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MicroRNA expression in human endometrial adenocarcinoma
University of Skövde, School of Bioscience. University of Skövde, The Systems Biology Research Centre. (Tumörbiologi)
University of Skövde, The Systems Biology Research Centre. University of Skövde, School of Bioscience. (Bioinformatik)ORCID iD: 0000-0001-6254-4335
University of Skövde, The Systems Biology Research Centre. University of Skövde, School of Bioscience. (Tumörbiologi)
2014 (English)In: Cancer Cell International, ISSN 1475-2867, E-ISSN 1475-2867, Vol. 14, no 1, 88Article in journal (Refereed) Published
Abstract [en]

BACKGROUND: MicroRNAs are small non-coding RNAs that play crucial roles in the pathogenesis of different cancer types. The aim of this study was to identify miRNAs that are differentially expressed in endometrial adenocarcinoma compared to healthy endometrium. These miRNAs can potentially be used to develop a panel for classification and prognosis in order to better predict the progression of the disease and facilitate the choice of treatment strategy.

METHODS: Formalin fixed paraffin embedded endometrial tissue samples were collected from the Örebro university hospital. QPCR was used to quantify the expression levels of 742 miRNAs in 30 malignant and 20 normal endometrium samples. After normalization of the qPCR data, miRNAs differing significantly in expression between normal and cancer samples were identified, and hierarchical clustering analysis was used to identify groups of miRNAs with coordinated expression profiles.

RESULTS: In comparisons between endometrial adenocarcinoma and normal endometrium samples 138 miRNAs were found to be significantly differentially expressed (p < 0.001) among which 112 miRNAs have not been previous reported for endometrial adenocarcinoma.

CONCLUSION: Our study shows that several miRNAs are differentially expressed in endometrial adenocarcinoma. These identified miRNA hold great potential as target for classification and prognosis of this disease. Further analysis of the differentially expressed miRNA and their target genes will help to derive new biomarkers that can be used for classification and prognosis of endometrial adenocarcinoma.

Place, publisher, year, edition, pages
London: BioMed Central, 2014. Vol. 14, no 1, 88
Keyword [en]
Endometrial adenocarcinoma, MicroRNA, Quantitative polymerase chain reaction
National Category
Cancer and Oncology
Research subject
Medical sciences
Identifiers
URN: urn:nbn:se:his:diva-10451DOI: 10.1186/s12935-014-0088-6ISI: 000346199300001PubMedID: 25419182OAI: oai:DiVA.org:his-10451DiVA: diva2:773347
Funder
Knowledge Foundation, 2009/091
Available from: 2014-12-18 Created: 2014-12-18 Last updated: 2016-01-12Bibliographically approved
In thesis
1. MicroRNA expression profiling in endometrial adenocarcinoma
Open this publication in new window or tab >>MicroRNA expression profiling in endometrial adenocarcinoma
2015 (English)Doctoral thesis, comprehensive summary (Other academic)
Place, publisher, year, edition, pages
Örebro: Örebro university, 2015. 53 p.
Series
Örebro Studies in Medicine, ISSN 1652-4063 ; 118
Keyword
Endometrial cancer, microRNA, BDII rat model, normalization, endogenous controls
National Category
Cancer and Oncology
Research subject
Medicine
Identifiers
urn:nbn:se:his:diva-10886 (URN)9789175290638 (ISBN)
Public defence
2015-03-27, Portalen, Högskolan i Skövde, Högskolevägen, 09:00 (English)
Opponent
Supervisors
Available from: 2015-05-04 Created: 2015-05-04 Last updated: 2015-05-08Bibliographically approved

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Jurcevic, SanjaOlsson, BjörnKlinga-Levan, Karin
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CiteExportLink to record
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