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A miRNA expression signature that separates between normal and malignant prostate tissues
University of Skövde, School of Life Sciences. University of Skövde, The Systems Biology Research Centre.
Orebro Univ Hosp, Dept Urol, Orebro, Sweden / Univ Orebro, Sch Hlth & Med Sci, Orebro, Sweden.
Orebro Univ Hosp, Dept Lab Med, Orebro, Sweden.
Orebro Univ Hosp, Dept Lab Med, Orebro, Sweden.
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2011 (English)In: Cancer Cell International, ISSN 1475-2867, Vol. 11, 14- p.Article in journal (Refereed) Published
Abstract [en]

Background: MicroRNAs (miRNAs) constitute a class of small non-coding RNAs that post-transcriptionally regulate genes involved in several key biological processes and thus are involved in various diseases, including cancer. In this study we aimed to identify a miRNA expression signature that could be used to separate between normal and malignant prostate tissues. Results: Nine miRNAs were found to be differentially expressed (p < 0.00001). With the exception of two samples, this expression signature could be used to separate between the normal and malignant tissues. A cross-validation procedure confirmed the generality of this expression signature. We also identified 16 miRNAs that possibly could be used as a complement to current methods for grading of prostate tumor tissues. Conclusions: We found an expression signature based on nine differentially expressed miRNAs that with high accuracy (85%) could classify the normal and malignant prostate tissues in patients from the Swedish Watchful Waiting cohort. The results show that there are significant differences in miRNA expression between normal and malignant prostate tissue, indicating that these small RNA molecules might be important in the biogenesis of prostate cancer and potentially useful for clinical diagnosis of the disease.

Place, publisher, year, edition, pages
BioMed Central, 2011. Vol. 11, 14- p.
National Category
Cancer and Oncology
Research subject
Medical sciences
Identifiers
URN: urn:nbn:se:his:diva-5544DOI: 10.1186/1475-2867-11-14ISI: 000292110200001Scopus ID: 2-s2.0-79957484812OAI: oai:DiVA.org:his-5544DiVA: diva2:508734
Available from: 2012-03-09 Created: 2012-03-01 Last updated: 2013-04-10Bibliographically approved

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Carlsson, JessicaLubovac, ZelminaOlsson, BjörnKlinga-Levan, Karin
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