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Explore transcription factor profiles in human pluripotent stem cells
University of Skövde, School of Bioscience. University of Skövde, The Systems Biology Research Centre. (Bioinformatics)ORCID iD: 0000-0003-4697-0590
2014 (English)In: 6th International Conference on Bioinformatics and Computational Biology (BICoB 2014): Las Vegas, Nevada, USA, 24 – 26 March 2014 / [ed] F. Saeed, B. DasGupta, International Society for Computers and Their Applications , 2014, 197-202 p.Conference paper, (Refereed)
Abstract [en]

Human pluripotent stem cells (hPSCs) have unique properties of proliferation and self-renewal, and can be differentiated into various functional cell types. The differentiation processes are to a large extent controlled by transcription factors, which are key cellular components that control gene expression and determine how cells respond to the environment on various stimuli. Surprisingly little is known about the transcription factor activity in hPSCs, and more knowledge is needed about the transcriptional regulation during the differentiation processes. This information will be instrumental for development of efficient differentiation protocols to produce fully functional specialized cell types, for use in drug discovery and toxicity testing studies. This paper explores the expression of transcription factors in hPSCs, and gives an overview of the genomic organization of transcription factors, which likely are involved in the fate decision processes of hPSCs. In total 1,323 human transcription factors were selected from literature and further investigated for their genomic organization and their expression in hPSCs. Moreover, transcription factors that are highly expressed in undifferentiated hPSCs, compared to their differentiated progenies are identified and further investigated for protein-protein interaction activity using computational tools. The protein-protein interaction networks presented here will provide valuable information about the regulatory mechanisms, and reveal important proteins involved in the maintenance of the pluripotent state of stem cells.

Place, publisher, year, edition, pages
International Society for Computers and Their Applications , 2014. 197-202 p.
National Category
Medical Biotechnology (with a focus on Cell Biology (including Stem Cell Biology), Molecular Biology, Microbiology, Biochemistry or Biopharmacy)
Identifiers
URN: urn:nbn:se:his:diva-10231Scopus ID: 2-s2.0-84905863089ISBN: 978-1-63266-514-0 OAI: oai:DiVA.org:his-10231DiVA: diva2:766654
Conference
6th international conference on Bioinformatics and Computational Biology (BICoB) Las Vegas, 24-26 March 2014
Funder
Knowledge Foundation, 2012/0310
Available from: 2014-11-27 Created: 2014-11-27 Last updated: 2014-11-28Bibliographically approved

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CiteExportLink to record
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Citation style
  • apa
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