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Clinical characteristics of asymptomatic left ventricular diastolic dysfunction and its association with self-rated health and N-terminal B-type natriuretic peptide: a cross-sectional study
Department of Public Health and Community Medicine/Primary Health Care, The Sahlgrenska Academy at the University of Gothenburg, Göteborg, Sweden.
Department of Clinical Sciences in Malmö, Family Medicine, Lund University, Malmö, Sweden.
Department of Public Health and Community Medicine/Primary Health Care, The Sahlgrenska Academy at the University of Gothenburg, Göteborg, Sweden / Department of Clinical Sciences in Malmö, Social Medicine and Global Health, Lund University, Malmö, Sweden.
University of Skövde, School of Health and Education. University of Skövde, Health and Education. (Äldre och långvariga hälsoproblem, Health and Ageing)ORCID iD: 0000-0002-2188-4306
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2016 (English)In: ESC Heart Failure, E-ISSN 2055-5822, Vol. 3, no 3, 205-211 p.Article in journal (Refereed) Published
Abstract [en]

AimsLeft ventricular hypertrophy, obesity, hypertension, and N-terminal B-type natriuretic peptide (Nt-proBNP) predict left ventricular diastolic dysfunction with preserved systolic function (DD-PSF). Self-rated health (SRH) is shown to be associated with chronic diseases, but the association of SRH with DD-PSF is unclear. In light of the clinical implications of DD-PSF, the following goals are of considerable importance: (1) to determine the role of SRH in patients with DD-PSF in the general population and (2) to study the association between Nt-proBNP and DD-PSF.

Methods and resultsThe current study is a cross-sectional study conducted on a random sampling of a rural population. Individuals 30–75 years of age were consecutively subjected to conventional echocardiography and tissue velocity imaging. Data were collected on 500 (48%) men and 538 (52%) women (n = 1038). DD-PSF was the main outcome, and SRH and Nt-proBNP were the primary indicators. Diabetes mellitus, hypertension, and obesity were accounted for as major confounders of the association with SRH. DD-PSF was identified in 137 individuals, namely, 79 men (15.8%) and 58 women (10.8%). In a multivariate regression model, SRH (OR 2.95; 95% CI 1.02–8.57) and Nt-proBNP (quartile 4 vs. quartile 1 OR 4.23; 95% CI 1.74–10.26) were both independently associated with DD-PSF.

ConclusionsSRH, evaluated based on a descriptive question on general health, should be included in the diagnostic process of DD-PSF. In agreement with previous studies, our study confirms that Nt-proBNP is a major indicator of DD-PSF.

Place, publisher, year, edition, pages
John Wiley & Sons, 2016. Vol. 3, no 3, 205-211 p.
Keyword [en]
DD-PSF, Nt-proBNP, SRH, Cross-sectional, Diabetes mellitus, Population-based
National Category
Family Medicine
Research subject
Medical sciences
URN: urn:nbn:se:his:diva-12913DOI: 10.1002/ehf2.12090ISI: 000381755300008OAI: oai:DiVA.org:his-12913DiVA: diva2:968098
Available from: 2016-09-12 Created: 2016-09-12 Last updated: 2016-10-28Bibliographically approved

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