This paper presents a new and robust approach for the accurate evaluation of minimumzone spatial straightness error from a set of coordinate measurement data points. The algorithm iteratively searches for the specific data points that define the minimum bound of the spatial straightness zone using combinatorial optimization. It is based on the fact that the minimum circumscribed cylinder of a point set, which is equivalent to the minimum spatial straightness zone of the measurement data, will pass through three, four, or five of the data points that constitute the convex hull vertices of the entire data set. Computed results have shown that although the presented approach may lead to increased computational time, it is robust and able to construct the exact minimum circumscribed cylinder for a given point set. The minimum-zone spatial straightness error can thus be evaluated with the best possible accuracy. The advantage of the presented algorithm is demonstrated via comparison with published computed results of existing algorithms.