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CRF and urotensin I effects on aggression and anxiety-like behavior in rainbow trout
Uppsala Univ, Dept Neurosci, Physiol Unit, Biomed Ctr BMC, SE-75123 Uppsala, Sweden / Uppsala Univ, Evolutionary Biol Ctr, SE-75236 Uppsala, Sweden .
Swedish Univ Agr Sci, Dept Food Sci, SE-75007 Uppsala, Sweden.
University of Skövde, School of Life Sciences.
Uppsala Univ, Dept Neurosci, Physiol Unit, Biomed Ctr BMC, SE-75123 Uppsala, Sweden .
2011 (English)In: Journal of Experimental Biology, ISSN 0022-0949, Vol. 214, no 6, 907-914 p.Article in journal (Refereed) Published
Abstract [en]

Corticotropin-releasing factor (CRF) is central in the stress response but also modulates several behaviors including anxiety-related behaviors and aggression. In this study, juvenile rainbow trout (Oncorhynchus mykiss) were tested for competitive ability, determined during dyadic fights for dominance, after intracerebroventricular (i.c.v.) administration of CRF, urotensin I (UI), the non-specific CRF antagonist alpha-helical RF(9-41) (ahCRF) or the CRF receptor subtype 1-specific antagonist antalarmin, when paired with a mass-matched con-specific injected with saline. In addition, isolated fish received the same substances. Plasma cortisol and brain monoamines were monitored in all fish. Most fish receiving CRF showed a conspicuous behavior consisting of flaring the opercula, opening the mouth and violent shaking of the head from side to side. When this occurred, the fish immediately forfeited the fight. Similar behavior was observed in most fish receiving UI but no effect on outcome of dyadic fights was noted. This behavior seems similar to non-ambulatory motor activity seen in rats and could be anxiety related. Furthermore, fish receiving CRF at a dose of 1000. ng became subordinate, whereas all other treatments had no effects on the outcome of dyadic fights. In addition, isolated fish receiving ahCRF had lower brain stem concentrations of 5-hydroxyindoleacetic acid, serotonin, 3,4-dihydroxyphenylacetic acid and dopamine. In conclusion, CRF seems to attenuate competitive ability, and both CRF and UI seem to induce anxiety-like behavior.

Place, publisher, year, edition, pages
The company of biologists , 2011. Vol. 214, no 6, 907-914 p.
Keyword [en]
aggression, anxiety, corticotropin releasing factor, cortisol, dopamine, dyadic fight, monoamine, urotensin I, UI, serotonin, stress
National Category
Biological Sciences
Research subject
Natural sciences
Identifiers
URN: urn:nbn:se:his:diva-5559DOI: 10.1242/jeb.045070ISI: 000287649500011Scopus ID: 2-s2.0-79951980988OAI: oai:DiVA.org:his-5559DiVA: diva2:508142
Available from: 2012-03-07 Created: 2012-03-01 Last updated: 2013-04-09Bibliographically approved

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Citation style
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