his.sePublications
Change search
CiteExportLink to record
Permanent link

Direct link
Cite
Citation style
  • apa
  • ieee
  • modern-language-association-8th-edition
  • vancouver
  • Other style
More styles
Language
  • de-DE
  • en-GB
  • en-US
  • fi-FI
  • nn-NO
  • nn-NB
  • sv-SE
  • Other locale
More languages
Output format
  • html
  • text
  • asciidoc
  • rtf
Increases in Oxidized Low-Density Lipoprotein and Other Inflammatory and Adhesion Molecules With a Concomitant Decrease in High-Density Lipoprotein in the Individuals Exposed to Arsenic in Bangladesh
Rajshahi University, Bangladesh / Islamic University, Bangladesh.
Rajshahi University, Bangladesh.
Rajshahi University, Bangladesh.
Rajshahi University, Bangladesh.
Show others and affiliations
2013 (English)In: Toxicological Sciences, ISSN 1096-6080, E-ISSN 1096-0929, Vol. 135, no 1, 17-25 p.Article in journal (Refereed) Published
Abstract [en]

Elevated exposure to arsenic has been suggested to be associated with atherosclerosis leading to cardiovascular disease (CVD). However, biochemical events underlying the arsenic-induced atherosclerosis have not yet been fully documented. The aim of this study was to investigate the associations of circulating molecules involved in atherosclerosis with arsenic exposure in the individuals exposed to arsenic in Bangladesh. A total of 324 study subjects, 218 from arsenic-endemic areas and 106 from nonendemic areas in Bangladesh, were recruited. Drinking water, hair, nail, and blood samples were collected from the study subjects for analysis. Total cholesterol (TC), low-density lipoprotein (LDL), and high-density lipoprotein (HDL) levels were lower in arsenic-endemic subjects than those of nonendemic subjects. Oxidized LDL (Ox-LDL), C-reactive protein (CRP), intercellular adhesion molecule-1 (ICAM-1), and vascular cell adhesion molecule-1 (VCAM-1) levels were significantly higher in arsenic-endemic subjects than those in nonendemic subjects. All these circulating molecules showed significant correlations with arsenic exposure (water, hair, and nail arsenic concentrations), and all these relations were significant before and after adjusting for relevant covariates. Among the circulating molecules tested in this study, HDL, Ox-LDL, and CRP showed dose-response relationships with arsenic exposure. Ox-LDL/ HDL ratios were increased with the increasing concentrations of arsenic in the water, hair, and nails. Furthermore, non-HDL cholesterol and TC/ HDL ratios were significantly correlated with arsenic exposure before and after adjusting for relevant covariates. Thus, all the observed associations may be the major features of arsenic exposure-related atherosclerosis leading to CVD.

Place, publisher, year, edition, pages
Oxford University Press, 2013. Vol. 135, no 1, 17-25 p.
Keyword [en]
Arsenic, Atherosclerosis, Bangladesh, High-density lipoprotein, Oxidized low-density lipoprotein
National Category
Natural Sciences
Research subject
Natural sciences
Identifiers
URN: urn:nbn:se:his:diva-8577DOI: 10.1093/toxsci/kft130ISI: 000323624500002PubMedID: 23761297Scopus ID: 2-s2.0-84883149574OAI: oai:DiVA.org:his-8577DiVA: diva2:659881
Available from: 2013-10-28 Created: 2013-10-28 Last updated: 2013-11-13Bibliographically approved

Open Access in DiVA

No full text

Other links

Publisher's full textPubMedScopushttp://toxsci.oxfordjournals.org/content/135/1/17.long

Search in DiVA

By author/editor
Mandal, Abul
By organisation
School of Life SciencesThe Systems Biology Research Centre
In the same journal
Toxicological Sciences
Natural Sciences

Search outside of DiVA

GoogleGoogle Scholar

Altmetric score

Total: 795 hits
CiteExportLink to record
Permanent link

Direct link
Cite
Citation style
  • apa
  • ieee
  • modern-language-association-8th-edition
  • vancouver
  • Other style
More styles
Language
  • de-DE
  • en-GB
  • en-US
  • fi-FI
  • nn-NO
  • nn-NB
  • sv-SE
  • Other locale
More languages
Output format
  • html
  • text
  • asciidoc
  • rtf