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Implication of high risk Human papillomavirus HR-HPV infection in prostate cancer in Indian population- A pioneering case-control analysis
University of Skövde, School of Bioscience. University of Skövde, The Systems Biology Research Centre. Department of Biotechnology, Panjab University, Chandigarh, India. (Tumörbiologi, Tumor Biology)ORCID iD: 0000-0003-2885-5708
Division of Molecular Oncology, Institute of Cytology and Preventive Oncology (ICMR), NOIDA, India.
Department of Histopathology, Post Graduate Institute of Medical Education and Research, Chandigarh, India.
Department of Urology, Post Graduate Institute of Medical Education and Research, Chandigarh, India.
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2015 (English)In: Scientific Reports, ISSN 2045-2322, E-ISSN 2045-2322, Vol. 5, 7822Article in journal (Refereed) Published
Abstract [en]

Prostate cancer is the second most common cancer with sexual history as a consistent risk factor. This is the pioneering study that evaluates the frequency of HPV infection in prostate cancer in India. Ninety five (95) histopathologically confirmed cancer and fifty five (55) BPH from Indian population were analyzed for HPV infection using a pair of consensus sequence primer followed by type specific PCRs for both high-risk and low-risk HPV types. The data demonstrate HPV infection in 41% of prostate tumor biopsies and 20% in BPH. Subsequent PCR- based HPV typing using type - specific primers revealed 32% were infected with HPV type 16 whereas 6% were found to be positive for HPV type 18, while in BPH controls only 5% of the BPH controls were infected with HPV 16 and this difference was highly significant (p = 0.0004). Significant proportion of HPV infected (74%) cases belonged to stage III and IV (p < 0.001) with a high Gleason score ≥8 (p = 0.003). The study represents for the first time the incidence of HPV infection in prostate cancer in Indian population and strengthens the hypothesis that HPV infection could be one of the co factor associated with progression of prostate cancer.

Place, publisher, year, edition, pages
Nature Publishing Group, 2015. Vol. 5, 7822
Keyword [en]
HPV infection, Prostate cancer, Viral oncology
National Category
Cancer and Oncology
Research subject
Medical sciences
Identifiers
URN: urn:nbn:se:his:diva-10607DOI: 10.1038/srep07822ISI: 000347903800003PubMedID: 25592643ScopusID: 2-s2.0-84929694497OAI: oai:DiVA.org:his-10607DiVA: diva2:782145
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Available from: 2015-01-20 Created: 2015-01-20 Last updated: 2016-10-27Bibliographically approved

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CiteExportLink to record
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