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Intestinal metabolite compound K of panaxoside inhibits the growth of gastric carcinoma by augmenting apoptosis via Bid-mediated mitochondrial pathway
Xiamen Univ, Coll Med, Canc Res Ctr, Xiamen 361005, Peoples R China .
Xiamen Univ, Coll Med, Canc Res Ctr, Xiamen 361005, Peoples R China .
Xiamen Univ, Coll Med, Dept Basic Med, Xiamen 361005, Peoples R China.
Xiamen Univ, Coll Med, Zhongshan Affiliated Hosp, Xiamen 361005, Peoples R China .
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2012 (English)In: Journal of Cellular and Molecular Medicine (Print), ISSN 1582-1838, Vol. 16, no 1, 96-106 p.Article in journal (Refereed) Published
Abstract [en]

Compound K (20-O-beta-D-glucopyranosyl-20(S)-protopanaxadiol, CK), an intestinal bacterial metabolite of panaxoside, has been shown to inhibit tumour growth in a variety of tumours. However, the mechanisms involved are largely unknown. We use human gastric carcinoma cell lines BGC823, SGC7901 and human gastric carcinoma xenograft in nude mice as models to study the mechanisms of CK in gastric cancers. We found that CK significantly inhibits the viabilities of BGC823 and SGC7901 cells in dose- and time-dependent manners. CK-induced BGC823 and SGC7901 cells apoptosis and cell cycle arrest in G2 phase by up-regulation of p21 and down-regulation of cdc2 and cyclin B1. Further studies show that CK induces apoptosis in BGC823 and SGC7901 cells mainly through mitochondria-mediated internal pathway, and that CK induces the translocation of nuclear Bid to mitochondria. Finally, we found that CK effectively inhibited the tumour formation of SGC7901 cells in nude mice. Our studies show that CK can inhibit the viabilities and induce apoptosis of human gastric carcinoma cells via Bid-mediated mitochondrial pathway.

Place, publisher, year, edition, pages
2012. Vol. 16, no 1, 96-106 p.
Keyword [en]
gastric carcinoma, compound K, Bid, apoptosis
National Category
Natural Sciences
Research subject
Natural sciences
Identifiers
URN: urn:nbn:se:his:diva-5459DOI: 10.1111/j.1582-4934.2011.01278.xISI: 000298586600009PubMedID: 21323864Scopus ID: 2-s2.0-84855174764OAI: oai:DiVA.org:his-5459DiVA: diva2:504872
Available from: 2012-02-22 Created: 2012-02-22 Last updated: 2013-10-14Bibliographically approved

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CiteExportLink to record
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