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Impact of XPD gene polymorphism on risk of prostate cancer on north Indian population
Department of Biotechnology, Panjab University, 160014 Chandigarh, India.
Department of Biotechnology, University of Gondar, Gondar, Ethiopia.
Department of Mathematics, University of Gondar, Gondar, Ethiopia.
Department of Biotechnology, Panjab University, 160014 Chandigarh, India.
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2012 (English)In: Molecular and Cellular Biochemistry, ISSN 0300-8177, E-ISSN 1573-4919, Vol. 362, no 1-2, 263-8 p.Article in journal (Refereed) Published
Abstract [en]

Prostate cancer is the second most diagnosed cancer in men next to skin cancer in the developed world. Risk of disease varies most prominently with age, ethnicity, family history, and diet. Genetic polymorphism of some genes has been implicated in increasing the risk. The XPD (Xeroderma pigmentosum group D) gene codes for a DNA helicase involved in transcription and nucleotide excision repair. The aim of this study is to evaluate the effect of XPD 751 Lys/Gln polymorphism on risk of prostate cancer on north Indian patients. Blood sample from 150 prostate cancer patients, 150 from Prostate Hyper Plasia and equal number of samples from healthy control groups was collected from North India. The polymerase chain reaction and restrictive fragment length polymorphism techniques were implemented. Statistically non-significant increase risk of prostate cancer was observed with patients having Gln/Gln genotype (OR 1.62, 95% CI).

Place, publisher, year, edition, pages
Springer Science+Business Media B.V., 2012. Vol. 362, no 1-2, 263-8 p.
Keyword [en]
BPH, Prostate cancer, RFL, P XPD gene polymorphism
National Category
Cancer and Oncology
Research subject
Natural sciences
Identifiers
URN: urn:nbn:se:his:diva-9002DOI: 10.1007/s11010-011-1152-3ISI: 000299770600030PubMedID: 22116596Scopus ID: 2-s2.0-84857049121OAI: oai:DiVA.org:his-9002DiVA: diva2:712822
Available from: 2014-04-16 Created: 2014-04-16 Last updated: 2016-10-27Bibliographically approved

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CiteExportLink to record
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