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Toward Quantifying the Thymic Dysfunctional State in Mouse Models of Inflammatory Bowel Disease
University of Skövde, School of Life Sciences. University of Skövde, The Systems Biology Research Centre.
University of Skövde, School of Life Sciences. University of Skövde, The Systems Biology Research Centre.ORCID iD: 0000-0003-4221-6013
University of Skövde, School of Life Sciences. University of Skövde, The Systems Biology Research Centre.
Fraunhofer-Chalmers Research Centre for Industrial Mathematics, Gothenburg, Sweden.
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2013 (English)In: Inflammatory Bowel Diseases, ISSN 1078-0998, E-ISSN 1536-4844, Vol. 19, no 4, 881-888 p.Article, review/survey (Refereed) Published
Abstract [en]

Inflammatory bowel disease is characterized by a number of immunological alterations, not the least in the T-cell compartment. Numerous animal models of colitis have revealed aberrant thymocyte dynamics associated with skewed thymocyte development. The recent advancements in quantitative methods have proposed critical kinetic alterations in the thymocyte development during the progression of colitis. This review focuses on the aberrant thymocyte dynamics in G alpha i2-deficient mice as this mouse model provides most quantitative data of the thymocyte development associated with colitis. Herein, we discuss several dynamic changes during the progression of colitis and propose a hypothesis for the underlying causes for the skewed proportions of the thymocyte populations seen in the G alpha i2-deficient mice and in other mouse models of colitis. (Inflamm Bowel Dis 2013; 19: 881-888)

Place, publisher, year, edition, pages
Lippincott Williams & Wilkins, 2013. Vol. 19, no 4, 881-888 p.
Keyword [en]
kinetics, thymocyte, thymus, IBD, colitis
National Category
Natural Sciences
Research subject
Natural sciences
Identifiers
URN: urn:nbn:se:his:diva-8399DOI: 10.1097/MIB.0b013e3182802c58ISI: 000316451600037PubMedID: 23448795Scopus ID: 2-s2.0-84884651875OAI: oai:DiVA.org:his-8399DiVA: diva2:640418
Available from: 2013-08-13 Created: 2013-08-13 Last updated: 2014-12-19Bibliographically approved

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Jansson, AndreasPernestig, Anna-KarinNilsson, Patric

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