his.sePublications
Change search
CiteExportLink to record
Permanent link

Direct link
Cite
Citation style
  • apa
  • harvard1
  • ieee
  • modern-language-association-8th-edition
  • vancouver
  • Other style
More styles
Language
  • de-DE
  • en-GB
  • en-US
  • fi-FI
  • nn-NO
  • nn-NB
  • sv-SE
  • Other locale
More languages
Output format
  • html
  • text
  • asciidoc
  • rtf
Is selective primary visual cortex stimulation achievable with TMS?
Univ Turku, Ctr Cognit Neurosci, FIN-20014 Turku, Finland / Univ Turku, Dept Psychol, FIN-20014 Turku, Finland .
Univ Turku, Ctr Cognit Neurosci, FIN-20014 Turku, Finland / Univ Turku, Dept Psychol, FIN-20014 Turku, Finland .
University of Skövde, School of Humanities and Informatics.ORCID iD: 0000-0002-2771-1588
Univ Turku, Ctr Cognit Neurosci, FIN-20014 Turku, Finland / Univ Turku, Dept Psychol, FIN-20014 Turku, Finland .
Show others and affiliations
2012 (English)In: Human Brain Mapping, ISSN 1065-9471, E-ISSN 1097-0193, Vol. 33, no 3, 652-665 p.Article in journal (Refereed) Published
Abstract [en]

The primary visual cortex (V1) has been the target of stimulation in a number of transcranial magnetic stimulation (TMS) studies. In this study, we estimated the actual sites of stimulation by modeling the cortical location of the TMS-induced electric field when participants reported visual phosphenes or scotomas. First, individual retinotopic areas were identified by multifocal functional magnetic resonance imaging (mffMRI). Second, during the TMS stimulation, the cortical stimulation sites were derived from electric field modeling. When an external anatomical landmark for V1 was used (2 cm above inion), the cortical stimulation landed in various functional areas in different individuals, the dorsal V2 being the most affected area at the group level. When V1 was specifically targeted based on the individual mffMRI data, V1 could be selectively stimulated in half of the participants. In the rest, the selective stimulation of V1 was obstructed by the intermediate position of the dorsal V2. We conclude that the selective stimulation of V1 is possible only if V1 happens to be favorably located in the individual anatomy. Selective and successful targeting of TMS pulses to V1 requires MRI-navigated stimulation, selection of participants and coil positions based on detailed retinotopic maps of individual functional anatomy, and computational modeling of the TMS-induced electric field distribution in the visual cortex. It remains to be resolved whether even more selective stimulation of V1 could be achieved by adjusting the coil orientation according to sulcal orientation of the target site. Hum Brain Mapp, 2012. (C) 2011 Wiley Periodicals, Inc.

Place, publisher, year, edition, pages
Wiley-Blackwell, 2012. Vol. 33, no 3, 652-665 p.
Keyword [en]
transcranial magnetic stimulation (TMS), functional magnetic resonance imaging (fMRI), V1, V2, visual cortex, retinotopic mapping, phosphenes, visual suppression, visual perception
National Category
Natural Sciences
Research subject
Natural sciences
Identifiers
URN: urn:nbn:se:his:diva-5485DOI: 10.1002/hbm.21237ISI: 000300004100013PubMedID: 21416561Scopus ID: 2-s2.0-84856732624OAI: oai:DiVA.org:his-5485DiVA: diva2:506928
Available from: 2012-03-01 Created: 2012-03-01 Last updated: 2016-04-28Bibliographically approved

Open Access in DiVA

No full text

Other links

Publisher's full textPubMedScopusExtern länk till fulltext

Search in DiVA

By author/editor
Revonsuo, Antti
By organisation
School of Humanities and Informatics
In the same journal
Human Brain Mapping
Natural Sciences

Search outside of DiVA

GoogleGoogle Scholar

Altmetric score

Total: 770 hits
CiteExportLink to record
Permanent link

Direct link
Cite
Citation style
  • apa
  • harvard1
  • ieee
  • modern-language-association-8th-edition
  • vancouver
  • Other style
More styles
Language
  • de-DE
  • en-GB
  • en-US
  • fi-FI
  • nn-NO
  • nn-NB
  • sv-SE
  • Other locale
More languages
Output format
  • html
  • text
  • asciidoc
  • rtf