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Association of cyclin D1 gene polymorphisms with risk of esophageal squamous cell carcinoma in Kashmir Valley: a high risk area
Institute of Cytology & Preventive Oncology (ICMR), Noida, Uttar Pradesh, India.
Institute of Cytology & Preventive Oncology (ICMR), Noida, Uttar Pradesh, India.
Institute of Cytology & Preventive Oncology (ICMR), Noida, Uttar Pradesh, India.
Sher-I-Kashmir Institute of Medical Sciences, Soura, Srinagar, Jammu and Kashmir, India.
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2011 (English)In: Molecular Carcinogenesis, ISSN 0899-1987, E-ISSN 1098-2744, Vol. 50, no 7, 487-98 p.Article in journal (Refereed) Published
Abstract [en]

Investigation of potential association of SNPs (G870A, rs9344; G1722C, rs678653) of cyclin D1 gene (CCND1) with susceptibility to esophageal squamous cell carcinoma (ESCC) in Kashmir valley (India). The study included 302 subjects comprising 151 ESCC cases and 151 controls. PCR-RFLP and direct sequencing were employed for genotyping. The G870A polymorphism, the individuals carrying GA + AA genotype was having 2.80-fold increased risk for development of ESCC (OR 2.8, 95% CI = 1.77-4.4; P = 0.0001) compared to GG genotype. Further a significantly higher risk was observed in individuals who consume >3 cups per day of salted tea (OR = 5.1; 95% CI = 1.6-16.7; P = 0.0016) and had smoking habits (OR = 6.3; 95% CI = 2.9-13.9; P = 0.0005). We also demonstrate for the first time in CCND1 1722 locus, the CC genotype was strongly associated with increased risk of developing ESCC (OR = 2.58; 95% CI = 1.61-4.15; P = 0.0001). In addition, the frequency of polymorphic C allele was also found to be higher in cases (OR = 1.92; 95% CI = 1.37-2.69; P = 0.0002). There appears to be an influence of CCND1 G870A/G1772C genotypes on genetic susceptibility to ESCC.

Place, publisher, year, edition, pages
Wiley-Blackwell, 2011. Vol. 50, no 7, 487-98 p.
Keyword [en]
CCND1, esophageal cancer, Kashmir; gene polymorphism
National Category
Cancer and Oncology
Research subject
Natural sciences
Identifiers
URN: urn:nbn:se:his:diva-9001DOI: 10.1002/mc.20732ISI: 000291606900001PubMedID: 21268129ScopusID: 2-s2.0-79958208160OAI: oai:DiVA.org:his-9001DiVA: diva2:712819
Available from: 2014-04-16 Created: 2014-04-16 Last updated: 2016-10-27Bibliographically approved

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