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Kinetic proofreading and the search for nonself-peptides
University of Skövde, School of Life Sciences. University of Skövde, The Systems Biology Research Centre.
2011 (English)In: Self/Nonself, ISSN 1938-2049, Vol. 2, no 1, 1-3 p.Article in journal (Refereed) Published
Abstract [en]

The T cells scan the surface of antigen-presenting cells with their T cell receptors (TCR) in order to find and respond to specific peptide-major histocompatibility complexes (pMHC). Since mainly self-peptides are expressed on antigen-presenting cells, the T cells must utilize sensible mechanisms in order to quickly discriminate between self and nonself-peptides. A range of different models have been proposed to account for this process. Due to the experimental inconsistency of how T cells respond to altered peptides it has been difficult to validate the competing models. Recent models, based on the kinetic proofreading model, propose that a short life-time of the TCR/pMHC complexes may be compensated by fast rebinding of the individual molecules. Hence, both the on- and off-rate involved in the interaction between pMHCs and TCRs will determine the fate of the T cell discrimination. I here briefly review some of the proposed models on T cell discrimination and scanning, and discuss the significance of determining self-peptide kinetics to validate the different models.

Place, publisher, year, edition, pages
Landes Bioscience , 2011. Vol. 2, no 1, 1-3 p.
Keyword [en]
mathematical, model, scanning, antigen, TCR, discrimination
National Category
Natural Sciences
Research subject
Natural sciences
Identifiers
URN: urn:nbn:se:his:diva-5631DOI: 10.4161/self.2.1.15362Scopus ID: 2-s2.0-79960351356OAI: oai:DiVA.org:his-5631DiVA: diva2:512050
Available from: 2012-03-26 Created: 2012-03-26 Last updated: 2016-12-29Bibliographically approved

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Citation style
  • apa
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  • de-DE
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  • nn-NB
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