B2B development has been faster in the developed world comparing to developing countries. This chapter proposes a “tool” for managing CSF in B2B settings. The tool is in the form of guidelines, which are concrete and detailed, and which enable a more clear view of actions needed during the preparation stage of B2B projects. We argue that developing countries seldom have the luxury of affording failure in new B2B ventures, but that they instead must learn from the mistakes already made by the developed countries. Thus, our proposed guidelines are based on an existing framework and experiences made in the developed countries. The guidelines are furthermore discussed with regard to the specific problems and conditions that developing countries face. Much work still remains, and problems still must be resolved. From a global perspective, this is important for all of us!