his.sePublications
Change search
CiteExportLink to record
Permanent link

Direct link
Cite
Citation style
  • apa
  • harvard1
  • ieee
  • modern-language-association-8th-edition
  • vancouver
  • Other style
More styles
Language
  • de-DE
  • en-GB
  • en-US
  • fi-FI
  • nn-NO
  • nn-NB
  • sv-SE
  • Other locale
More languages
Output format
  • html
  • text
  • asciidoc
  • rtf
Evolutionary search for improved path diagrams
University of Skövde, School of Humanities and Informatics.
University of Skövde, School of Humanities and Informatics.
Show others and affiliations
2007 (English)In: Evolutionary Computation, Machine Learning and Data Mining in Bioinformatics: 5th European Conference. LNCS 4447, Springer Berlin/Heidelberg, 2007, 114-121 p.Conference paper, (Refereed)
Abstract [en]

A path diagram relates observed, pairwise, variable correlations to a functional structure which describes the hypothesized causal relations between the variables. Here we combine path diagrams, heuristics and evolutionary search into a system which seeks to improve existing gene regulatory models. Our evaluation shows that once a correct model has been identified it receives a lower prediction error compared to incorrect models, indicating the overall feasibility of this approach. However, with smaller samples the observed correlations gradually become more misleading, and the evolutionary search increasingly converges on suboptimal models. Future work will incorporate publicly available sources of experimentally verified biological facts to computationally suggest model modifications which might improve the model’s fitness.

Place, publisher, year, edition, pages
Springer Berlin/Heidelberg, 2007. 114-121 p.
Series
Lecture Notes in Computer Science (including subseries Lecture Notes in Artificial Intelligence and Lecture Notes in Bioinformatics), ISSN 0302-9743, 1611-3349 ; 4447 LNCS
Identifiers
URN: urn:nbn:se:his:diva-2124DOI: 10.1007/978-3-540-71783-6_11ISI: 000246102100011Scopus ID: 2-s2.0-38049047606ISBN: 978-3-540-71782-9 OAI: oai:DiVA.org:his-2124DiVA: diva2:32400
Available from: 2008-06-03 Created: 2008-06-03 Last updated: 2013-03-18

Open Access in DiVA

No full text

Other links

Publisher's full textScopushttp://www.springerlink.com/content/a1806821081p2867/fulltext.pdf

Search in DiVA

By author/editor
Laurio, KimNilsson, PatricGamalielsson, JonasOlsson, Björn
By organisation
School of Humanities and Informatics

Search outside of DiVA

GoogleGoogle Scholar

Altmetric score

Total: 751 hits
CiteExportLink to record
Permanent link

Direct link
Cite
Citation style
  • apa
  • harvard1
  • ieee
  • modern-language-association-8th-edition
  • vancouver
  • Other style
More styles
Language
  • de-DE
  • en-GB
  • en-US
  • fi-FI
  • nn-NO
  • nn-NB
  • sv-SE
  • Other locale
More languages
Output format
  • html
  • text
  • asciidoc
  • rtf