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Expression of NF-kappa B p65 phosphorylated at serine-536 in rectal cancer with or without preoperative radiotherapy
Department of Oncology, Institute of Clinical and Experimental Medicine, University of Linköping, SE-581 85 Linköping, Sweden.
Department of Oncology, Institute of Clinical and Experimental Medicine, University of Linköping, SE-581 85 Linköping, Sweden.
Department of Oncology, Karolinska University Hospital, Stockholm, Sweden.
University of Skövde, School of Life Sciences. University of Skövde, The Systems Biology Research Centre.
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2011 (English)In: Radiology and Oncology, ISSN 1318-2099, Vol. 45, no 4, 279-284 p.Article in journal (Refereed) Published
Abstract [en]

Background. In the present study, we investigated NF-kappa B p65 phosphorylated at Serine-536 (phosphor-Ser536-p65) in rectal cancer and its relationship to preoperative radiotherapy (RT), clinicopathological variables and biological factors. Patients and methods. Expression of phosphor-Ser536-p65 was examined by using immunohistochemistry in 141 primary rectal cancers, 149 normal mucosa specimens and 48 metastases in the lymph nodes, from rectal cancer patients who participated in a Swedish clinical trial of preoperative RT. Results. The expression of phosphor-Ser536-p65 in the cytoplasm increased from normal mucosa to primary tumour (p<0.0001, for both the group that did and the group that did not received RT). The expression did not further increase from primary tumour to metastasis in either group (p>0.05). Expression of phosphor-Ser536-p65 was positively related to, or tended to be related to, the expression of tumour endothelium marker 1 (TEM1, p=0.02), FXYD-3 (p=0.001), phosphatase of regenerating liver (PRL, p=0.02), p73 (p=0.048) and meningioma associated protein (MAC30, p=0.05) in the group that received RT but there were no such relationships in the group that did not received RT (p>0.05). The expression of phosphor-Ser536-p65 was not related to clinicopathological factors including survival (p>0.05). Conclusions. The increased expression of phosphor-Ser536-p65 may be involved in rectal cancer development. After RT, phosphor-Ser536-p65 seems to be positively related to the biological factors, which associated with more malignant features of tumours. However, phosphor-Ser536-p65 was not directly related to the response of RT based on recurrence and survival.

Place, publisher, year, edition, pages
Walter de Gruyter, 2011. Vol. 45, no 4, 279-284 p.
Keyword [en]
NF-kappa B, serine-536, radiotherapy, rectal cancer, immunohistochemistry, recurrence, prognosis
National Category
Cancer and Oncology
Research subject
Medical sciences
Identifiers
URN: urn:nbn:se:his:diva-5510DOI: 10.2478/v10019-011-0030-7ISI: 000297064900006PubMedID: 22933966Scopus ID: 2-s2.0-81755171096OAI: oai:DiVA.org:his-5510DiVA: diva2:512929
Available from: 2012-03-29 Created: 2012-03-01 Last updated: 2013-04-11Bibliographically approved

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