Many healthcare organizations are currently committed to organizational change and quality improvement projects. Unfortunately, little effort is put into health information system development according to usability requirements and methodology, leading to bottlenecks in the eHealth systems when implemented into daily practice. This paper presents a national initiative to build usability of eHealth systems into the Swedish national eHealth strategy and its action plan to ensure impact on practice. Action researchers within the health informatics domain collaborated with representatives of different care professions to propose high-priority changes necessary to improve the usability of health information systems.