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Three-Dimensional Telomeric Analysis of Isolated Circulating Tumor Cells (CTCs) Defines CTC Subpopulations
University of Skövde, School of Life Sciences. University of Skövde, The Systems Biology Research Centre. University of Manitoba, CancerCare Manitoba, Canada / Sahlgrenska Academy, University of Gothenburg, Sweden .ORCID iD: 0000-0002-4524-0783
University of Manitoba, CancerCare Manitoba, Canada .
ScreenCell, Paris, France / Hôpital Henri Mondor, Créteil, France .
ScreenCell, Paris, France.
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2013 (English)In: Translational Oncology, ISSN 1944-7124, E-ISSN 1936-5233, Vol. 6, no 1, 51-65 p.Article in journal (Refereed) Published
Abstract [en]

Circulating tumor cells (CTCs) have been identified with the potential to serve as suitable biomarkers for tumor stage and progression, but the availability of effective isolation technique(s) coupled with detailed molecular characterization have been the challenges encountered in making CTCs clinically relevant. For the first time, we combined isolation of CTCs using the ScreenCell filtration technique with quantitative analysis of CTC telomeres by TeloView. This resulted in the identification and molecular characterization of different subpopulations of CTCs in the same patient. Three-dimensional (3D) telomeric analysis was carried out on isolated CTCs of 19 patients that consisted of four different tumor types, namely, prostate, colon, breast, melanoma, and one lung cancer cell line. With telomeric analysis of the filter-isolated CTCs, the level of chromosomal instability (CIN) of the CTCs can be determined. Our study shows that subpopulations of CTCs can be identified on the basis of their 3D telomeric properties.

Place, publisher, year, edition, pages
Neoplasia Press , 2013. Vol. 6, no 1, 51-65 p.
National Category
Natural Sciences
Research subject
Natural sciences
Identifiers
URN: urn:nbn:se:his:diva-8851DOI: 10.1593/tlo.12361ISI: 000318620200008PubMedID: 23418617Scopus ID: 2-s2.0-84874727652OAI: oai:DiVA.org:his-8851DiVA: diva2:696685
Available from: 2014-02-14 Created: 2014-02-14 Last updated: 2017-06-02Bibliographically approved

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Adebayo Awe, Julius
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CiteExportLink to record
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