Simulation and visualisation software such as digital human modelling (DHM) tools have been designed to predict and evaluate ergonomics within a virtual environment. Today’s DHM tools typically include observation-based evaluation methods, initially designed for visual observation. Direct measurement techniques enable assessment of quantitative data similar to the information derived from the DHM. Such technique allows detailed and time-dependent risk aspects to be considered in the ergonomics evaluation. No methods in commercial DHM software calculate time-dependent information, which is shown as an important risk factor in the development of work-related musculoskeletal disorder (WMSD). This paper presents and discusses an ergonomics assessment approach based on the theory of a dose-response relationship between exposure and the risk of arising injury. The focus of the approach presented is on the wrist-joint.