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MicroRNAs as potential biomarkers for doxorubicin-induced cardiotoxicity
University of Skövde, School of Bioscience. University of Skövde, The Systems Biology Research Centre. Department of Clinical Chemistry and Transfusion Medicine, Institute of Biomedicine, University of Gothenburg, Sahlgrenska University Hospital, Gothenburg, Sweden. (Bioinformatik, Bioinformatics)ORCID iD: 0000-0002-0402-1437
University of Skövde, School of Bioscience. University of Skövde, The Systems Biology Research Centre. (Bioinformatik, Bioinformatics)ORCID iD: 0000-0003-4697-0590
Takara Bio Europe AB, Gothenburg, Sweden.
Department of Clinical Chemistry and Transfusion Medicine, Institute of Biomedicine, University of Gothenburg, Sahlgrenska University Hospital, Gothenburg, Sweden.
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2016 (English)In: Toxicology in Vitro, ISSN 0887-2333, E-ISSN 1879-3177, Vol. 34, p. 26-34Article in journal (Refereed) Published
Abstract [en]

Anthracyclines, such as doxorubicin, are well-established, highly efficient anti-neoplastic drugs used for treatment of a variety of cancers, including solid tumors, leukemia, lymphomas, and breast cancer. The successful use of doxorubicin has, however, been hampered by severe cardiotoxic side-effects. In order to prevent or reverse negative side-effects of doxorubicin, it is important to find early biomarkers of heart injury and drug-induced cardiotoxicity. The high stability under extreme conditions, presence in various body fluids, and tissue-specificity, makes microRNAs very suitable as clinical biomarkers. The present study aimed towards evaluating the early and late effects of doxorubicin on the microRNA expression in cardiomyocytes derived from human pluripotent stem cells. We report on several microRNAs, including miR-34a, miR-34b, miR-187, miR-199a, miR-199b, miR-146a, miR-15b, miR-130a, miR-214, and miR-424, that are differentially expressed upon, and after, treatment with doxorubicin. Investigation of the biological relevance of the identified microRNAs revealed connections to cardiomyocyte function and cardiotoxicity, thus supporting the findings of these microRNAs as potential biomarkers for drug-induced cardiotoxicity.

Place, publisher, year, edition, pages
Elsevier, 2016. Vol. 34, p. 26-34
National Category
Medical Biotechnology (with a focus on Cell Biology (including Stem Cell Biology), Molecular Biology, Microbiology, Biochemistry or Biopharmacy)
Research subject
Bioinformatics
Identifiers
URN: urn:nbn:se:his:diva-12339DOI: 10.1016/j.tiv.2016.03.009ISI: 000379273800004PubMedID: 27033315Scopus ID: 2-s2.0-84962362050OAI: oai:DiVA.org:his-12339DiVA, id: diva2:934169
Available from: 2016-06-08 Created: 2016-06-08 Last updated: 2018-07-31Bibliographically approved
In thesis
1. In vitro toxicity testing using human pluripotent stem cell derivatives
Open this publication in new window or tab >>In vitro toxicity testing using human pluripotent stem cell derivatives
2016 (English)Doctoral thesis, comprehensive summary (Other academic)
Place, publisher, year, edition, pages
University of Gothenburg, 2016. p. 82
Keywords
toxicity testing, human pluripotent stem cells, cardiomyocytes, hepatocytes, microarray, quantitative proteomics, bioinformatics, transcriptomics, microRNA
National Category
Bioinformatics and Systems Biology Cell Biology Medical Biotechnology (with a focus on Cell Biology (including Stem Cell Biology), Molecular Biology, Microbiology, Biochemistry or Biopharmacy)
Research subject
Medical sciences
Identifiers
urn:nbn:se:his:diva-13340 (URN)978-91-629-0001-4 (ISBN)978-91-629-0002-1 (ISBN)
Public defence
2016-12-15, 09:00 (English)
Opponent
Supervisors
Note

I avhandlingen ingår även:

Holmgren, G., Sartipy, P., Andersson, C.X., Lindahl, A., and Synnergren, J. Expression profiling of human pluripotent stem cell-derived cardiomyocytes exposed to doxorubicin – integration and visualization of multi omics data Manuscript

Available from: 2017-11-27 Created: 2017-01-26 Last updated: 2018-07-31Bibliographically approved

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Holmgren, GustavSynnergren, JaneSartipy, Peter

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