his.sePublications
Change search
CiteExportLink to record
Permanent link

Direct link
Cite
Citation style
  • apa
  • harvard1
  • ieee
  • modern-language-association-8th-edition
  • vancouver
  • Other style
More styles
Language
  • de-DE
  • en-GB
  • en-US
  • fi-FI
  • nn-NO
  • nn-NB
  • sv-SE
  • Other locale
More languages
Output format
  • html
  • text
  • asciidoc
  • rtf
RNA interference and its therapeutic potential
University of Copenhagen.
Flinders University.
University of Skövde, The Systems Biology Research Centre. University of Skövde, School of Life Sciences.
2011 (English)In: Central European Journal of Medicine, ISSN 1895-1058, Vol. 6, no 2, 137-147 p.Article, review/survey (Refereed) Published
Abstract [en]

RNA interference is a technique that has become popular in the past few years. This is a biological method to detect the activity of a specific gene within a cell. RNAi is the introduction of homologous double stranded RNA to specifically target a gene’s product resulting in null or hypomorphic phenotypes. This technique involves the degradation of specific mRNA by using small interfering RNA. Both microRNA (miRNA) and small interfering RNA (siRNA) are directly related to RNA interference. RNAi mechanism is being explored as a new technique for suppressing gene expression. It is an important issue in the treatment of various diseases. This review considers different aspects of RNAi technique including its history of discovery, molecular mechanism, gene expression study, advantages of this technique against previously used techniques, barrier associated with this technique, and its therapeutic application.

Place, publisher, year, edition, pages
Versita , 2011. Vol. 6, no 2, 137-147 p.
Keyword [en]
Cancer, MircoRNA, Interfering RNA, Disease
National Category
Natural Sciences
Research subject
Natural sciences
Identifiers
URN: urn:nbn:se:his:diva-5195DOI: 10.2478/s11536-011-0005-5ISI: 000287452100001Scopus ID: 2-s2.0-79956374124OAI: oai:DiVA.org:his-5195DiVA: diva2:429223
Available from: 2011-07-04 Created: 2011-07-04 Last updated: 2013-04-15Bibliographically approved

Open Access in DiVA

No full text

Other links

Publisher's full textScopus

Search in DiVA

By author/editor
Mandal, Abul
By organisation
The Systems Biology Research CentreSchool of Life Sciences
In the same journal
Central European Journal of Medicine
Natural Sciences

Search outside of DiVA

GoogleGoogle Scholar

Altmetric score

Total: 734 hits
CiteExportLink to record
Permanent link

Direct link
Cite
Citation style
  • apa
  • harvard1
  • ieee
  • modern-language-association-8th-edition
  • vancouver
  • Other style
More styles
Language
  • de-DE
  • en-GB
  • en-US
  • fi-FI
  • nn-NO
  • nn-NB
  • sv-SE
  • Other locale
More languages
Output format
  • html
  • text
  • asciidoc
  • rtf