This paper describes an application of simulation-based optimization within the aircraft engine manufacturing domain. The study is performed at the company GKN Aerospace and considers the optimization of priorities of components in x-ray stations. More specifically, the optimization aims to reduce delays by finding an efficient prioritization of components waiting to be x-rayed. An evolutionary optimization algorithm is being implemented and connected to a discrete-event simulation model for evaluating solutions. For deploying the simulation-based optimization, a web-based system is developed that adopts distributed simulation agents for increased efficiency. © 2014 EUROSIS-ETI.