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NF-kappa B p65 phosphorylated at serine-536 is an independent prognostic factor in Swedish colorectal cancer patients
Division of Oncology, Department of Clinical and Experimental Medicine, Faculty of Health Sciences, Linköping University, SE-581 85, Linköping, Sweden.
Division of Oncology, Department of Clinical and Experimental Medicine, Faculty of Health Sciences, Linköping University, SE-581 85, Linköping, Sweden.
Department of Health and Society, Faculty of Health Sciences, Linköping University, SE-581 85 Linköping, Sweden.
Department of Surgery, Country Council of Östergötland, Norrköping, Sweden.
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2012 (English)In: International Journal of Colorectal Disease, ISSN 0179-1958, E-ISSN 1432-1262, Vol. 27, no 4, 447-452 p.Article in journal (Refereed) Published
Abstract [en]

The NF-kappa B transcription factor protein family has diverse cellular and biological functions, and posttranslational modification is important to regulate these functions. An important site of phosphorylation of NF-kappa B p65 subunit is at serine-536 (phospho-Ser536-p65), and this phosphorylation is involved in regulation of transcriptional activity, nuclear localization, and protein stability. In this study, we investigated expression of phospho-Ser536-p65 in colorectal cancers and its relationships with clinicopathological factors. The expression of phospho-Ser536-p65 was examined by immunohistochemistry in 203 primary colorectal cancers, 156 normal mucosa specimens, and 18 metastases in the lymph nodes. The expression of phospho-Ser536-p65 increased from normal mucosa to primary tumor (p < 0.0001). Further, the increased expression of phospho-Ser536-p65 in the cytoplasm of the primary tumors correlated with worse survival of the patients independently of gender, age, tumor location, stage, and differentiation (p = 0.04; hazard ratio, 1.89; 95% CI 1.03-3.47). The NF-kappa B p65 subunit phosphorylated at serine-536 is an independent prognostic factor in colorectal cancer patients.

Place, publisher, year, edition, pages
Springer, 2012. Vol. 27, no 4, 447-452 p.
Keyword [en]
NF-kappa B, Survival, Colorectal cancer, Immunohistochemistry
National Category
Natural Sciences
Research subject
Natural sciences
Identifiers
URN: urn:nbn:se:his:diva-5692DOI: 10.1007/s00384-011-1356-8ISI: 000301777100004PubMedID: 22102084Scopus ID: 2-s2.0-84862986139OAI: oai:DiVA.org:his-5692DiVA: diva2:515462
Available from: 2012-04-13 Created: 2012-04-13 Last updated: 2013-10-14Bibliographically approved

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Publisher's full textPubMedScopushttp://link.springer.com/article/10.1007%2Fs00384-011-1356-8

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CiteExportLink to record
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