The capability to predict high cycle fatigue properties of adhesive joints is important for cost-efficient and rapid product development in the modern automotive industry. Here, the adaptability of adhesives facilitates green technology through the widening of options of choosing and joining optimal materials. In the present paper a continuum damage mechanics model is developed based on the adhesive layer theory. In this theory, through-thickness averaged variables for the adhesive layer are used to characterise the deformation, damage and local loading on the adhesive layer. In FE-simulations, cohesive elements can thereby be used to model the adhesive layer. This simplifies simulations of large scale complex built-up structures. The model is adapted to experimental results for two very different adhesive systems; one relatively stiff rubber based adhesive and one soft polyurethane based adhesive. The model is able to reproduce the experimental results with good accuracy except for the early stage of crack propagation when the loads are relatively large. The model also predicts a threshold value for fatigue crack growth below which no crack growth occurs. The properties of the model are also compared with the properties of Paris’ law. The relations between the parameters of the continuum damage mechanics law and the parameters of Paris’ law are used to adapt the new law. It also shows that the properties of a joined structure influence the Paris’ law properties of the adhesive layer. Thus, the Paris’ law properties of an adhesive layer are not expected to be transferable to joints with adherends having different mechanical properties.