Mental ill-health is an increasing problem in Swedish society. If a parent is suffering from mental illness, it can have negative consequences for the child’s wellbeing, health and developmental process. The challenge for school nurses is to identify and support these students. The aim of this study is to describe school nurses’ experiences from meeting and supporting students who have parents with mental ill-health. Interviews with six school nurses were performed after snowball recruitment with purposive sampling and analysed using qualitative content analysis. School nurses’ experience of meeting and supporting students who have parents with mental ill-health shows that this is complex and demands competence and collaboration. Their competences in collaboration with others as well as their ability to show an open and tolerant attitude were important in order to build trustful relations with students, their parents and other professionals.