his.sePublications
Change search
CiteExportLink to record
Permanent link

Direct link
Cite
Citation style
  • apa
  • harvard1
  • ieee
  • modern-language-association-8th-edition
  • vancouver
  • Other style
More styles
Language
  • de-DE
  • en-GB
  • en-US
  • fi-FI
  • nn-NO
  • nn-NB
  • sv-SE
  • Other locale
More languages
Output format
  • html
  • text
  • asciidoc
  • rtf
High-resolution genomic profiling to predict 10-year overall survival in node-negative breast cancer
University of Gothenburg.
University of Gothenburg.
University of Gothenburg.
University of Gothenburg.
Show others and affiliations
2010 (English)In: Cancer Genetics and Cytogenetics, ISSN 0165-4608, E-ISSN 1873-4456, Vol. 198, no 2, 79-89 p.Article in journal (Refereed) Published
Abstract [en]

Women with clinically node-negative breast cancer have a better prognosis than do those with axillary lymph node metastasis. Nonetheless, ~20% of node-negative patients die within 15 years of diagnosis, and thus additional prognostic markers are greatly needed. To identify specific copy number alterations (CNAs) that differed in frequency between 10-year survivors and deceased patients with node-negative breast cancer, array comparative genomic hybridization (aCGH) was applied to 41 primary node-negative breast tumors. Fisher's exact test was used to identify significantly different CNAs between 10-year survivors and deceased patients. Losses at 8p21.2~p21.3, 8p23.1~p23.2, Xp21.3, and Xp22.31~p22.33 were significantly more common in tumors from deceased patients, suggesting that these alterations may contribute to tumor aggressiveness. Gains at 1q25.2~q25.3 and 1q31.3~q41 were more prevalent in tumors from survivors; specific gains at these genomic regions may inhibit further tumor progression, resulting in a less aggressive form of node-negative breast cancer. Evaluation of the identified CNAs in an independent external data set verified the prognistic potential of the 1q31.3~q41 region. Although further extensive validation is needed, the prognostic CNAs identified in this work may in time facilitate the clinical assessment of breast cancer.

Place, publisher, year, edition, pages
Elsevier, 2010. Vol. 198, no 2, 79-89 p.
National Category
Natural Sciences
Research subject
Natural sciences
Identifiers
URN: urn:nbn:se:his:diva-4497DOI: 10.1016/j.cancergencyto.2009.12.012ISI: 000276781000001PubMedID: 20362222Scopus ID: 2-s2.0-77950856355OAI: oai:DiVA.org:his-4497DiVA: diva2:381395
Available from: 2010-12-27 Created: 2010-12-27 Last updated: 2013-04-09Bibliographically approved

Open Access in DiVA

No full text

Other links

Publisher's full textPubMedScopus

Search in DiVA

By author/editor
Olsson, Björn
By organisation
The Systems Biology Research CentreSchool of Life Sciences
In the same journal
Cancer Genetics and Cytogenetics
Natural Sciences

Search outside of DiVA

GoogleGoogle Scholar

Altmetric score

Total: 743 hits
CiteExportLink to record
Permanent link

Direct link
Cite
Citation style
  • apa
  • harvard1
  • ieee
  • modern-language-association-8th-edition
  • vancouver
  • Other style
More styles
Language
  • de-DE
  • en-GB
  • en-US
  • fi-FI
  • nn-NO
  • nn-NB
  • sv-SE
  • Other locale
More languages
Output format
  • html
  • text
  • asciidoc
  • rtf