27477685OAI: oai:DiVA.org:his-12916DiVA: diva2:968157
Available from: 2016-09-12 Created: 2016-09-12 Last updated: 2017-03-06Bibliographically approved

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