Physical activity can be beneficial to both physical and mental health, but can also lead to injuries. While injury rehabilitation through physical therapy is mostly focused on physical exercise, there are also other factors, which may influence rehabilitation outcome. The factorsreviewed are: rehabilitation adherence, mindfulness meditation, mental imagery, action observation, self-talk, goal-setting and social support. This essay investigates the neural correlates of these factors, as well as how they can affect rehabilitation outcome and wellbeing, to a lesser degree, during rehabilitation. Among the effects found are performance enhancement, increased self-efficacy, increased pain tolerance, increased motivation and reduced strength loss. Suggestions for future research is also provided.