his.sePublications
Change search
CiteExportLink to record
Permanent link

Direct link
Cite
Citation style
  • apa
  • harvard1
  • ieee
  • modern-language-association-8th-edition
  • vancouver
  • Other style
More styles
Language
  • de-DE
  • en-GB
  • en-US
  • fi-FI
  • nn-NO
  • nn-NB
  • sv-SE
  • Other locale
More languages
Output format
  • html
  • text
  • asciidoc
  • rtf
Dose-response relationship between arsenic exposure and the serum enzymes for liver function tests in the individuals exposed to arsenic: a cross sectional study in Bangladesh
Rajshahi Univ, Dept Biochem & Mol Biol, Rajshahi 6205, Bangladesh .
Rajshahi Univ, Dept Biochem & Mol Biol, Rajshahi 6205, Bangladesh .
Rajshahi Univ, Dept Biochem & Mol Biol, Rajshahi 6205, Bangladesh / Islamic Univ, Dept Appl Nutr & Food Technol, Kushtia 7003, Bangladesh / UMP, FIST, Gambang 26300, Pahang, Malaysia .
Rajshahi Univ, Dept Biochem & Mol Biol, Rajshahi 6205, Bangladesh .
Show others and affiliations
2011 (English)In: Environmental health, ISSN 1476-069X, Vol. 10, 64- p.Article in journal (Refereed) Published
Abstract [en]

Background: Chronic arsenic exposure has been shown to cause liver damage. However, serum hepatic enzyme activity as recognized on liver function tests (LFTs) showing a dose-response relationship with arsenic exposure has not yet been clearly documented. The aim of our study was to investigate the dose-response relationship between arsenic exposure and major serum enzyme marker activity associated with LFTs in the population living in arsenic-endemic areas in Bangladesh. Methods: A total of 200 residents living in arsenic-endemic areas in Bangladesh were selected as study subjects. Arsenic concentrations in the drinking water, hair and nails were measured by Inductively Coupled Plasma Mass Spectroscopy (ICP-MS). The study subjects were stratified into quartile groups as follows, based on concentrations of arsenic in the drinking water, as well as in subjects' hair and nails: lowest, low, medium and high. The serum hepatic enzyme activities of alkaline phosphatase (ALP), aspartate transaminase (AST) and alanine transaminase (ALT) were then assayed. Results: Arsenic concentrations in the subjects' hair and nails were positively correlated with arsenic levels in the drinking water. As regards the exposure-response relationship with arsenic in the drinking water, the respective activities of ALP, AST and ALT were found to be significantly increased in the high-exposure groups compared to the lowest-exposure groups before and after adjustments were made for different covariates. With internal exposure markers (arsenic in hair and nails), the ALP, AST and ALT activity profiles assumed a similar shape of dose-response relationship, with very few differences seen in the higher groups compared to the lowest group, most likely due to the temporalities of exposure metrics. Conclusions: The present study demonstrated that arsenic concentrations in the drinking water were strongly correlated with arsenic concentrations in the subjects' hair and nails. Further, this study revealed a novel exposure- and dose- response relationship between arsenic exposure metrics and serum hepatic enzyme activity. Elevated serum hepatic enzyme activities in the higher exposure gradients provided new insights into arsenic-induced liver toxicity that might be helpful for the early prognosis of arsenic-induced liver diseases.

Place, publisher, year, edition, pages
BioMed Central, 2011. Vol. 10, 64- p.
National Category
Environmental Sciences
Research subject
Natural sciences
Identifiers
URN: urn:nbn:se:his:diva-5533DOI: 10.1186/1476-069X-10-64ISI: 000293342700001Scopus ID: 2-s2.0-79959974151OAI: oai:DiVA.org:his-5533DiVA: diva2:510951
Available from: 2012-03-19 Created: 2012-03-01 Last updated: 2012-12-10Bibliographically approved

Open Access in DiVA

No full text

Other links

Publisher's full textScopus

Search in DiVA

By author/editor
Mandal, Abul
By organisation
School of Life SciencesThe Systems Biology Research Centre
In the same journal
Environmental health
Environmental Sciences

Search outside of DiVA

GoogleGoogle Scholar

Altmetric score

Total: 771 hits
CiteExportLink to record
Permanent link

Direct link
Cite
Citation style
  • apa
  • harvard1
  • ieee
  • modern-language-association-8th-edition
  • vancouver
  • Other style
More styles
Language
  • de-DE
  • en-GB
  • en-US
  • fi-FI
  • nn-NO
  • nn-NB
  • sv-SE
  • Other locale
More languages
Output format
  • html
  • text
  • asciidoc
  • rtf